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Hepatitis C outbreak among gynecology patients

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  • claudine intexas
    J. Clin. Microbiol. 2001; 39: 2860-3 31 July 2001 Hepatitis C outbreak among gynecology patients Italian doctors have investigated an outbreak of hepatitis C
    Message 1 of 1 , Aug 3, 2001
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      J. Clin. Microbiol. 2001; 39: 2860-3
      31 July 2001

      Hepatitis C outbreak among gynecology patients

      Italian doctors have investigated an outbreak of
      hepatitis C infection among gynecological patients
      undergoing surgery at the same clinic.


      Dr Marco Massari and colleagues used molecular
      fingerprinting analysis and epidemiological techniques
      to examine 4 recent cases of hepatitis C infection in
      patients at the same gynecology clinic.

      Dr Massari identified the possible source of the
      infection as an HCV-positive woman, who was the first
      patient of a surgical session that also included the
      four other women involved in the outbreak.

      All 5 patients were infected with hepatitis C virus
      type 1b.

      Molecular characterization of HCV isolates in each
      patient revealed a close homology between the viral
      isolates of the suggested source of the infection and
      those from the outbreak patients.

      Molecular characterization was achieved by sequence
      analysis of structural envelope regions and the
      nonstructural NS5 region of the viral genome.

      Dr Massari's team also compared the viral isolates of
      the source with those from 4 unrelated cases of
      hepatitis C type 1b in the same area (controls).


      Transmission was by administration of propofol from
      multi-dose vials
      Journal of Clinical Microbiology

      The controls were significantly less similar to the
      viral isolates of the source patient then isolates
      from the outbreak patients.

      The investigation of the outbreak revealed that the
      virus was transmitted by administration of propofol
      from multi-dose vials.

      Dr Massari concludes, "The study documents the risk of
      nosocomial transmission of HCV and the importance of
      infection control procedures in the operating room."

      This research also highlights the role of molecular
      strategies in the investigation of HCV outbreaks.










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