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Re: [GIWorld-Hepatitis] Digest Number 118

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  • Barbara Brodlieb
    ... From: To: Sent: Wednesday, April 19, 2000 12:21 AM Subject: [GIWorld-Hepatitis] Digest
    Message 1 of 1 , Jun 4, 2000
    • 0 Attachment
      ----- Original Message -----
      From: <GIWorld-Hepatitis@egroups.com>
      To: <GIWorld-Hepatitis@egroups.com>
      Sent: Wednesday, April 19, 2000 12:21 AM
      Subject: [GIWorld-Hepatitis] Digest Number 118


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      >
      > There are 25 messages in this issue.
      >
      > Topics in this digest:
      >
      > 1.
      > From: RIVERJORDAN@...
      > 2. Doc, I need your opinion, please
      > From: Constance Dickson
      <constance_clearwater_florida@...>
      > 3. continuing problrms
      > From: LEST2001@...
      > 4. Re: Doc, I need your opinion, please
      > From: "Claudine Crews" <claudinecrews@...>
      > 5. Re: Doc, I need your opinion, please
      > From: Constance Dickson
      <constance_clearwater_florida@...>
      > 6. Re: Doc, I need your opinion, please
      > From: Constance Dickson
      <constance_clearwater_florida@...>
      > 7. Re: Doc, I need your opinion, please
      > From: "Claudine Crews" <claudinecrews@...>
      > 8. Re: Doc, I need your opinion, please
      > From: Constance Dickson
      <constance_clearwater_florida@...>
      > 9. Re:
      > From: "alley/Patricia" <alleypat@...>
      > 10. Re: Doc, I need your opinion, please
      > From: "alley/Patricia" <alleypat@...>
      > 11. Re: Doc, I need your opinion, please
      > From: Constance Dickson
      <constance_clearwater_florida@...>
      > 12. Re: Doc, I need your opinion, please
      > From: Constance Dickson
      <constance_clearwater_florida@...>
      > 13. Re: Doc, I need your opinion, please
      > From: Constance Dickson
      <constance_clearwater_florida@...>
      > 14. Re: Muscle Spasms
      > From: "Doc" <gidoc@...>
      > 15. Re: Doc, I need your opinion, please
      > From: "Doc" <gidoc@...>
      > 16. Re:
      > From: "Doc" <gidoc@...>
      > 17. VIRUS ALERT/Off Topic
      > From: "Claudine Crews" <claudinecrews@...>
      > 18. 24 vs. 48 weeks controversy
      > From: srw1954@...
      > 19. Re: Doc, I need your opinion, please
      > From: Constance Dickson
      <constance_clearwater_florida@...>
      > 20. Re: Doc, I need your opinion, please
      > From: Constance Dickson
      <constance_clearwater_florida@...>
      > 21. Subject: NAOMI
      > From: "Donna Graham" <donnaliz2@...>
      > 22. Re: 24 vs. 48 weeks controversy
      > From: Constance Dickson
      <constance_clearwater_florida@...>
      > 23. Re: Doc, I need your opinion, please
      > From: "alley/Patricia" <alleypat@...>
      > 24. Re: Doc, I need your opinion, please
      > From: Constance Dickson
      <constance_clearwater_florida@...>
      > 25. Re: 3tc
      > From: "Doc" <gidoc@...>
      >
      >
      > ________________________________________________________________________
      > ________________________________________________________________________
      >
      > Message: 1
      > Date: Tue, 18 Apr 100 14:26:37 +0000
      > From: RIVERJORDAN@...
      > Subject:
      >
      > Hello,
      >
      > I see that there be lots of those that are in dicussions of hep-c and side
      > effects. Could there be anyone here with cryptogenic cirrhosis? It would
      be a
      > blessing if one would give me a response.
      >
      > Cherokee
      > Crosswaters
      >
      > _____________________________________________
      > Free email with cool domains at FriendlyEmail
      > http://www.mypad.com/
      >
      >
      >
      >
      > ________________________________________________________________________
      > ________________________________________________________________________
      >
      > Message: 2
      > Date: Tue, 18 Apr 2000 13:53:20 -0700 (PDT)
      > From: Constance Dickson <constance_clearwater_florida@...>
      > Subject: Doc, I need your opinion, please
      >
      > I saw the Dr today. The one that I did not have much
      > faith in. Well, he is pulling me off conbo or
      > anythiny else till maybe something new comes up. You
      > probably don't remember but, I am the one who lost my
      > job and insurance and had to go off meds. when I
      > first started Combo 3/99 my viral load was 12 million
      > and ALT and ASL's were high but do not remember them.
      > They had dropped in mid September to 300,000 viral
      > load and 50/60 range for liver functions. Well now my
      > viral load is 29 million he has not got the ALT or AST
      > back, but in mid Nov/99 they were up to the 120-140
      > range. He told me it would be useless to go back on
      > the combo because I am a non responder. Dr I had when
      > I had insurance and in Clearwater FL (not in this
      > armpit of FL place Inverness, FL) said he hated to
      > pull me off them because I was responding quite well
      > from the Combo,when I lost my insurance, was pulled
      > because of monitoring of my blood that was needed.
      > I do now have the biopsy report that was done
      > 3/30/99,
      > I will put down on here what it says.
      > GROSS: received are two portions of yellow gray
      > cylindrical measuring to 1.2 to 1.7 in lenght to 0.1
      > to 0.2 cm in diameter. Entirely submitted. rh/ms.
      >
      > MICRO: Examination of this hepatic tissue discloses
      > no evidence of pigment,granuloma, or metastatic tumor.
      > I do not see acidophil bodies or spotty individual
      > cell necrosis. Only an occasional focus of lobular
      > hepatitis is noted.There is quite varuable involvement
      > of portal tracts with inflammatory cells: however,
      > some of these portal tracts are very markedly widened
      > secondary to the presence of lymphocytes with an
      > occasional plasma cell. These Lymphocytes tend to
      > extend outward into the hepatic parenchyma and
      > encircle hepatic cells, forming marked uneveness of
      > the limiting plate. Examination of a Trichome
      > preparation documents the variability of portal tract
      > involement with Fibrosis; however, there is an example
      > of marked septal-to-septal fibroses without distortion
      > of surrounding architecture.
      >
      > Daignoses
      > Liver Biopsy: Chonic Hepatitis
      > Moderate periportal inflammation, grade 3.
      > Inflammation without necrosis, grade 1
      > Periportal fibrosis with portal-to-portal septa, with
      > intact architecture stage 2
      >
      > I have 2 and 1/2 months of Combo in the refridgerator
      > do you think I should stop all treatments? I have not
      > been on Combo since 10/1/99. I am going to move to GA
      > next week near Macon and try to get some kind of
      > medical help there. Please let me know what to do.
      >
      > On Genotypes what is the causing factor for certain
      > types. Also what does the dainoses of biopsy mean. I
      > don't think I should just give up. He wants to see me
      > in 6 months this new Dr. From the first I had no
      > faith in him when I had to take script back into him
      > before leaving to remind him to put Quanitive and
      > something else on it that I forget at this moment.
      > ............Connie
      > I am also Genotybe 1a.
      >
      > __________________________________________________
      > Do You Yahoo!?
      > Send online invitations with Yahoo! Invites.
      > http://invites.yahoo.com
      >
      >
      > ________________________________________________________________________
      > ________________________________________________________________________
      >
      > Message: 3
      > Date: Tue, 18 Apr 2000 18:52:13 EDT
      > From: LEST2001@...
      > Subject: continuing problrms
      >
      >
      > How does ( 9mcg) compare to IU ? Because I was taking 5 million IU
      every
      > day for 6 months then cut down to 3 million IU and came through it OK. As
      for
      > your skin use a good skin lotion like Gold-BOM
      > Take care,
      > Les
      >
      >
      >
      > ________________________________________________________________________
      > ________________________________________________________________________
      >
      > Message: 4
      > Date: Tue, 18 Apr 2000 18:32:48 CDT
      > From: "Claudine Crews" <claudinecrews@...>
      > Subject: Re: Doc, I need your opinion, please
      >
      > Hi Connie,
      > If you are moving next week I don't think I'd do anything before
      then.
      > Maybe you can find a good doctor when you get there. You would have
      needed
      > to find a new doctor anyway, wouldn't you?
      > Claudine
      >
      > PS: This is just my opinion: You were on combo for about 7 months and
      still
      > not undetectable, even though your viral load had dropped significantly.
