Re: [GIWorld-Hepatitis] Garlic
- There is a study on this but it doesnt implicate garlic in any potential effect on treatment.
In the study one garlic capsule was administered twice a day and very careful pharmacokinetics studies were performed. The results were dramatic: garlic reduces the levels of saquinavir by 50%. No data was presented about other antiretrovirals, but this study questions the use of these supplements concomitantly with protease inhibitors. The therapeutic implications of this are unknown.
Saquinavir is used almost exclusively in combination with ritonavir, but no data was presented about the three-way interaction. It might be that ritonavir "compensates" for the effects of garlic.
It is possible that these interactions will occur when you take an overdose of "pills" with such supplements. Natural garlic when taken in food should not cause any problem.
Dr Sharat Misra MD,DM,FACG
Although I am a strong proponent of complimentary
medicines, I do have to say that I just read an
article where it was shown that consumption of garlic
decreased the levels in the body of some of the anti
virals used in the treatment of HIV, and they were
saying it might be a concern, since garlic is used by
some HIV patients to control cholesterol, which tends
to rise when one has AIDS. It didn't say efficacy was
reduced, but levels were lowered which may result in
diminished effectiveness. So even garlic may have
some circumstances where it isn't harmless.
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