Re: [GIWorld-Hepatitis] HCV Trivia
- I'm going to see my second MD on the 17th. I fired the first after finding
out he had serious problems communicating. I have been assembling info to
help aid in my decisions. I don't know my genotype but my pcr was 189,000
and my ALT was 62,AST 36. The rest of the workup should determine whether to
treat now or not. The whole 3x per week or daily dosing is confusing. The
rational for 3x per week seems to be to allow you to recouperate but so does
With a short life, daily or 3x per week wouldn't matter would it?
----- Original Message -----
From: "claudine intexas" <claudineintexas@...>
Sent: Saturday, August 05, 2000 12:16 AM
Subject: Re: [GIWorld-Hepatitis] HCV Trivia
> --- Paul Luketich <lukas42@...> wrote:
> > Did it mention the length of the life cycle?
> Dear Paul,
> This particular article did not mention the life
> span of the virus, but I looked through a couple of
> other articles and one of them said it had "an in vivo
> half-life of the virus in the order of a few hours",
> and another said the HCV virus had a maximum half life
> of 7 hours. It seems like I remember reading 3 - 4
> hours in some other article. Both of the articles I
> looked at just now compared HCV's short half-life and
> rapid multiplication to the HIV virus. Understanding
> how quickly this virus can recuperate and multiply,
> and how short of a time that interferon lasts in your
> system (under 24 hours) helps explain why daily dosing
> is more effective than 3 times a week.
> It is also a VERY weird feeling thinking of all
> the 'activity' going on in my liver!
> Do You Yahoo!?
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- --- Paul Luketich <lukas42@...> wrote:
> With a short life, daily or 3x per week wouldn'tDear Paul,
> matter would it?
Yes, it does matter! As for why it matters, you
really answered that yourself:
> rational for 3x per week seems to be to allow you toAnd the virus recuperates VERY fast! The
> recuperate but so does
> the virus.
interferon wears off in 24 hours or less. Within 24
more hours the virus can be right back up to
pre-injection level. However, with a second injection
24 hours after the first this can be prevented or
greatly reduced. 3 times a week dosing is ok for a
few, but for most it is not effective. As for side
effects, every person I've heard from who has done
both says that the daily is easier than 3 times a
week. You do not have the ups and downs like you do
with the 3 times a week. However, all this info
probably does you no good because it is just about
impossible to find a doctor willing to prescribe daily
dosing if that was the way you wanted to go. The
pegylated interferons are the answer to this problem,
since they will do with one injection per week what
daily dosing would have done. (You didn't expect the
drug companies to ever admit they got the "3 times a
week" dosing schedule wrong, did you? No, just come
out with a NEW drug to sell!)
Do You Yahoo!?
Kick off your party with Yahoo! Invites.