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Soybean Extract Found Protective In Alcoholic Liver Disease

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  • claudine intexas
    Soybean Extract Found Protective In Alcoholic Liver Disease November 2, 2000 DALLAS (Reuters Health) - An extract from soybeans has been found to halt, or
    Message 1 of 1 , Nov 4, 2000
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      Soybean Extract Found Protective In Alcoholic Liver
      Disease


      November 2, 2000
      DALLAS (Reuters Health) - An extract from soybeans has
      been found to
      halt,
      or perhaps even reverse, progression of liver fibrosis
      in alcoholics in
      a
      randomized, double-blind, placebo controlled trial.
      Eighteen alcoholic patients were randomized to receive
      either placebo
      or the
      extract polyenylphosphatidylcholine (PPC). Five of the
      nine on placebo
      showed fibrotic progression on liver biopsies 2 years
      later. For the
      nine on
      PPC, liver histology was unchanged or slightly
      improved, reported Dr.
      Charles S. Lieber, of the VA Medical Center and Mount
      Sinai School of
      Medicine, Bronx, New York.
      Dr. Lieber described his group's study at the annual
      meeting of the
      American
      Association for the Study of Liver Diseases.
      All of the patients enrolled had livers that showed
      fibrosis without
      complete cirrhosis. Both groups continued to drink
      heavily, yet their
      compliance with the protocol was high: patients showed
      up for more than
      90%
      of their office visits, and they took their pill every
      day more than
      80% of
      the time, Dr. Lieber said.
      There is a need for an effective therapy in these
      patients because
      their
      current prognosis is dismal. "In patients with
      alcoholic cirrhosis who
      are
      over 60 years old, there is a 50% mortality at 1
      year," Dr. Lieber
      said.
      "Much of this toxicity is because alcohol is
      metabolized preferentially
      in
      the liver."
      The extract PPC is a 95% pure mixture of
      polyunsaturated
      phosphatidylcholines, about half of which is
      dilinoleoylphosphatidylcholine
      (DLPC). Dr. Lieber's earlier work in nonhuman primates
      suggested that
      DLPC
      opposes oxidative stress, one of several mechanisms
      thought responsible
      for
      alcohol's hepatotoxicity. Patients who were taking PPC
      had higher
      plasma
      levels of DLPC than controls, further suggesting that
      DLPC may be the
      active, antioxidant ingredient, he said.
      The study of PPC to prevent alcoholic liver fibrosis
      has been expanded
      to
      involve 17 VA Medical Centers nationwide, Dr. Lieber
      said.

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