      > Now, you viral load has jumped, just like mine did when I stopped. You are
      a
      > 1a. I think you need to find a doctor who will be willing to treat you
      > agressively, with daily dosing. (you sure don't need one that you have to
      > beg or twist his arm to get treated.) I know this is what I need, but
      > haven't found. So I am waiting for the pegylated, or a more willing
      doctor,
      > which ever comes first.
      > Claudine
      >
      > >From: Constance Dickson <constance_clearwater_florida@...>
      > >Reply-To: GIWorld-Hepatitis@egroups.com
      > >To: "'GIWorld-Hepatitis@egroups.com' Hep "
      <giworld-hepatitis@egroups.com>
      > >Subject: [GIWorld-Hepatitis] Doc, I need your opinion, please
      > >Date: Tue, 18 Apr 2000 13:53:20 -0700 (PDT)
      > >
      > >I saw the Dr today. The one that I did not have much
      > >faith in. Well, he is pulling me off conbo or
      > >anythiny else till maybe something new comes up. You
      > >probably don't remember but, I am the one who lost my
      > >job and insurance and had to go off meds. when I
      > >first started Combo 3/99 my viral load was 12 million
      > >and ALT and ASL's were high but do not remember them.
      > >They had dropped in mid September to 300,000 viral
      > >load and 50/60 range for liver functions. Well now my
      > >viral load is 29 million he has not got the ALT or AST
      > >back, but in mid Nov/99 they were up to the 120-140
      > >range. He told me it would be useless to go back on
      > >the combo because I am a non responder. Dr I had when
      > >I had insurance and in Clearwater FL (not in this
      > >armpit of FL place Inverness, FL) said he hated to
      > >pull me off them because I was responding quite well
      > >from the Combo,when I lost my insurance, was pulled
      > >because of monitoring of my blood that was needed.
      > > I do now have the biopsy report that was done
      > >3/30/99,
      > > I will put down on here what it says.
      > >GROSS: received are two portions of yellow gray
      > >cylindrical measuring to 1.2 to 1.7 in lenght to 0.1
      > >to 0.2 cm in diameter. Entirely submitted. rh/ms.
      > >
      > >MICRO: Examination of this hepatic tissue discloses
      > >no evidence of pigment,granuloma, or metastatic tumor.
      > > I do not see acidophil bodies or spotty individual
      > >cell necrosis. Only an occasional focus of lobular
      > >hepatitis is noted.There is quite varuable involvement
      > >of portal tracts with inflammatory cells: however,
      > >some of these portal tracts are very markedly widened
      > >secondary to the presence of lymphocytes with an
      > >occasional plasma cell. These Lymphocytes tend to
      > >extend outward into the hepatic parenchyma and
      > >encircle hepatic cells, forming marked uneveness of
      > >the limiting plate. Examination of a Trichome
      > >preparation documents the variability of portal tract
      > >involement with Fibrosis; however, there is an example
      > >of marked septal-to-septal fibroses without distortion
      > >of surrounding architecture.
      > >
      > >Daignoses
      > >Liver Biopsy: Chonic Hepatitis
      > >Moderate periportal inflammation, grade 3.
      > >Inflammation without necrosis, grade 1
      > >Periportal fibrosis with portal-to-portal septa, with
      > >intact architecture stage 2
      > >
      > >I have 2 and 1/2 months of Combo in the refridgerator
      > >do you think I should stop all treatments? I have not
      > >been on Combo since 10/1/99. I am going to move to GA
      > >next week near Macon and try to get some kind of
      > >medical help there. Please let me know what to do.
      > >
      > >On Genotypes what is the causing factor for certain
      > >types. Also what does the dainoses of biopsy mean. I
      > >don't think I should just give up. He wants to see me
      > >in 6 months this new Dr. From the first I had no
      > >faith in him when I had to take script back into him
      > >before leaving to remind him to put Quanitive and
      > >something else on it that I forget at this moment.
      > >............Connie
      > > I am also Genotybe 1a.
      > >
      > >__________________________________________________
      > >Do You Yahoo!?
      > >Send online invitations with Yahoo! Invites.
      > >http://invites.yahoo.com
      >
      > ______________________________________________________
      > Get Your Private, Free Email at http://www.hotmail.com
      >
      >
      >
      > ________________________________________________________________________
      > ________________________________________________________________________
      >
      > Message: 5
      > Date: Tue, 18 Apr 2000 16:41:18 -0700 (PDT)
      > From: Constance Dickson <constance_clearwater_florida@...>
      > Subject: Re: Doc, I need your opinion, please
      >
      > I don't plan on starting it right away but will have
      > to check into medicaid up there and stuff....what is
      > your viral load?
      >
      > --- Claudine Crews <claudinecrews@...> wrote:
      > > Hi Connie,
      > > If you are moving next week I don't think I'd
      > > do anything before then.
      > > Maybe you can find a good doctor when you get there.
      > > You would have needed
      > > to find a new doctor anyway, wouldn't you?
      > > Claudine
      > >
      > > PS: This is just my opinion: You were on combo for
      > > about 7 months and still
      > > not undetectable, even though your viral load had
      > > dropped significantly.
      > > Now, you viral load has jumped, just like mine did
      > > when I stopped. You are a
      > > 1a. I think you need to find a doctor who will be
      > > willing to treat you
      > > agressively, with daily dosing. (you sure don't need
      > > one that you have to
      > > beg or twist his arm to get treated.) I know this is
      > > what I need, but
      > > haven't found. So I am waiting for the pegylated,
      > > or a more willing doctor,
      > > which ever comes first.
      > > Claudine
      > >
      > > >From: Constance Dickson
      > > <constance_clearwater_florida@...>
      > > >Reply-To: GIWorld-Hepatitis@egroups.com
      > > >To: "'GIWorld-Hepatitis@egroups.com' Hep "
      > > <giworld-hepatitis@egroups.com>
      > > >Subject: [GIWorld-Hepatitis] Doc, I need your
      > > opinion, please
      > > >Date: Tue, 18 Apr 2000 13:53:20 -0700 (PDT)
      > > >
      > > >I saw the Dr today. The one that I did not have
      > > much
      > > >faith in. Well, he is pulling me off conbo or
      > > >anythiny else till maybe something new comes up.
      > > You
      > > >probably don't remember but, I am the one who lost
      > > my
      > > >job and insurance and had to go off meds. when I
      > > >first started Combo 3/99 my viral load was 12
      > > million
      > > >and ALT and ASL's were high but do not remember
      > > them.
      > > >They had dropped in mid September to 300,000 viral
      > > >load and 50/60 range for liver functions. Well now
      > > my
      > > >viral load is 29 million he has not got the ALT or
      > > AST
      > > >back, but in mid Nov/99 they were up to the 120-140
      > > >range. He told me it would be useless to go back
      > > on
      > > >the combo because I am a non responder. Dr I had
      > > when
      > > >I had insurance and in Clearwater FL (not in this
      > > >armpit of FL place Inverness, FL) said he hated to
      > > >pull me off them because I was responding quite
      > > well
      > > >from the Combo,when I lost my insurance, was pulled
      > > >because of monitoring of my blood that was needed.
      > > > I do now have the biopsy report that was done
      > > >3/30/99,
      > > > I will put down on here what it says.
      > > >GROSS: received are two portions of yellow gray
      > > >cylindrical measuring to 1.2 to 1.7 in lenght to
      > > 0.1
      > > >to 0.2 cm in diameter. Entirely submitted. rh/ms.
      > > >
      > > >MICRO: Examination of this hepatic tissue
      > > discloses
      > > >no evidence of pigment,granuloma, or metastatic
      > > tumor.
      > > > I do not see acidophil bodies or spotty
      > > individual
      > > >cell necrosis. Only an occasional focus of lobular
      > > >hepatitis is noted.There is quite varuable
      > > involvement
      > > >of portal tracts with inflammatory cells: however,
      > > >some of these portal tracts are very markedly
      > > widened
      > > >secondary to the presence of lymphocytes with an
      > > >occasional plasma cell. These Lymphocytes tend to
      > > >extend outward into the hepatic parenchyma and
      > > >encircle hepatic cells, forming marked uneveness of
      > > >the limiting plate. Examination of a Trichome
      > > >preparation documents the variability of portal
      > > tract
      > > >involement with Fibrosis; however, there is an
      > > example
      > > >of marked septal-to-septal fibroses without
      > > distortion
      > > >of surrounding architecture.
