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Vitamin E Normalizes Elevated Liver Enzymes in Children With Steatohepatitis

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  • claudine intexas
    Not HCV, but still interesting. Another indication that Vitamin E is good for our livers! Vitamin E Normalizes Elevated Liver Enzymes in Children With
    Message 1 of 1 , Oct 29, 2000
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      Not HCV, but still interesting. Another indication
      that Vitamin E is good for our livers!

      Vitamin E Normalizes Elevated Liver Enzymes in
      Children With Steatohepatitis
      --------------------------------------------------------------------------------

      WESTPORT, Jul 07 (Reuters Health) - When children with
      steatohepatitis are given daily oral vitamin E
      supplementation, elevated liver enzymes normalize
      within 1 to 3 months.

      Dr. Joel E. Lavine from the University of California,
      in San Diego, followed 11 children ages 8.3 to 14.2
      years who were diagnosed with steatohepatitis and
      whose aminotransferase levels were elevated. On
      ultrasound, the children's livers were diffusely
      echogenic. All children presented with a body mass
      index above the 95th percentile for their age and sex;
      no other cause of liver diseases was found.

      Before treatment, "serum alanine aminotransferase and
      aspartate aminotransferase were approximately 3.9
      times and 2.3 times the upper limit of normal,
      respectively," Dr. Lavine and his colleagues note.

      According to results published in the June issue of
      The Journal of Pediatrics, five children achieved
      normal enzyme levels at the dosage of 400 IU/day. Four
      required 800 IU/day, and two required 1200 IU/day. Two
      children who discontinued vitamin E treatment
      experienced re-elevation of aminotransferase levels
      within the next 2 months.

      Ultrasound appearance of the liver remained unchanged
      even after liver enzymes were normalized. Dr. Lavine
      writes, "One can speculate that steatosis persists but
      inflammation may resolve."

      He recommends that "obese children with nonalcoholic
      steatohepatitis should be encouraged to lose weight as
      part of a comprehensive weight reduction program and
      to consider taking supplemental alpha-tocopherol."

      J Pediatr 2000;136:734-738


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