Extrahepatic manifestations of infection with hepatitis C virus. 11/2001
- Clin Liver Dis 2001 Nov;5(4):979-1008
Extrahepatic manifestations of infection with
hepatitis C virus.
Mehta S, Levey JM, Bonkovsky HL.
Division of Digestive Disease and Nutrition,
University of Massachusetts Medical School, UMass
Memorial Health Care, Worcester, Massachusetts, USA.
Chronic hepatitis C is associated with, and may
trigger or exacerbate, an extraordinary variety of
extrahepatic manifestations. Most of these
manifestations affect the skin, the most frequent and
important of which are the leukocytoclastic vasculitis
of MC type II and PCT. The former is an example of an
autoimmune disorder triggered by HCV infection,
whereas PCT is a skin disease caused by hepatic
overproduction of uro- and 7-carboxyl porphyrins
caused by increased oxidative stress in hepatocytes.
Currently available effective therapies of CHC (IFN,
ribavirin) may also trigger or exacerbate extrahepatic
manifestations, especially including autoimmune
thyroiditis, skin rashes, and hemolytic anemia.
PMID: 11685805 [PubMed - in process]
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