      > > >
      > > >Daignoses
      > > >Liver Biopsy: Chonic Hepatitis
      > > >Moderate periportal inflammation, grade 3.
      > > >Inflammation without necrosis, grade 1
      > > >Periportal fibrosis with portal-to-portal septa,
      > > with
      > > >intact architecture stage 2
      > > >
      > > >I have 2 and 1/2 months of Combo in the
      > > refridgerator
      > > >do you think I should stop all treatments? I have
      > > not
      > > >been on Combo since 10/1/99. I am going to move to
      > > GA
      > > >next week near Macon and try to get some kind of
      > > >medical help there. Please let me know what to do.
      > > >
      > > >On Genotypes what is the causing factor for certain
      > > >types. Also what does the dainoses of biopsy mean.
      > > I
      > > >don't think I should just give up. He wants to see
      > > me
      > > >in 6 months this new Dr. From the first I had no
      > > >faith in him when I had to take script back into
      > > him
      > > >before leaving to remind him to put Quanitive and
      > > >something else on it that I forget at this moment.
      > > >............Connie
      > > > I am also Genotybe 1a.
      > > >
      > > >__________________________________________________
      > > >Do You Yahoo!?
      > > >Send online invitations with Yahoo! Invites.
      > > >http://invites.yahoo.com
      > >
      > >
      > ______________________________________________________
      > > Get Your Private, Free Email at
      > > http://www.hotmail.com
      > >
      > >
      >
      > __________________________________________________
      > Do You Yahoo!?
      > Send online invitations with Yahoo! Invites.
      > http://invites.yahoo.com
      >
      >
      > ________________________________________________________________________
      > ________________________________________________________________________
      >
      > Message: 6
      > Date: Tue, 18 Apr 2000 16:50:35 -0700 (PDT)
      > From: Constance Dickson <constance_clearwater_florida@...>
      > Subject: Re: Doc, I need your opinion, please
      >
      > Oh and Dr said 1a and 1b are both the hardest to treat
      > but then again I don't think he knows shit. also said
      > no one should be treated for it more than 6 months I
      > was actually on Combo about 5 months
      >
      > --- Claudine Crews <claudinecrews@...> wrote:
      > > Hi Connie,
      > > If you are moving next week I don't think I'd
      > > do anything before then.
      > > Maybe you can find a good doctor when you get there.
      > > You would have needed
      > > to find a new doctor anyway, wouldn't you?
      > > Claudine
      > >
      > > PS: This is just my opinion: You were on combo for
      > > about 7 months and still
      > > not undetectable, even though your viral load had
      > > dropped significantly.
      > > Now, you viral load has jumped, just like mine did
      > > when I stopped. You are a
      > > 1a. I think you need to find a doctor who will be
      > > willing to treat you
      > > agressively, with daily dosing. (you sure don't need
      > > one that you have to
      > > beg or twist his arm to get treated.) I know this is
      > > what I need, but
      > > haven't found. So I am waiting for the pegylated,
      > > or a more willing doctor,
      > > which ever comes first.
      > > Claudine
      > >
      > > >From: Constance Dickson
      > > <constance_clearwater_florida@...>
      > > >Reply-To: GIWorld-Hepatitis@egroups.com
      > > >To: "'GIWorld-Hepatitis@egroups.com' Hep "
      > > <giworld-hepatitis@egroups.com>
      > > >Subject: [GIWorld-Hepatitis] Doc, I need your
      > > opinion, please
      > > >Date: Tue, 18 Apr 2000 13:53:20 -0700 (PDT)
      > > >
      > > >I saw the Dr today. The one that I did not have
      > > much
      > > >faith in. Well, he is pulling me off conbo or
      > > >anythiny else till maybe something new comes up.
      > > You
      > > >probably don't remember but, I am the one who lost
      > > my
      > > >job and insurance and had to go off meds. when I
      > > >first started Combo 3/99 my viral load was 12
      > > million
      > > >and ALT and ASL's were high but do not remember
      > > them.
      > > >They had dropped in mid September to 300,000 viral
      > > >load and 50/60 range for liver functions. Well now
      > > my
      > > >viral load is 29 million he has not got the ALT or
      > > AST
      > > >back, but in mid Nov/99 they were up to the 120-140
      > > >range. He told me it would be useless to go back
      > > on
      > > >the combo because I am a non responder. Dr I had
      > > when
      > > >I had insurance and in Clearwater FL (not in this
      > > >armpit of FL place Inverness, FL) said he hated to
      > > >pull me off them because I was responding quite
      > > well
      > > >from the Combo,when I lost my insurance, was pulled
      > > >because of monitoring of my blood that was needed.
      > > > I do now have the biopsy report that was done
      > > >3/30/99,
      > > > I will put down on here what it says.
      > > >GROSS: received are two portions of yellow gray
      > > >cylindrical measuring to 1.2 to 1.7 in lenght to
      > > 0.1
      > > >to 0.2 cm in diameter. Entirely submitted. rh/ms.
      > > >
      > > >MICRO: Examination of this hepatic tissue
      > > discloses
      > > >no evidence of pigment,granuloma, or metastatic
      > > tumor.
      > > > I do not see acidophil bodies or spotty
      > > individual
      > > >cell necrosis. Only an occasional focus of lobular
      > > >hepatitis is noted.There is quite varuable
      > > involvement
      > > >of portal tracts with inflammatory cells: however,
      > > >some of these portal tracts are very markedly
      > > widened
      > > >secondary to the presence of lymphocytes with an
      > > >occasional plasma cell. These Lymphocytes tend to
      > > >extend outward into the hepatic parenchyma and
      > > >encircle hepatic cells, forming marked uneveness of
      > > >the limiting plate. Examination of a Trichome
      > > >preparation documents the variability of portal
      > > tract
      > > >involement with Fibrosis; however, there is an
      > > example
      > > >of marked septal-to-septal fibroses without
      > > distortion
      > > >of surrounding architecture.
      > > >
      > > >Daignoses
      > > >Liver Biopsy: Chonic Hepatitis
      > > >Moderate periportal inflammation, grade 3.
      > > >Inflammation without necrosis, grade 1
      > > >Periportal fibrosis with portal-to-portal septa,
      > > with
      > > >intact architecture stage 2
      > > >
      > > >I have 2 and 1/2 months of Combo in the
      > > refridgerator
      > > >do you think I should stop all treatments? I have
      > > not
      > > >been on Combo since 10/1/99. I am going to move to
      > > GA
      > > >next week near Macon and try to get some kind of
      > > >medical help there. Please let me know what to do.
      > > >
      > > >On Genotypes what is the causing factor for certain
      > > >types. Also what does the dainoses of biopsy mean.
      > > I
      > > >don't think I should just give up. He wants to see
      > > me
      > > >in 6 months this new Dr. From the first I had no
      > > >faith in him when I had to take script back into
      > > him
      > > >before leaving to remind him to put Quanitive and
      > > >something else on it that I forget at this moment.
      > > >............Connie
      > > > I am also Genotybe 1a.
      > > >
      > > >__________________________________________________
      > > >Do You Yahoo!?
      > > >Send online invitations with Yahoo! Invites.
      > > >http://invites.yahoo.com
      > >
      > >
      > ______________________________________________________
      > > Get Your Private, Free Email at
      > > http://www.hotmail.com
      > >
      > >
      >
      > __________________________________________________
      > Do You Yahoo!?
      > Send online invitations with Yahoo! Invites.
      > http://invites.yahoo.com
      >
      >
      > ________________________________________________________________________
      > ________________________________________________________________________
      >
      > Message: 7
      > Date: Tue, 18 Apr 2000 19:17:11 CDT
      > From: "Claudine Crews" <claudinecrews@...>
      > Subject: Re: Doc, I need your opinion, please
      >
      > Connie, the part about the 1a and 1b is true. 1b is the hardest, 1a is
      the
      > secondd hardest. The 6mo. stuff is a bunch of bull, of course, you
      already
      > know that! Yeah, you need a new doctor!
