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Long-term Daily Interferon + Ribavirin

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  • claudine intexas
    J Okla State Med Assoc 1999 Dec;92(12):573-7 (ISSN: 0030-1876) Karasu Z; Gurakar A; Emmett C; Jazzar A; McMillon G; Hulagu S; Wright H [Find other articles
    Message 1 of 1 , Jul 31, 2000
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      J Okla State Med Assoc 1999 Dec;92(12):573-7 (ISSN:
      0030-1876)

      Karasu Z; Gurakar A; Emmett C; Jazzar A; McMillon G;
      Hulagu S; Wright H [Find other articles with these
      Authors]
      Nazih Zuhdi Transplantation Institute (NZTI), Oklahoma
      City, OK 73112, USA.

      The optimal dose, frequency and duration of interferon
      alpha 2b and ribavirin combination for the treatment
      of chronic hepatitis C is still not clear. Preliminary
      hepatitis C virus kinetic studies have suggested that
      daily interferon (IFN) is more advantageous than less
      frequent administration. This report documents the
      preliminary findings of an investigative protocol to
      evaluate the efficacy of long-term (12 month), daily
      IFN alpha 2b and ribavirin combination therapy for
      chronic hepatitis C patients, who have either relapsed
      (relapsers) or not responded (non-responders) to
      previous IFN therapy. METHODS: 25 non-cirrhotic HCV
      patients were enrolled in an attempt to treat
      protocol. Patients were administered 3 million units
      (MU) IFN alpha 2b subcutaneously (SQ) and ribavirin
      1000-1200 mg PO on a daily basis. RESULTS: Four
      patients were removed from the protocol because of
      noncompliance. The remaining 21 patients (10
      relapsers, 11 non-responders) were evaluated at the
      end of their 12th week of treatment. Twelve patients
      (57%) became HCV-RNA negative and nine patients (43%)
      remain positive at the end of this period. CONCLUSION:
      Although further studies on larger patient populations
      are necessary, our preliminary data suggests that
      daily IFN alpha 2b and ribavirin treatment is highly
      effective, especially among patients who have relapsed
      from previous IFN treatment.



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      Claudine
      claudinecrews@...

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