--- Alleypat <alleypat@...
> According to my doc and his crew (he has several
> P.A.'s working for him to
> give better patient to "doc" contact), when he did
> studies on daily
> injections/combo vs 3 x a week, he got no better
> response that way. just fyi
This gave me a big smile! When I brought up
daily dosing with my doctor this is the exact same
thing my doctor said to me. When I brought up all the
studies I had read that said it was better he admitted
that the reason he wouldn't prescribe daily dosing
because it is not FDA approved.
To say daily dosing is not more effective simply
doesn't make sense. One injection of regular
interferon is gone from your body in less than 24
hours. The hepatitis C virus immediately begins
multiplying as soon as that dose of interferon is
gone, and can very quickly be back at near
pre-injection level. Daily dosing keeps a supply of
interferon in your system at all times, not giving the
virus that chance to recuperate. If this were not
true, why would 2 drug manufacturers be coming out
with the pegylated interferons? They work on the same
principle - keeping a steady supply of interferon in
your body, not allowing the virus that time without
interferon to recuperate.
I have seen some studies myself that showed no
improved response with daily dosing. These studies
all had one thing in common. They did not maintain
the daily dosing, and at some point (usually at week
4) in the study switched from daily to 3 times a week
I am sending in some studies on daily dosing. A
couple of them are very interesting not only because
they are daily dosing, but because they are on
genotype 1b, the hardest genotype to get rid of, and a
couple just include relapsers and non-responders,
another difficult-to-treat group.
I would say show these studies to your doc, but I
also know sometimes this doesn't go over to well! :)
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