      > Claudine
      >
      > >From: Constance Dickson <constance_clearwater_florida@...>
      > )
      > >
      > >Oh and Dr said 1a and 1b are both the hardest to treat
      > >but then again I don't think he knows shit. also said
      > >no one should be treated for it more than 6 months I
      > >was actually on Combo about 5 months
      >
      >
      > ______________________________________________________
      > Get Your Private, Free Email at http://www.hotmail.com
      >
      >
      >
      > ________________________________________________________________________
      > ________________________________________________________________________
      >
      > Message: 8
      > Date: Tue, 18 Apr 2000 17:23:24 -0700 (PDT)
      > From: Constance Dickson <constance_clearwater_florida@...>
      > Subject: Re: Doc, I need your opinion, please
      >
      > Your Viral load was a lot lower than mine I wonder why
      > mine was so high
      >
      > --- Claudine Crews <claudinecrews@...> wrote:
      > > Connie, the part about the 1a and 1b is true. 1b is
      > > the hardest, 1a is the
      > > secondd hardest. The 6mo. stuff is a bunch of bull,
      > > of course, you already
      > > know that! Yeah, you need a new doctor!
      > > Claudine
      > >
      > > >From: Constance Dickson
      > > <constance_clearwater_florida@...>
      > > )
      > > >
      > > >Oh and Dr said 1a and 1b are both the hardest to
      > > treat
      > > >but then again I don't think he knows shit. also
      > > said
      > > >no one should be treated for it more than 6 months
      > > I
      > > >was actually on Combo about 5 months
      > >
      > >
      > >
      > ______________________________________________________
      > > Get Your Private, Free Email at
      > > http://www.hotmail.com
      > >
      > >
      >
      > __________________________________________________
      > Do You Yahoo!?
      > Send online invitations with Yahoo! Invites.
      > http://invites.yahoo.com
      >
      >
      > ________________________________________________________________________
      > ________________________________________________________________________
      >
      > Message: 9
      > Date: Tue, 18 Apr 2000 18:52:34 -0500
      > From: "alley/Patricia" <alleypat@...>
      > Subject: Re:
      >
      > Hello Crosswaters, I don't know what that is myself. Could you educate us
      a
      > bit?
      > alley/Patricia
      > ICQ 12631861
      > alleypat@...
      > http://www.flash.net/~alleypat
      >
      >
      >
      > ________________________________________________________________________
      > ________________________________________________________________________
      >
      > Message: 10
      > Date: Tue, 18 Apr 2000 19:00:33 -0500
      > From: "alley/Patricia" <alleypat@...>
      > Subject: Re: Doc, I need your opinion, please
      >
      > Connie for those willing, I think treatment should be available. But
      that's
      > just my opinion. So tell us what is in Georgia for you? I hope you have
      > someone to stay with. schering can get you the treatment then you gotta
      find
      > a way to get the tests. Let us know what is happening.
      > alley/Patricia
      > ICQ 12631861
      > alleypat@...
      > http://www.flash.net/~alleypat
      >
      >
      >
      > ________________________________________________________________________
      > ________________________________________________________________________
      >
      > Message: 11
      > Date: Tue, 18 Apr 2000 18:00:52 -0700 (PDT)
      > From: Constance Dickson <constance_clearwater_florida@...>
      > Subject: Re: Doc, I need your opinion, please
      >
      > I just hope I have enough monet ...he will help but
      > will not live with him it is not something that I
      > think my daughter thinks is right...Connie
      >
      > --- alley/Patricia <alleypat@...> wrote:
      > > Connie for those willing, I think treatment should
      > > be available. But that's
      > > just my opinion. So tell us what is in Georgia for
      > > you? I hope you have
      > > someone to stay with. schering can get you the
      > > treatment then you gotta find
      > > a way to get the tests. Let us know what is
      > > happening.
      > > alley/Patricia
      > > ICQ 12631861
      > > alleypat@...
      > > http://www.flash.net/~alleypat
      > >
      > >
      >
      > __________________________________________________
      > Do You Yahoo!?
      > Send online invitations with Yahoo! Invites.
      > http://invites.yahoo.com
      >
      >
      > ________________________________________________________________________
      > ________________________________________________________________________
      >
      > Message: 12
      > Date: Tue, 18 Apr 2000 18:04:41 -0700 (PDT)
      > From: Constance Dickson <constance_clearwater_florida@...>
      > Subject: Re: Doc, I need your opinion, please
      >
      > LOL the thing I replied about why Ga it went to Eddie
      > and he asked me what was that. What I said was so I
      > could be near The one I love
      >
      > --- alley/Patricia <alleypat@...> wrote:
      > > Connie for those willing, I think treatment should
      > > be available. But that's
      > > just my opinion. So tell us what is in Georgia for
      > > you? I hope you have
      > > someone to stay with. schering can get you the
      > > treatment then you gotta find
      > > a way to get the tests. Let us know what is
      > > happening.
      > > alley/Patricia
      > > ICQ 12631861
      > > alleypat@...
      > > http://www.flash.net/~alleypat
      > >
      > >
      >
      > __________________________________________________
      > Do You Yahoo!?
      > Send online invitations with Yahoo! Invites.
      > http://invites.yahoo.com
      >
      >
      > ________________________________________________________________________
      > ________________________________________________________________________
      >
      > Message: 13
      > Date: Tue, 18 Apr 2000 18:06:03 -0700 (PDT)
      > From: Constance Dickson <constance_clearwater_florida@...>
      > Subject: Re: Doc, I need your opinion, please
      >
      > oh and also my 18 yr old daughter will be with me just
      > hope I have enough money together I don't want to ask
      > for help
      >
      > --- alley/Patricia <alleypat@...> wrote:
      > > Connie for those willing, I think treatment should
      > > be available. But that's
      > > just my opinion. So tell us what is in Georgia for
      > > you? I hope you have
      > > someone to stay with. schering can get you the
      > > treatment then you gotta find
      > > a way to get the tests. Let us know what is
      > > happening.
      > > alley/Patricia
      > > ICQ 12631861
      > > alleypat@...
      > > http://www.flash.net/~alleypat
      > >
      > >
      >
      > __________________________________________________
      > Do You Yahoo!?
      > Send online invitations with Yahoo! Invites.
      > http://invites.yahoo.com
      >
      >
      > ________________________________________________________________________
      > ________________________________________________________________________
      >
      > Message: 14
      > Date: Wed, 19 Apr 2000 07:48:56 +0530
      > From: "Doc" <gidoc@...>
      > Subject: Re: Muscle Spasms
      >
      > Hi Susan,
      >
      > Are you on Interferon , for that may cause muscle pains.
      > Or else electrolyte imbalance in Cirrhosis can also be one of the cause
      > . You must eat a protein rich diet with adequate calories and
      > electrolytes. And do not push yourself hard. Cirrhosis does produce
      > fatigue.
      >
      > Dr Sharat C Misra MD, DM
      > Consultant Gastroenterologist & Hepatologist
      >
      >
      >
      >
      > ----- Original Message -----
      > From: "Susan Jackson" <suejacks@...>
      > To: <GIWorld-Hepatitis@onelist.com>
      > Sent: Tuesday, April 18, 2000 8:21 AM
      > Subject: [GIWorld-Hepatitis] Muscle Spasms
      >
      >
      > > Hi Doc,
      > > I would like to ask about muscle spasms, that causes a numbness in my
      > arms.
      > > It only happens when I push myself, and become tired. This usually
      > means
      > > when I am working. I have cirrosis and varices.
      > > Is it because my body is weak? Is it common?
      > >
      > > Thanks,
      > > Sue
      > > suejacks@...
      > >
      > >
      > >
      > > ----------------------------------------------------------------------
      > ----------
      > >
      > >
      > >
      > > ----------------------------------------------------------------------
      > ----------
      > > Community email addresses:
      > > Post message: GIWorld-Hepatitis@onelist.com
      > > Subscribe: GIWorld-Hepatitis-subscribe@onelist.com
      > > Unsubscribe: GIWorld-Hepatitis-unsubscribe@onelist.com
      > > List owner: GIWorld-Hepatitis-owner@onelist.com
      > >
      > > Shortcut URL to this page:
      > > http://www.onelist.com/community/GIWorld-Hepatitis
      > >
      > >
      >
      >
      >
      >
      > ________________________________________________________________________
      > ________________________________________________________________________
      >
      > Message: 15
      > Date: Wed, 19 Apr 2000 07:45:25 +0530
      > From: "Doc" <gidoc@...>
      > Subject: Re: Doc, I need your opinion, please
      >
      > Hi Constance,
      >
      > Read my response where there is a *
      >
      > ----- Original Message -----
      > From: "Constance Dickson" <constance_clearwater_florida@...>
      > To: "'GIWorld-Hepatitis@egroups.com' Hep "
      > <giworld-hepatitis@egroups.com>
      > Sent: Wednesday, April 19, 2000 2:23 AM
      > Subject: [GIWorld-Hepatitis] Doc, I need your opinion, please
      >
      >
      > > I saw the Dr today. The one that I did not have much
      > > faith in. Well, he is pulling me off conbo or
      > > anythiny else till maybe something new comes up. You
      > > probably don't remember but, I am the one who lost my
      > > job and insurance and had to go off meds. when I
      > > first started Combo 3/99 my viral load was 12 million
      > > and ALT and ASL's were high but do not remember them.
