Soybean Extract Found Protective In Alcoholic Liver Disease
- Soybean Extract Found Protective In Alcoholic Liver
November 2, 2000
DALLAS (Reuters Health) - An extract from soybeans has
been found to
or perhaps even reverse, progression of liver fibrosis
in alcoholics in
randomized, double-blind, placebo controlled trial.
Eighteen alcoholic patients were randomized to receive
extract polyenylphosphatidylcholine (PPC). Five of the
nine on placebo
showed fibrotic progression on liver biopsies 2 years
later. For the
PPC, liver histology was unchanged or slightly
improved, reported Dr.
Charles S. Lieber, of the VA Medical Center and Mount
Sinai School of
Medicine, Bronx, New York.
Dr. Lieber described his group's study at the annual
meeting of the
Association for the Study of Liver Diseases.
All of the patients enrolled had livers that showed
complete cirrhosis. Both groups continued to drink
heavily, yet their
compliance with the protocol was high: patients showed
up for more than
of their office visits, and they took their pill every
day more than
the time, Dr. Lieber said.
There is a need for an effective therapy in these
current prognosis is dismal. "In patients with
alcoholic cirrhosis who
over 60 years old, there is a 50% mortality at 1
year," Dr. Lieber
"Much of this toxicity is because alcohol is
The extract PPC is a 95% pure mixture of
phosphatidylcholines, about half of which is
(DLPC). Dr. Lieber's earlier work in nonhuman primates
opposes oxidative stress, one of several mechanisms
alcohol's hepatotoxicity. Patients who were taking PPC
levels of DLPC than controls, further suggesting that
DLPC may be the
active, antioxidant ingredient, he said.
The study of PPC to prevent alcoholic liver fibrosis
has been expanded
involve 17 VA Medical Centers nationwide, Dr. Lieber
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