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Osteodystrophy in patients with chronic hepatitis and liver cirrhosis.

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  • claudine intexas
    J Gastroenterol 1996 Oct;31(5):669-78 Osteodystrophy in patients with chronic hepatitis and liver cirrhosis. Tsuneoka K, Tameda Y, Takase K, Nakano T First
    Message 1 of 1 , Jun 5, 2001
      J Gastroenterol 1996 Oct;31(5):669-78

      Osteodystrophy in patients with chronic hepatitis and
      liver cirrhosis.

      Tsuneoka K, Tameda Y, Takase K, Nakano T

      First Department of Internal Medicine, Mie University
      School of
      Medicine,
      Japan.

      Bone mineral density (BMD) of the lumber vertebrae and
      factors related
      to
      bone metabolism were determined in patients with
      chronic viral
      hepatitis and
      patients with liver cirrhosis to clarify correlations
      between hepatic
      dysfunction, considered to be one of the causes of
      hepatic
      osteodystrophy,
      and decrease in bone mass. BMD of the second to fourth
      lumbar vertebrae
      was
      determined with a Lunar (Madison, WI, USA) DPX, a
      dual-energy X-ray
      absorptiometry diagnostic system. BMD was
      significantly lowest in
      patients
      with liver cirrhosis, followed by patients with
      chronic hepatitis, and
      healthy subjects, in this order. There was a
      significantly positive but
      weak
      correlation between albumin and BMD. Levels of 25(OH)D
      and 1,25(OH)2D
      were significantly lower in patients with liver
      cirrhosis than in those
      with
      chronic hepatitis. BMD and vitamin D were decreased in
      all patients
      whose
      cholinesterase (ChE) was below 0.3 delta pH. Urinary
      pyridinoline
      (Upyr) was
      significantly higher in the patients with liver
      cirrhosis, in whom bone
      mass
      was decreased, than in the patients with chronic
      hepatitis, whereas
      serum
      osteocalcin levels were distributed in the upper
      normal range in
      patients
      with chronic hepatitis and those with liver cirrhosis.
      There was a
      positive
      correlation between 25(OH)D and serum
      osteocalcin levels in
      patients
      with liver cirrhosis. These results indicate that
      osteogenesis is
      decreased
      and suggest that the decrease in BMD which occurs in
      viral liver
      cirrhosis,
      probably related to decreased, bone formation and
      slight promotion of
      bone
      resorption, reflects deranged hepatic function. This
      is the first
      report of
      Upyr and urinary deoxypyridinoline (UDpyr)
      determination in patients
      with
      liver cirrhosis and patients with chronic hepatitis.
      The negative
      correlation of Upyr and UDpyr with ChE is a novel
      finding.

      PMID: 8887033, UI: 97041762

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