      > > They had dropped in mid September to 300,000 viral
      > > load and 50/60 range for liver functions. Well now my
      > > viral load is 29 million he has not got the ALT or AST
      > > back, but in mid Nov/99 they were up to the 120-140
      > > range. He told me it would be useless to go back on
      > > the combo because I am a non responder. Dr I had when
      > > I had insurance and in Clearwater FL (not in this
      > > armpit of FL place Inverness, FL) said he hated to
      > > pull me off them because I was responding quite well
      > > from the Combo,when I lost my insurance, was pulled
      > > because of monitoring of my blood that was needed.
      > > I do now have the biopsy report that was done
      > > 3/30/99,
      > > I will put down on here what it says.
      > > GROSS: received are two portions of yellow gray
      > > cylindrical measuring to 1.2 to 1.7 in lenght to 0.1
      > > to 0.2 cm in diameter. Entirely submitted. rh/ms.
      > >
      > > MICRO: Examination of this hepatic tissue discloses
      > > no evidence of pigment,granuloma, or metastatic tumor.
      > > I do not see acidophil bodies or spotty individual
      > > cell necrosis. Only an occasional focus of lobular
      > > hepatitis is noted.There is quite varuable involvement
      > > of portal tracts with inflammatory cells: however,
      > > some of these portal tracts are very markedly widened
      > > secondary to the presence of lymphocytes with an
      > > occasional plasma cell. These Lymphocytes tend to
      > > extend outward into the hepatic parenchyma and
      > > encircle hepatic cells, forming marked uneveness of
      > > the limiting plate. Examination of a Trichome
      > > preparation documents the variability of portal tract
      > > involement with Fibrosis; however, there is an example
      > > of marked septal-to-septal fibroses without distortion
      > > of surrounding architecture.
      > >
      > > Daignoses
      > > Liver Biopsy: Chonic Hepatitis
      > > Moderate periportal inflammation, grade 3.
      > > Inflammation without necrosis, grade 1
      > > Periportal fibrosis with portal-to-portal septa, with
      > > intact architecture stage 2
      >
      > * You have significant chr hep C , HAI being above 3, and a high viral
      > load thus you are a candidate for therapy.
      >
      > > I have 2 and 1/2 months of Combo in the refridgerator
      > > do you think I should stop all treatments? I have not
      > > been on Combo since 10/1/99. I am going to move to GA
      > > next week near Macon and try to get some kind of
      > > medical help there. Please let me know what to do.
      >
      > * No, you need to be on a high dose daily IFN( induction thearpy) and
      > Ribavirin, so do not go back to old regime, which failed.
      >
      > > On Genotypes what is the causing factor for certain
      > > types. Also what does the dainoses of biopsy mean. I
      > > don't think I should just give up.
      >
      > * You have no cirrhosis and that is a very good sign, you must take
      > treatment.
      >
      > He wants to see me
      > > in 6 months this new Dr. From the first I had no
      > > faith in him when I had to take script back into him
      > > before leaving to remind him to put Quanitive and
      > > something else on it that I forget at this moment.
      > > ............Connie
      > > I am also Genotybe 1a.
      >
      > * You need to be on a full year of therapy again as early as possible,
      > why the wait of six months? 1 a is difficult to beat but not impossible
      > !
      >
      > Dr Sharat C Misra MD, DM
      > Consultant Gastroenterologist & Hepatologist
      >
      >
      >
      >
      >
      > ________________________________________________________________________
      > ________________________________________________________________________
      >
      > Message: 16
      > Date: Wed, 19 Apr 2000 07:32:35 +0530
      > From: "Doc" <gidoc@...>
      > Subject: Re:
      >
      > Write what your problem is.
      >
      > Dr Sharat C Misra MD, DM
      > Consultant Gastroenterologist & Hepatologist
      >
      > ----- Original Message -----
      > From: <RIVERJORDAN@...>
      > To: <GIWorld-Hepatitis@onelist.com>
      > Sent: Wednesday, April 19, 2000 12:29 PM
      > Subject: [GIWorld-Hepatitis]
      >
      >
      > > Hello,
      > >
      > > I see that there be lots of those that are in dicussions of hep-c and
      > side
      > > effects. Could there be anyone here with cryptogenic cirrhosis? It
      > would be a
      > > blessing if one would give me a response.
      > >
      > > Cherokee
      > > Crosswaters
      > >
      > > _____________________________________________
      > > Free email with cool domains at FriendlyEmail
      > > http://www.mypad.com/
      > >
      > >
      > >
      > > ----------------------------------------------------------------------
      > ----------
      > >
      > >
      > >
      > > ----------------------------------------------------------------------
      > ----------
      > > Community email addresses:
      > > Post message: GIWorld-Hepatitis@onelist.com
      > > Subscribe: GIWorld-Hepatitis-subscribe@onelist.com
      > > Unsubscribe: GIWorld-Hepatitis-unsubscribe@onelist.com
      > > List owner: GIWorld-Hepatitis-owner@onelist.com
      > >
      > > Shortcut URL to this page:
      > > http://www.onelist.com/community/GIWorld-Hepatitis
      > >
      > >
      >
      >
      >
      >
      > ________________________________________________________________________
      > ________________________________________________________________________
      >
      > Message: 17
      > Date: Tue, 18 Apr 2000 21:44:22 CDT
      > From: "Claudine Crews" <claudinecrews@...>
      > Subject: VIRUS ALERT/Off Topic
      >
      > VIRUS ALERT
      >
      >
      >
      > >Some very nasty viruses out there. These are very new and dangerous
      > >
      >
      >
      >
      > >
      > >PASS THIS ON TO EVERYONE IMMEDIATELY!!!
      > > > > >> > > > >
      > > > > >> > > > > WARNING NO. 1
      > > > > >> > > > >
      > > > > >> > > > > If you receive any CELCOM Screen Saver Please do
      > > > > >> > > > > not install It!!!!!! This screen saver is very
      > > > > >> > > > > cool. It shows
      > > > > >> > > > > a NOKIA hand phone, with time messages. After it is
      > > > > >> > > > > activated, the PC cannot boot up at all. It goes
      > > > > >> > > > > very slow.
      > > > > >> > > > > It destroys your hard disk. The filename is
      > > > > >> > > > >
      > > > > >> > > > > CELLSAVER.EXE
      > > > > >> > > > >
      > > > > >> > > > > WARNING NO. 2
      > > > > >> > > > >
      > > > > >> > > > > Beware! If someone named <SandMan asks you to
      > > > > >> > > > > check out his page. DO NOT! It is at
      > > > > >> > > > >
      > > > > > >> > > > >
      > > > > >> > > > > This page hacks into your C:\drive. DO NOT GO THERE.
      > > > > >> > > > > FORWARD THIS MAIL TO EVERYONE YOU KNOW.
      > > > > >> > > > >
      > > > > >> > > > > WARNING NO. 3
      > > > > >> > > > >
      > > > > >> > > > > WARNING: If you get a E-mail titled : "Win A
      > > > > >> > > > > Holiday"
      > > > > >> > > > > DO NOT open it. Delete it immediately. Microsoft
      > > > > >> > > > > just
      > > > > >> > > > > announced yesterday. It is a malicious virus that
      > > > > >> > > > > WILL
      > > > > >> > > > > ERASE YOUR HARD DRIVE. At this time there is
      > > > > >> > > > > no remedy. Forward this to everyone IMMEDIATELY!
      > > > > >> > > > >
      > > > > >> > > > > PLEASE PASS THIS ALONG TO ALL YOUR FRIENDS AND
      > > > > >> > > > > PEOPLE IN YOUR MAILBOXES.
      >
      >
      >
      > ______________________________________________________
      > Get Your Private, Free Email at http://www.hotmail.com
      >
      >
      >
      > ________________________________________________________________________
      > ________________________________________________________________________
      >
      > Message: 18
      > Date: Tue, 18 Apr 2000 22:50:08 EDT
      > From: srw1954@...
