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10-Year Follow-up After Interferon- Therapy for Chronic Hepatitis C

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  • claudine intexas
    10-Year Follow-up After Interferon- Therapy for Chronic Hepatitis C: all 5 patients with sustained viral response remained HCV-RNA negative by liver biopsy. It
    Message 1 of 3 , Aug 3, 2001
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      10-Year Follow-up After Interferon- Therapy for
      Chronic Hepatitis C:
      all 5 patients with sustained viral response remained
      HCV-RNA negative
      by
      liver biopsy. It remains to be seen if this can occur
      in coinfection.



      Sustained responses to interferon- occur in 10% to 25%
      of patients with
      chronic hepatitis C, but the long-term outcome is not
      well defined. We
      evaluated the long-term clinical, histological, and
      virological
      outcomes of
      10 patients with chronic hepatitis C who were treated
      between 1984 and
      1987
      with interferon--2b for 52 �� 6 weeks (total doses of
      492 �� 116 MU).
      Before
      therapy, all 10 had hepatitis C virus (HCV) RNA,
      elevations of serum
      aminotransferases, and chronic hepatitis with fibrosis
      on liver biopsy.
      Clinical follow up was 6 to 13 years, and liver
      biopsies were done 5 to
      11
      years after initiation of therapy. HCV RNA was assayed
      by qualitative
      and
      quantitative reverse transcriptase���polymerase chain
      reaction assays.
      Among 5
      patients who had a 6-month sustained response after
      therapy, all
      remained HCV
      RNA negative, and at last follow-up, 4 had normal and
      1 minimally
      elevated
      serum aminotransferase levels. Liver biopsy specimens
      were nonreactive
      for
      HCV RNA, and all the patients showed improvements in
      both inflammation
      and
      fibrosis and were either normal or had mild,
      nonspecific inflammatory
      changes. Among 5 patients without a sustained
      response, all continued
      to have
      HCV RNA in serum and persistent or intermittent
      aminotransferase
      elevations.
      Liver biopsy specimens showed little or no change in
      necrosis and
      inflammation; all except 1 patient had progression of
      fibrosis scores
      or
      cirrhosis. All 5 patients had symptoms of chronic
      hepatitis, 1
      underwent
      liver transplantation, and another had progressive
      hepatic
      decompensation. In
      conclusion, patients with a 6-month posttreatment
      virological response
      have a
      favorable long-term clinical and histological outcome.


      (Hepatology 1998;28:1121-1127.) authors: Hoofnagle,
      Lau, et al

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    • AndromedaGurl
      co infection wtih what? are they saying the fibrosis is a co infection? alley
      Message 2 of 3 , Aug 5, 2001
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        co infection wtih what? are they saying the fibrosis is a co infection?

        alley
      • claudine intexas
        ... I d have to go back and re-read it, but I think they were talking about co-infection with HIV. __________________________________________________ Do You
        Message 3 of 3 , Aug 5, 2001
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          --- AndromedaGurl <andromedagurl@...> wrote:
          > co infection wtih what? are they saying the fibrosis
          > is a co infection?
          >
          > alley
          I'd have to go back and re-read it, but I think they
          were talking about co-infection with HIV.

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