Transient transmission of hepatitis C virus from mothers to newborns.
- Eur J Clin Microbiol Infect Dis 2000 Apr;19(4):267-74
Transient transmission of hepatitis C virus from
mothers to newborns.
Ketzinel-Gilad M, Colodner SL, Hadary R, Granot E,
Shouval D, Galun E
Liver Unit, Hadassah University Hospital, Ein Kerem,
[Medline record in process]
A study was performed in Israel to determine the rate
HCV transmission in newborns at risk. A group of 22
their 23 newborns were followed up from early after
birth by testing
serum for the presence of HCV antibodies and HCV-RNA.
was detected in the blood of all newborns immediately
after birth, but
dropped to low or undetectable levels by 7 months of
age. HCV-RNA was
detected 2 days after birth in the blood of five
infants (22%) but fell
undetectable levels by 6 months. HCV-HVR1 sequence
mother-infant pair on the second day after birth
changes. Two months later the same sequence was
detected again in the
suggesting a very low replication rate. Thus, the
study showed that
vertically transmitted HCV was eliminated in all
newborn infants by 6
after delivery, with concomitant disappearance of HCV
mechanism of HCV elimination in newborns at risk
remains to be
PMID: 10834815, UI: 20292667
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