      > Subject: 24 vs. 48 weeks controversy
      >
      > Hi Dr Misra and everyone,
      > I saw my doctor, Dr. Robert Gish, today for my "after-treatment follow-up
      and
      > action plan" as I like to call it. To refresh your memories, I am a
      white,
      > 45 yr. old, type 2B female, with a Stage 3/Grade 2 biopsy and a 5 million
      > viral load before starting 6 months of combo treatment on 10/18/99 that
      just
      > ended 15 days ago, and "non-detectable" at 12 weeks and now at 24 weeks
      (end
      > of treatment on 4/3/00).
      > Dr. Gish said that my viral load, LFT's, etc. are all looking great, and
      so,
      > unless I take a turn for the worse, he wants to recheck all my bloodwork,
      > including viral load, and see me again in 6 months (Sept/October 2000).
      He
      > expects I'll be continuing to feel better gradually since I'm still
      feeling
      > some of my side effects, although a bit milder than while on treatment.
      If I
      > am a "sustained responder" (still non-detectable) 6 months from now then
      he
      > said there is a 95% chance of continued success beyond that, and he would
      > check me again about 2 years after that (again, unless I have problems).
      We
      > didn't talk about it today, but last month he had indicated that if I was
      not
      > a sustained responder then he would probably try me on the Pegylated
      > interferon later this year.
      > I told him I had heard on the Internet hep c sites that a study came out
      > about a new protocol, where there are 5 factors determining whether a type
      2
      > or 3 should/would go for 24 weeks or 48. He said that he had heard about
      the
      > study, but he usually only recommends 48 weeks for a type 2 or 3 when they
      > have at least borderline cirrhosis. He said that equated to only about 1%
      of
      > hep c patients that would fall within those recommendations. He then said
      > that my treatment plan was appropriate. We did not discuss type 1's at
      all,
      > sorry.
      > This will probably continue to be a controversy, as so much about hep c
      is,
      > so let's keep the information flowing so we're all kept current.
      > Take care everyone,
      > Sara
      >
      > (the above message was in response to these emails) :
      > > Date: Sun, 16 Apr 2000 15:09:10 +0530
      > > From: "Doc" <gidoc@...>
      > > Subject: Re:
      > > Hi all,
      > > I must add here that Dr Hoofnagle is a pioneer on treatment of
      Hepatitis
      > > and we must value his judgment. However, the results of various
      > > studies are not really applicable to one and all. It has been proven
      now
      > > that the longer you take treatment for Hep C the more likely are you to
      > > remain in remission. Thus irrespective of genotype treatment is
      > > certainly to be continued for a year unless you are getting serious
      side
      > > effects or have minimal damage on liver biopsy which has reversed.
      > > Remember the virus develops new quasispecies real fast the moment you
      > > discontinue treatment.
      > > Dr Sharat C Misra, MD DM
      > > Consultant Gastroenterologist & Hepatologist
      > >
      > > ----- Original Message -----
      > > From: "Claudine Crews" <claudinecrews@...>
      > > To: <GIWorld-Hepatitis@onelist.com>
      > > Sent: Sunday, April 16, 2000 2:01 PM
      > > Subject: [GIWorld-Hepatitis] (unknown)
      > >
      > > > Hello Everyone,
      > > > I wanted to share the following with all of you. In a message
      > > > yesterday (?) someone said their doctor said genotypes 2 & 3 never
      > > should be on combo more than 6 months, and 1's with viral loads under 2
      > million
      > > should only be on 6 months too. I sent a question in to another HCV
      group
      > > that is huge, and got an interesting response. This response if from
      > someone
      > > who is extremely well educated about HCV and has a medical background,
      and
      > I
      > > have come to respect his opinions and advice. Due to privacy issues
      and
      > > list rules I cannot print any of his personal info, but still thought
      you
      > > might enjoy hearing what he had to say. The first part is the question
      I
      > > sent in.
      > > >
      > > > Hi everyone,
      > > > Could y'all read the following letter and tell me if ANYONE has
      > > heard anything about this supposed study? (not the French study
      mentioned,
      > > the following one on reducing the length of treatment.) I can't
      believe
      > > anyone would be saying that genotype 1's with viral loads under 2
      million
      > > should only be treated 6 months, unless maybe the person worked for
      > Schering.
      > > I'm sure they would like a bunch of relapsers to buy more drugs.
      > > > Claudine
      > > >
      > > > ****************************
      > > > ..... I will really be interested to hear what Dr. Gish says about
      the
      > > length of treatment next week....I am a 2 b and had resigned myself to
      48
      > weeks
      > > of treatment because that's what the five factor thingy (from the
      French
      > > > study?) seemed to indicate for me....I only had 3 positive factors:
      > female,
      > > 1.5 - 2 mil viral load, and non-African....Against me is age (53),
      disease
      > 30
      > > years, and stage 2 fibrosis (approaching stage 3?) Well......my hep
      doc
      > just
      > > got back from a symposium on liver disease in Atlanta put on by the
      > > CDC....He said Dr. Hofnagel (sp?) made an announcement that new studies
      > indicate that genotype 2's and 3's should never go longer than 6
      > months....there is
      > > never an advantage....NOW I'M REALLY CONFUSED.......and I wonder if
      this
      > is
      > > just a different interpretation of the study that proposed the five
      > positive
      > > factor gauge......DOES ANYBODY KNOW WHAT MY DOC IS TALKING ABOUT???
      Can
      > anyone tell me if this information from Dr. Hofnagel is really new? ****
      > > Supposedly, he said that even genotype 1's should quit after 6 months
      of
      > treatment if they started with a viral load of 2 mil or less....What's a
      girl
      > to believe? I'd appreciate any clarification of this info....I don't know
      > whether to quit or not......Thanks,
      > > >
      > >
      > ----------------------------------------------------------------------
      > > > Claudine, This is all hogwash. I have not seen any new Hoofnagel
      > > info, but these kinds of absolute statements are absolute nonsense.
      The
      > > only absolute about Hep C and its treatments are that there are no
      > absolutes.
      > > > Since Hoofnagel is the dope that gave us 12 years of mistreatment
      with
      > > 3 times weekly dosing I'd have to take anything he says with a LOT of
      salt.
      > > > Any genotype 1 that quits treatment after 6 months is begging for
      > > failure or relapse. I'd consider 6 months of treatment for a genotype
      1
      > as pure
      > > folly, regardless of beginning viral load. (Although there's no
      question
      > > that the lower viral load will fare better... across the board.)
      > > > And to say genotypes 2 or 3 should NEVER go beyond 6 months is just
      as
      > > > stupid, or more so. What should be the measure of the length of
      > > treatment is to use viral load tests, and to treat genotypes 2 or 3 for
      at
      > least
      > > 5 months after viral clearance (but preferably 9 or 10 months), and
      > > genotype 1a for 10 or 11 months after viral clearance. Genotype 1b's
      > should go
      > > for about 15 months past viral clearance.
      > > > Using viral clearance as a guidepost to treatment duration is by far
      > > the best way to determine length of treatment, but even that is no
      > > assurance of certainty. And the other pretreatment factors also have
      to
      > be taken
      > > into account when trying to approximate treatment durations.
      > > > Of course these guidelines are for the Schering Combo on standard
      doses.
      > > > Daily dosing will at least double the chances of obtaining success
      for
      > > any patient.
      > > > Warm regards,
      > > > xxxxx
      >
      >
      > ________________________________________________________________________
      > ________________________________________________________________________
      >
      > Message: 19
      > Date: Tue, 18 Apr 2000 19:52:53 -0700 (PDT)
      > From: Constance Dickson <constance_clearwater_florida@...>
      > Subject: Re: Doc, I need your opinion, please
      >
      > He said it would be useless for me to go on it again.
      > I thought he was wrong myself and told him and he said
      > well that is the recommended treatment now. For me
      > just to wait till something new comes out........Thank
      > you Doc I am a bit down about this, I don't know how
      > bad it is and I am scared if I wait for something new
      > maybe it might be to late....Connie
      > He is not a nery good Dr I formed that opinion the
      > first time I saw him Dr Hellstern here in
      > Inverness.....Dr Sreenath in Clearwater was a good
      > one.
      > I wonder if my $500 share of cost (I pay first $500
      > each month) with Medicaid has anything to do with it.
      > I know they do not pay out as much as regular
      > insurance does....Thanks Doc I am moving near Macon
      > any suggestions?
