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Transient transmission of hepatitis C virus from mothers to newborns.

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    Eur J Clin Microbiol Infect Dis 2000 Apr;19(4):267-74 Transient transmission of hepatitis C virus from mothers to newborns. Ketzinel-Gilad M, Colodner SL,
    Message 1 of 1 , Jan 1, 2001
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      Eur J Clin Microbiol Infect Dis 2000 Apr;19(4):267-74

      Transient transmission of hepatitis C virus from
      mothers to newborns.

      Ketzinel-Gilad M, Colodner SL, Hadary R, Granot E,
      Shouval D, Galun E

      Liver Unit, Hadassah University Hospital, Ein Kerem,
      Jerusalem, Israel.

      [Medline record in process]

      A study was performed in Israel to determine the rate
      of
      mother-to-infant
      HCV transmission in newborns at risk. A group of 22
      HCV-infected
      mothers and
      their 23 newborns were followed up from early after
      birth by testing
      their
      serum for the presence of HCV antibodies and HCV-RNA.
      Antibody against
      HCV
      was detected in the blood of all newborns immediately
      after birth, but
      dropped to low or undetectable levels by 7 months of
      age. HCV-RNA was
      detected 2 days after birth in the blood of five
      infants (22%) but fell
      to
      undetectable levels by 6 months. HCV-HVR1 sequence
      analysis performed
      in one
      mother-infant pair on the second day after birth
      revealed two
      nucleotide
      changes. Two months later the same sequence was
      detected again in the
      HVR1,
      suggesting a very low replication rate. Thus, the
      study showed that
      vertically transmitted HCV was eliminated in all
      newborn infants by 6
      months
      after delivery, with concomitant disappearance of HCV
      antibodies. The
      mechanism of HCV elimination in newborns at risk
      remains to be
      elucidated.

      PMID: 10834815, UI: 20292667


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