>>No wonder my cholesterol is only 152. We put garlicin just about everything. It also lowers blood
pressure for those of you with that problem. OF
course none of this is proven, but my blood pressure
went down and the stress level certainly didn't, if
anything it got worse with David's diagnosis.
Arch Latinoam Nutr 2000 Sep;50(3):219-29 Related
[Review: cardiovascular effect of garlic (Allium
[Article in Spanish]
Garcia Gomez LJ, Sanchez-Muniz FJ.
Departamento de Nutricion y Bromatologia I
(Nutricion), Facultad de Farmacia, Universidad
Complutense de Madrid, Madrid-Espana.
Garlic has been used for centuries, and even nowadays
is part of popular medicine in many cultures. New data
have increased the interest in garlic and its role in
normalization and treatment of cardiovascular disease
risk factors. Recent studies have shown the complex
composition of garlic, containing many compounds, that
present potential positive effect in the field of
health. The aim of the present paper was to review
results of some studies that have found a relationship
between garlic and cardiovascular diseases. From some
of them it can be summarized that garlic can normalize
plasma lipid, check lipid peroxidation, stimulate
fibrinolytic activity, inhibit platelet aggregation,
smooth the thickening and structural changes of artery
wall related to aging and atherosclerosis, and
decrease blood pressure. However, some other studies
do not support these benefits. The positive effects
found have promoted many study projects, nevertheless,
the extract lability and the lack of result consensus
call for a moderate consumption of garlic and garlic
extracts. The composition variation due to gathering
and aging together with the changes occurring in
canning and industrial treatment makes necessary the
application of some norms in the production and
consumption of this functional food in order to
guarantee its use in adequate form and doses.
PMID: 11347290 [PubMed - indexed for MEDLINE]
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- There is a study on this but it doesnt implicate garlic in any potential effect on treatment.
In the study one garlic capsule was administered twice a day and very careful pharmacokinetics studies were performed. The results were dramatic: garlic reduces the levels of saquinavir by 50%. No data was presented about other antiretrovirals, but this study questions the use of these supplements concomitantly with protease inhibitors. The therapeutic implications of this are unknown.
Saquinavir is used almost exclusively in combination with ritonavir, but no data was presented about the three-way interaction. It might be that ritonavir "compensates" for the effects of garlic.
It is possible that these interactions will occur when you take an overdose of "pills" with such supplements. Natural garlic when taken in food should not cause any problem.
Dr Sharat Misra MD,DM,FACG
Although I am a strong proponent of complimentary
medicines, I do have to say that I just read an
article where it was shown that consumption of garlic
decreased the levels in the body of some of the anti
virals used in the treatment of HIV, and they were
saying it might be a concern, since garlic is used by
some HIV patients to control cholesterol, which tends
to rise when one has AIDS. It didn't say efficacy was
reduced, but levels were lowered which may result in
diminished effectiveness. So even garlic may have
some circumstances where it isn't harmless.
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