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Low Morbidity Observed in Large Experience With Living Liver Donors

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  • claudine intexas
    Low Morbidity Observed in Large Experience With Living Liver Donors ... WESTPORT (Reuters Health) Oct 23 - A large single-center Japanese report on living
    Message 1 of 1 , Oct 29, 2000
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      Low Morbidity Observed in Large Experience With Living
      Liver Donors
      --------------------------------------------------------------------------------

      WESTPORT (Reuters Health) Oct 23 - A large
      single-center Japanese report on living liver donors
      confirms that morbidity after the donor surgery is
      low, even when right lobes are taken.

      In the September issue of Transplant International,
      Dr. Koichi Tanaka and colleagues, from Kyoto
      University Hospital in Japan, analyze morbidity in 470
      consecutive living liver donors. The most common
      operation was left lateral segmentectomy, performed in
      282 of the donors.

      Extended left lateral segmentectomy without the middle
      hepatic vein was done in 45 cases, left lobectomy with
      the middle hepatic vein was done in 99, and right
      lobectomy without the middle hepatic vein was done in
      43.

      "Biliary leakage was the most common and annoying
      complication after donor operations, especially
      in...right lobe grafting, but all donors recovered
      completely with conservative or minimal invasive
      therapy," the authors report. Blood loss was lowest
      after left lateral segmentectomy, but there was no
      significant difference in blood loss between donors of
      left and right lobes.

      The researchers note that "postoperative hospital
      stays [were] comparable among all groups except for
      the [right lobe donors]." Right lobe donors also had
      higher peak aspartate aminotransferase levels and
      higher levels of this enzyme on postoperative day 7,
      but values returned to normal within 1 month in most
      donors.

      There were no deaths related to the donor operation.
      Years after their surgeries, two donors did require
      reoperation for adhesive mechanical ileus.

      According to the article, complete recoveries were
      observed even in donors with greater blood loss,
      longer-than-average hospital stays, or liver enzyme
      elevations more than 1 month after donation.

      "The morbidity of living donors is low or minimal even
      for right lobectomy, the most extended procedure," the
      investigators conclude. "Complete recovery can be
      expected in all cases."

      Transpl Int 2000;13:333-339.


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