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Does HIV Infection Favor the Sexual Transmission of Hepatitis C?

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  • claudine intexas
    NATAP - www.natap.org ... Does HIV Infection Favor the Sexual Transmission of Hepatitis C? Editorial note from Jules Levin: For a while I have been trying to
    Message 1 of 1 , Dec 30, 2001
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      NATAP - www.natap.org
      ---------------------------------

      Does HIV Infection Favor the Sexual Transmission of
      Hepatitis C?

      Editorial note from Jules Levin: For a while I have
      been trying to draw attention to the underappreciated
      risk of sexual transmission of HCV in other than
      monogamous HIV-, STD-negative relationships. Without
      knowing further details of this study it adds to a
      growing body of evidence suggesting there is a risk of
      HCV sexual transmission under certain circumstances:
      when HIV, STDs & risky sexual behavior which may draw
      blood unknowingly.

      Filippini P, Coppola N, Scolastico C, Rossi G, Onofrio
      M, Sagnelli E, Piccinino F.

      Institute of Infectious Diseases, Second University of
      Naples, Naples, Italy.

      BACKGROUND: There are widely discrepant findings on
      the sexual transmission of hepatitis C virus (HCV),
      commonly transmitted by the parenteral route.
      Coinfection with HCV is common in subjects infected
      with HIV.

      GOAL: This case-control study evaluated the prevalence
      of anti-HCV in subjects with hetero- or homosexual
      contact and no history of intravenous drug abuse or
      blood transfusion, according to the presence or
      absence of HIV infection.

      STUDY DESIGN: In this case-control study, the cases
      considered were 106 consecutive patients who showed
      positive anti-HIV test results. For each case, two
      control subjects were selected who had been screened
      for HIV infection at the authors' center and found to
      have anti-HIV-negative test results, and who matched
      the case in terms age (+/- 5 years), gender, and risk
      factor for parenterally transmitted infections.

      RESULTS: The prevalence of subjects with positive test
      results for hepatitis B surface antigen(HBsAg) was
      similar between cases and control subjects (4.7%
      versus 2.4%). Positivity for anti-hepatitis B core
      antigen in connection with negative test results for
      HBsAg was observed more frequently in the 106 cases
      than in the 212 control subjects (33.9% versus 15.6%;
      P =0.0003). Anti-HCV positivity was more frequent in
      the cases than in the control subjects (15.1% versus
      5.2%; P = 0.005). In particular, among subjects who
      had hetero- or homosexual intercourse with a steady
      partner who had positive anti-HIV test results,
      anti-HCV positivity was observed in 18.7% of the 32
      cases and 1.6% of the 64 control subjects (P = 0.008).


      CONCLUSION: This study demonstrated that in subjects
      who had only a sexual risk factor for parenterally
      transmitted infections, HIV may enhance the sexual
      transmission of HCV.



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