Loading ...
Sorry, an error occurred while loading the content.
 

Effects of alcohol consumption on histological changes in chronic

Expand Messages
  • claudine intexas
    Alcohol Clin Exp Res 2000 Apr;24(4 Suppl):106S-111S Effects of alcohol consumption on histological changes in chronic hepatitis C: a clinicopathological study.
    Message 1 of 1 , Jun 25, 2001
      Alcohol Clin Exp Res 2000 Apr;24(4 Suppl):106S-111S

      Effects of alcohol consumption on histological changes
      in chronic
      hepatitis
      C: a clinicopathological study.

      Tamai T, Seki T, Shiro T, Nakagawa T, Wakabayashi M,
      Imamura M,
      Nishimura A,
      Yamashiki N, Takasu M, Inoue K, Okamura A

      Third Department of Internal Medicine, Kansai Medical
      University,
      Moriguchi,
      Osaka, Japan.

      BACKGROUND: To assess the effects of alcohol on the
      histological
      changes in
      chronic hepatitis type C, we performed
      histopathological examination on
      liver biopsy specimens by using a semiquantitative
      method. METHODS:
      Subjects
      were 91 patients with chronic hepatitis type C and 32
      with alcoholic
      liver
      disease. The patients with chronic hepatitis type C
      were classified
      into
      three groups according to the total amount of alcohol
      intake:
      nondrinkers,
      moderate drinkers, and heavy drinkers. For each
      patient, we evaluated
      pathological changes of several items and awarded
      scores from 0 to 2
      points,
      with severe to moderate scoring 2 points, mild 1, and
      negative 0; the
      total
      score was then compared between groups. The evaluated
      histological
      changes
      included virus-related histological changes (V1,
      inflammatory cell
      infiltration; V2, lymphoid follicle formation; and V3,
      bile duct
      damage) and
      alcohol-related changes (A1, perivenular fibrosis; A2,

      stellate/pericellular
      fibrosis; and A3, fatty change). RESULTS: The total
      scores of the
      hepatitis
      C virus-related histological changes were
      significantly lower in
      patients
      with alcoholic liver disease (ALD group) (p < 0.05).
      However, we found
      no
      significant difference between the different alcohol
      intake groups. The
      total score for alcohol-related histological changes
      significantly
      increased
      in line with increases in total alcoholic intake
      regardless of the
      presence
      or absence of hepatitis type C virus infection (p <
      0.05). CONCLUSIONS:
      The
      results suggest that both alcoholic-related liver
      damage and
      virus-related
      liver damage have specific features; in a addition,
      alcohol was found
      to
      have little effect on the histological liver damage
      observed in chronic
      hepatitis type C.

      PMID: 10803791, UI: 20260936


      __________________________________________________
      Do You Yahoo!?
      Get personalized email addresses from Yahoo! Mail
      http://personal.mail.yahoo.com/
    Your message has been successfully submitted and would be delivered to recipients shortly.