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Extrahepatic manifestations of infection with hepatitis C virus. 11/2001

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  • claudine intexas
    Clin Liver Dis 2001 Nov;5(4):979-1008 Extrahepatic manifestations of infection with hepatitis C virus. Mehta S, Levey JM, Bonkovsky HL. Division of Digestive
    Message 1 of 1 , Nov 27, 2001
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      Clin Liver Dis 2001 Nov;5(4):979-1008

      Extrahepatic manifestations of infection with
      hepatitis C virus.

      Mehta S, Levey JM, Bonkovsky HL.

      Division of Digestive Disease and Nutrition,
      University of Massachusetts Medical School, UMass
      Memorial Health Care, Worcester, Massachusetts, USA.
      MehtaS@...

      Chronic hepatitis C is associated with, and may
      trigger or exacerbate, an extraordinary variety of
      extrahepatic manifestations. Most of these
      manifestations affect the skin, the most frequent and
      important of which are the leukocytoclastic vasculitis
      of MC type II and PCT. The former is an example of an
      autoimmune disorder triggered by HCV infection,
      whereas PCT is a skin disease caused by hepatic
      overproduction of uro- and 7-carboxyl porphyrins
      caused by increased oxidative stress in hepatocytes.
      Currently available effective therapies of CHC (IFN,
      ribavirin) may also trigger or exacerbate extrahepatic
      manifestations, especially including autoimmune
      thyroiditis, skin rashes, and hemolytic anemia.

      PMID: 11685805 [PubMed - in process]

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