      > --- Doc <gidoc@...> wrote:
      > > Hi Constance,
      > >
      > > Read my response where there is a *
      > >
      > > ----- Original Message -----
      > > From: "Constance Dickson"
      > > <constance_clearwater_florida@...>
      > > To: "'GIWorld-Hepatitis@egroups.com' Hep "
      > > <giworld-hepatitis@egroups.com>
      > > Sent: Wednesday, April 19, 2000 2:23 AM
      > > Subject: [GIWorld-Hepatitis] Doc, I need your
      > > opinion, please
      > >
      > >
      > > > I saw the Dr today. The one that I did not have
      > > much
      > > > faith in. Well, he is pulling me off conbo or
      > > > anythiny else till maybe something new comes up.
      > > You
      > > > probably don't remember but, I am the one who lost
      > > my
      > > > job and insurance and had to go off meds. when I
      > > > first started Combo 3/99 my viral load was 12
      > > million
      > > > and ALT and ASL's were high but do not remember
      > > them.
      > > > They had dropped in mid September to 300,000 viral
      > > > load and 50/60 range for liver functions. Well
      > > now my
      > > > viral load is 29 million he has not got the ALT or
      > > AST
      > > > back, but in mid Nov/99 they were up to the
      > > 120-140
      > > > range. He told me it would be useless to go back
      > > on
      > > > the combo because I am a non responder. Dr I had
      > > when
      > > > I had insurance and in Clearwater FL (not in this
      > > > armpit of FL place Inverness, FL) said he hated to
      > > > pull me off them because I was responding quite
      > > well
      > > > from the Combo,when I lost my insurance, was
      > > pulled
      > > > because of monitoring of my blood that was needed.
      > > > I do now have the biopsy report that was done
      > > > 3/30/99,
      > > > I will put down on here what it says.
      > > > GROSS: received are two portions of yellow gray
      > > > cylindrical measuring to 1.2 to 1.7 in lenght to
      > > 0.1
      > > > to 0.2 cm in diameter. Entirely submitted. rh/ms.
      > > >
      > > > MICRO: Examination of this hepatic tissue
      > > discloses
      > > > no evidence of pigment,granuloma, or metastatic
      > > tumor.
      > > > I do not see acidophil bodies or spotty individual
      > > > cell necrosis. Only an occasional focus of
      > > lobular
      > > > hepatitis is noted.There is quite varuable
      > > involvement
      > > > of portal tracts with inflammatory cells: however,
      > > > some of these portal tracts are very markedly
      > > widened
      > > > secondary to the presence of lymphocytes with an
      > > > occasional plasma cell. These Lymphocytes tend to
      > > > extend outward into the hepatic parenchyma and
      > > > encircle hepatic cells, forming marked uneveness
      > > of
      > > > the limiting plate. Examination of a Trichome
      > > > preparation documents the variability of portal
      > > tract
      > > > involement with Fibrosis; however, there is an
      > > example
      > > > of marked septal-to-septal fibroses without
      > > distortion
      > > > of surrounding architecture.
      > > >
      > > > Daignoses
      > > > Liver Biopsy: Chonic Hepatitis
      > > > Moderate periportal inflammation, grade 3.
      > > > Inflammation without necrosis, grade 1
      > > > Periportal fibrosis with portal-to-portal septa,
      > > with
      > > > intact architecture stage 2
      > >
      > > * You have significant chr hep C , HAI being above
      > > 3, and a high viral
      > > load thus you are a candidate for therapy.
      > >
      > > > I have 2 and 1/2 months of Combo in the
      > > refridgerator
      > > > do you think I should stop all treatments? I have
      > > not
      > > > been on Combo since 10/1/99. I am going to move to
      > > GA
      > > > next week near Macon and try to get some kind of
      > > > medical help there. Please let me know what to
      > > do.
      > >
      > > * No, you need to be on a high dose daily IFN(
      > > induction thearpy) and
      > > Ribavirin, so do not go back to old regime, which
      > > failed.
      > >
      > > > On Genotypes what is the causing factor for
      > > certain
      > > > types. Also what does the dainoses of biopsy
      > > mean. I
      > > > don't think I should just give up.
      > >
      > > * You have no cirrhosis and that is a very good
      > > sign, you must take
      > > treatment.
      > >
      > > He wants to see me
      > > > in 6 months this new Dr. From the first I had no
      > > > faith in him when I had to take script back into
      > > him
      > > > before leaving to remind him to put Quanitive and
      > > > something else on it that I forget at this moment.
      > > > ............Connie
      > > > I am also Genotybe 1a.
      > >
      > > * You need to be on a full year of therapy again as
      > > early as possible,
      > > why the wait of six months? 1 a is difficult to beat
      > > but not impossible
      > > !
      > >
      > > Dr Sharat C Misra MD, DM
      > > Consultant Gastroenterologist & Hepatologist
      > >
      > >
      > >
      > >
      >
      > __________________________________________________
      > Do You Yahoo!?
      > Send online invitations with Yahoo! Invites.
      > http://invites.yahoo.com
      >
      >
      > ________________________________________________________________________
      > ________________________________________________________________________
      >
      > Message: 20
      > Date: Tue, 18 Apr 2000 20:18:08 -0700 (PDT)
      > From: Constance Dickson <constance_clearwater_florida@...>
      > Subject: Re: Doc, I need your opinion, please
      >
      > I don't want to sound dumb but, what is HAI?
      >
      > --- Doc <gidoc@...> wrote:
      > > Hi Constance,
      > >
      > > Read my response where there is a *
      > >
      > > ----- Original Message -----
      > > From: "Constance Dickson"
      > > <constance_clearwater_florida@...>
      > > To: "'GIWorld-Hepatitis@egroups.com' Hep "
      > > <giworld-hepatitis@egroups.com>
      > > Sent: Wednesday, April 19, 2000 2:23 AM
      > > Subject: [GIWorld-Hepatitis] Doc, I need your
      > > opinion, please
      > >
      > >
      > > > I saw the Dr today. The one that I did not have
      > > much
      > > > faith in. Well, he is pulling me off conbo or
      > > > anythiny else till maybe something new comes up.
      > > You
      > > > probably don't remember but, I am the one who lost
      > > my
      > > > job and insurance and had to go off meds. when I
      > > > first started Combo 3/99 my viral load was 12
      > > million
      > > > and ALT and ASL's were high but do not remember
      > > them.
      > > > They had dropped in mid September to 300,000 viral
      > > > load and 50/60 range for liver functions. Well
      > > now my
      > > > viral load is 29 million he has not got the ALT or
      > > AST
      > > > back, but in mid Nov/99 they were up to the
      > > 120-140
      > > > range. He told me it would be useless to go back
      > > on
      > > > the combo because I am a non responder. Dr I had
      > > when
      > > > I had insurance and in Clearwater FL (not in this
      > > > armpit of FL place Inverness, FL) said he hated to
      > > > pull me off them because I was responding quite
      > > well
      > > > from the Combo,when I lost my insurance, was
      > > pulled
      > > > because of monitoring of my blood that was needed.
      > > > I do now have the biopsy report that was done
      > > > 3/30/99,
      > > > I will put down on here what it says.
      > > > GROSS: received are two portions of yellow gray
      > > > cylindrical measuring to 1.2 to 1.7 in lenght to
      > > 0.1
      > > > to 0.2 cm in diameter. Entirely submitted. rh/ms.
      > > >
      > > > MICRO: Examination of this hepatic tissue
      > > discloses
      > > > no evidence of pigment,granuloma, or metastatic
      > > tumor.
      > > > I do not see acidophil bodies or spotty individual
      > > > cell necrosis. Only an occasional focus of
      > > lobular
      > > > hepatitis is noted.There is quite varuable
      > > involvement
      > > > of portal tracts with inflammatory cells: however,
      > > > some of these portal tracts are very markedly
      > > widened
      > > > secondary to the presence of lymphocytes with an
      > > > occasional plasma cell. These Lymphocytes tend to
      > > > extend outward into the hepatic parenchyma and
      > > > encircle hepatic cells, forming marked uneveness
      > > of
      > > > the limiting plate. Examination of a Trichome
      > > > preparation documents the variability of portal
      > > tract
      > > > involement with Fibrosis; however, there is an
      > > example
      > > > of marked septal-to-septal fibroses without
      > > distortion
      > > > of surrounding architecture.
      > > >
      > > > Daignoses
      > > > Liver Biopsy: Chonic Hepatitis
      > > > Moderate periportal inflammation, grade 3.
      > > > Inflammation without necrosis, grade 1
      > > > Periportal fibrosis with portal-to-portal septa,
      > > with
      > > > intact architecture stage 2
      > >
      > > * You have significant chr hep C , HAI being above
      > > 3, and a high viral
      > > load thus you are a candidate for therapy.
