Virologic Response To Pegasys With Genotype 4 in Small Study Group
- Virologic Response To Pegasys With Genotype 4 in Small
Morris Sherman from Toronto General Hospital reported
at I think AASLD
November 2000 response to Pegasys and regular
Interferon a-2a for
with chronic HCV and genotype 4.
It has been reported that treatment with standard IFN
is less effective
patients with genotypes 1 and 4 than in patients with
genotypes 2 and
purpose of this retrospective analysis was to compare
Pegasys (40 kDa) IFN a-2a once weekly with IFN a-2a
taken 3 times
patients chronically infected with hepatitis C with
the difficult to
genotype 4. The investigators looked at a database
consisting of 1208
patients from large randomized phase II and III
studies comparing three
weekly injections of IFN a-2a (3 MIU or 6 MIU) to
treatment with once
Pegasys IFN a-2a (180 ug). Effectiveness was evaluated
in a subset of
patients infected with genotype 4.
Sixteen patients were found to have genotype 4. Five
treatment with IFN a-2a three times weekly and 11 were
treated with 180
Pegasys IFN a-2a once weekly for up to 48 weeks.
male (63%), with baseline viral loads ranging from
8,000 to >12 million
copies/ml (COBAS Amplicor Monitor HCV, version 2.0).
cirrhosis. End-of-treatment (week 48) virologic
Test version 2.0 with lower limit of detection of 100
the standard IFN a-2a patients and 73% in the Pegasys
virologic response (week 72) was obtained on 0% of
standard IFN and 45% in Pegasys treated patients. All
sustained virologic responders were also sustained
Paired biopsies (pre and post treatment) were obtained
for 8 patients
with Pegasys and histologic response (improved liver
measured by a
>2 point decrease in Histology Activity Index (HAI)was found in 5 of
patients (63%). Histologic response was observed in
2/3 patiented with
biopsies and treated with standard IFN.
The authors concluded that the number of patients with
genotype 4 found
respond well to Pegasys was small, but the data are
that further larger studies should be conducted in
genotype 4 patients.
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