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The Association between Infection with Hepatitis C Virus and Diabetes

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  • claudine intexas
    The full report is titled Prevalence of Type 2 Diabetes Mellitus among Persons with Hepatitis C Virus Infection in the United States. It is in the 17 October
    Message 1 of 1 , Dec 28, 2000
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      The full report is titled "Prevalence of Type 2
      Diabetes Mellitus among Persons with Hepatitis C Virus
      Infection in the United States." It is in the 17
      October 2000 issue of Annals of Internal Medicine
      (volume 133, pages 592-599). The authors are SH Mehta,
      FL Brancati, MS Sulkowski, SA Strathdee, M Szklo, and
      DL Thomas. |Full Text|


      The Association between Infection with Hepatitis C
      Virus and Diabetes

      What is the problem and what is known about it so far?

      Infection with hepatitis C virus (HCV) can lead to
      liver problems. Chronic HCV infection has also been
      associated with illnesses not related to the liver.
      For example, some small studies suggest that diabetes
      is more common in people with HCV infection than in
      persons without it. Diabetes affects the body's
      ability to produce or respond to insulin, a hormone
      that regulates how the body uses carbohydrate,
      protein, and fat. There are two types of diabetes.
      Type 1 diabetes begins during childhood or young
      adulthood. People with type 1 diabetes do not make
      enough insulin. Type 2 diabetes, also known as
      adult-onset diabetes, interferes with the body's
      ability to respond to insulin. Over time, high blood
      sugar levels in both type 1 and type 2 diabetes can
      lead to such complications as blindness, kidney
      failure, and heart disease.

      Why did the researchers do this particular study?

      To see whether the likelihood of developing diabetes
      is increased among persons with HCV infection in the
      general adult population in the United States.

      Who was studied?

      Nearly 10,000 persons older than 20 years of age who
      participated in the Third National Health and
      Nutrition Examination Survey (NHANES III) during 1988
      to 1994 and had complete evaluation for HCV infection
      and for diabetes.

      How was the study done?

      NHANES III was conducted by interviewing a sample of
      the U.S. civilian population in their own homes. The
      survey asked about personal characteristics, medical
      history, current and past medicine use, and health
      behaviors. Ninety-one percent of participants also had
      a physical examination and blood tests. The blood
      tests included measurement of the blood sugar level
      (to detect diabetes) and a test for HCV infection,
      which was done by the U.S. Centers for Disease Control
      and Prevention. The researchers compared the frequency
      of diabetes (type 1 and type 2) in persons with and
      those without HCV infection.

      What did the researchers find?

      Of the 9841 persons studied, 1242 had type 2 diabetes
      and 230 had HCV infection. People with HCV infection
      were more than three times more likely than people
      without HCV infection to have type 2 diabetes. None of
      the 19 persons with type 1 diabetes had HCV infection.

      What were the limitations of the study?

      This study suggests an association between type 2
      diabetes and HCV infection, but it does not prove that
      the infection causes diabetes.

      What are the implications of the study?

      In the United States, type 2 diabetes occurs more
      often in people with HCV infection than it does in
      people without this infection.

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