      > >
      > > > I have 2 and 1/2 months of Combo in the
      > > refridgerator
      > > > do you think I should stop all treatments? I have
      > > not
      > > > been on Combo since 10/1/99. I am going to move to
      > > GA
      > > > next week near Macon and try to get some kind of
      > > > medical help there. Please let me know what to
      > > do.
      > >
      > > * No, you need to be on a high dose daily IFN(
      > > induction thearpy) and
      > > Ribavirin, so do not go back to old regime, which
      > > failed.
      > >
      > > > On Genotypes what is the causing factor for
      > > certain
      > > > types. Also what does the dainoses of biopsy
      > > mean. I
      > > > don't think I should just give up.
      > >
      > > * You have no cirrhosis and that is a very good
      > > sign, you must take
      > > treatment.
      > >
      > > He wants to see me
      > > > in 6 months this new Dr. From the first I had no
      > > > faith in him when I had to take script back into
      > > him
      > > > before leaving to remind him to put Quanitive and
      > > > something else on it that I forget at this moment.
      > > > ............Connie
      > > > I am also Genotybe 1a.
      > >
      > > * You need to be on a full year of therapy again as
      > > early as possible,
      > > why the wait of six months? 1 a is difficult to beat
      > > but not impossible
      > > !
      > >
      > > Dr Sharat C Misra MD, DM
      > > Consultant Gastroenterologist & Hepatologist
      > >
      > >
      > >
      > >
      >
      > __________________________________________________
      > Do You Yahoo!?
      > Send online invitations with Yahoo! Invites.
      > http://invites.yahoo.com
      >
      >
      > ________________________________________________________________________
      > ________________________________________________________________________
      >
      > Message: 21
      > Date: Tue, 18 Apr 2000 22:29:20 -0500
      > From: "Donna Graham" <donnaliz2@...>
      > Subject: Subject: NAOMI
      >
      > Who knows, but they say 15% of us clear the virus with no intervention or
      treatment. So call it luck or prayer or magic - who knows?
      >
      > From: kalidurga@...
      > I thought she said she cured herself through prayer? Does anyone know
      > the real deal
      >
      >
      >
      >
      > [Non-text portions of this message have been removed]
      >
      >
      >
      > ________________________________________________________________________
      > ________________________________________________________________________
      >
      > Message: 22
      > Date: Tue, 18 Apr 2000 20:53:15 -0700 (PDT)
      > From: Constance Dickson <constance_clearwater_florida@...>
      > Subject: Re: 24 vs. 48 weeks controversy
      >
      > Congratulations Sara I am very happy for you I hope
      > everything stays good for you. It took about 3 months
      > when I was pulled off meds to feel normal or kind of
      > normal again so hopefully yours will come quicker and
      > stay that way.......Connie
      >
      > --- srw1954@... wrote:
      > > Hi Dr Misra and everyone,
      > > I saw my doctor, Dr. Robert Gish, today for my
      > > "after-treatment follow-up and
      > > action plan" as I like to call it. To refresh your
      > > memories, I am a white,
      > > 45 yr. old, type 2B female, with a Stage 3/Grade 2
      > > biopsy and a 5 million
      > > viral load before starting 6 months of combo
      > > treatment on 10/18/99 that just
      > > ended 15 days ago, and "non-detectable" at 12 weeks
      > > and now at 24 weeks (end
      > > of treatment on 4/3/00).
      > > Dr. Gish said that my viral load, LFT's, etc. are
      > > all looking great, and so,
      > > unless I take a turn for the worse, he wants to
      > > recheck all my bloodwork,
      > > including viral load, and see me again in 6 months
      > > (Sept/October 2000). He
      > > expects I'll be continuing to feel better gradually
      > > since I'm still feeling
      > > some of my side effects, although a bit milder than
      > > while on treatment. If I
      > > am a "sustained responder" (still non-detectable) 6
      > > months from now then he
      > > said there is a 95% chance of continued success
      > > beyond that, and he would
      > > check me again about 2 years after that (again,
      > > unless I have problems). We
      > > didn't talk about it today, but last month he had
      > > indicated that if I was not
      > > a sustained responder then he would probably try me
      > > on the Pegylated
      > > interferon later this year.
      > > I told him I had heard on the Internet hep c sites
      > > that a study came out
      > > about a new protocol, where there are 5 factors
      > > determining whether a type 2
      > > or 3 should/would go for 24 weeks or 48. He said
      > > that he had heard about the
      > > study, but he usually only recommends 48 weeks for a
      > > type 2 or 3 when they
      > > have at least borderline cirrhosis. He said that
      > > equated to only about 1% of
      > > hep c patients that would fall within those
      > > recommendations. He then said
      > > that my treatment plan was appropriate. We did not
      > > discuss type 1's at all,
      > > sorry.
      > > This will probably continue to be a controversy, as
      > > so much about hep c is,
      > > so let's keep the information flowing so we're all
      > > kept current.
      > > Take care everyone,
      > > Sara
      > >
      > > (the above message was in response to these emails)
      > > :
      > > > Date: Sun, 16 Apr 2000 15:09:10 +0530
      > > > From: "Doc" <gidoc@...>
      > > > Subject: Re:
      > > > Hi all,
      > > > I must add here that Dr Hoofnagle is a pioneer on
      > > treatment of Hepatitis
      > > > and we must value his judgment. However, the
      > > results of various
      > > > studies are not really applicable to one and all.
      > > It has been proven now
      > > > that the longer you take treatment for Hep C the
      > > more likely are you to
      > > > remain in remission. Thus irrespective of
      > > genotype treatment is
      > > > certainly to be continued for a year unless you
      > > are getting serious side
      > > > effects or have minimal damage on liver biopsy
      > > which has reversed.
      > > > Remember the virus develops new quasispecies real
      > > fast the moment you
      > > > discontinue treatment.
      > > > Dr Sharat C Misra, MD DM
      > > > Consultant Gastroenterologist & Hepatologist
      > > >
      > > > ----- Original Message -----
      > > > From: "Claudine Crews"
      > > <claudinecrews@...>
      > > > To: <GIWorld-Hepatitis@onelist.com>
      > > > Sent: Sunday, April 16, 2000 2:01 PM
      > > > Subject: [GIWorld-Hepatitis] (unknown)
      > > >
      > > > > Hello Everyone,
      > > > > I wanted to share the following with all
      > > of you. In a message
      > > > > yesterday (?) someone said their doctor said
      > > genotypes 2 & 3 never
      > > > should be on combo more than 6 months, and 1's
      > > with viral loads under 2
      > > million
      > > > should only be on 6 months too. I sent a
      > > question in to another HCV group
      > > > that is huge, and got an interesting response.
      > > This response if from
      > > someone
      > > > who is extremely well educated about HCV and has
      > > a medical background, and
      > > I
      > > > have come to respect his opinions and advice.
      > > Due to privacy issues and
      > > > list rules I cannot print any of his personal
      > > info, but still thought you
      > > > might enjoy hearing what he had to say. The
      > > first part is the question I
      > > > sent in.
      > > > >
      > > > > Hi everyone,
      > > > > Could y'all read the following letter and
      > > tell me if ANYONE has
      > > > heard anything about this supposed study? (not
      > > the French study mentioned,
      > > > the following one on reducing the length of
      > > treatment.) I can't believe
      > > > anyone would be saying that genotype 1's with
      > > viral loads under 2 million
      > > > should only be treated 6 months, unless maybe the
      > > person worked for
      > > Schering.
      > > > I'm sure they would like a bunch of relapsers to
      > > buy more drugs.
      > > > > Claudine
      > > > >
      > > > > ****************************
      > > > > ..... I will really be interested to hear what
      > > Dr. Gish says about the
      > > > length of treatment next week....I am a 2 b and
      > > had resigned myself to 48
      > > weeks
      > > > of treatment because that's what the five factor
      > > thingy (from the French
      > > > > study?) seemed to indicate for me....I only had
      > > 3 positive factors:
      > > female,
      > > > 1.5 - 2 mil viral load, and
      > > non-African....Against me is age (53), disease
      > > 30
      > > > years, and stage 2 fibrosis (approaching stage
      > > 3?) Well......my hep doc
      > > just
      > > > got back from a symposium on liver disease in
      > > Atlanta put on by the
      > > > CDC....He said Dr. Hofnagel (sp?) made an
      > > announ<br/><br/>(Message over 64 KB, truncated)
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