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INFO: Extrahepatic Manifestations of Chronic HCV/Rer Arkh 1998

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  • Claudine Crews
    [Extrahepatic manifestations of chronic hepatitis C] VERNACULAR TITLE: Vnepechenochnye proiavleniia khronicheskogo gepatita C. AUTHORS: Ignatova TM; Aprosina
    Message 1 of 1 , Apr 27, 2000
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      [Extrahepatic manifestations of chronic hepatitis C]
      VERNACULAR TITLE:
      Vnepechenochnye proiavleniia khronicheskogo gepatita C.

      AUTHORS: Ignatova TM; Aprosina ZG; Serov VV; Mukhin NA; Krel'PE;Semenkova
      EN;PopovaIV; Tanashchuk EL

      SOURCE:
      Ter Arkh 1998;70(11):9-16
      CITATION IDS:
      PMID: 9949448 UI: 99134607
      ABSTRACT: AIM: To study incidence, special features and mechanisms
      underlying onset of extrahepatic lesions in HCV-infection.

      MATERIALS AND METHODS: Extrahepatic symptoms of chronic hepatitis C and its
      outcome--hepatic cirrhosis were studied in 157 patients. HCV-infection was
      confirmed by ELISA II and polymerase chain reaction (detection in the serum
      of anti-HCV and HCVRNA, respectively).
      Morphological studies of the liver were made in 134 patients, of other
      organs and tissues--in 20 patients. Immunological tests were made in 124
      patients. Thyroid hormones, antibodies to thyroglobuline were
      measured with radioimmunoassay in 74 patients.

      RESULTS: Extrahepatic manifestations were found in 70(44.6%) patients
      with chronic hepatitis C (more frequently in hepatic cirrhosis), for the
      most part in women and in long-lasting disease. 54(43.5%) women had
      cryoglobulinemia, 27 of them showed it clinically. Patients with
      cryoglobulinemia and free of it exhibited varying frequency cutaneous
      vasculitis, Raynaud's syndrome, affection of the muscles and joints, nodular
      periartheritis, lesions of the lungs, myocarditis, autoimmune thyroiditis,
      Sjogren's syndrome, lichen ruber planus, porphyria cutanea tarda, immune
      cytopenia, autoimmune hemolytic anemia, hypoplastic anemia, monoclonal
      immunoglobulinopathy, B-cell lymphoma. Of high frequency were activity of
      rheumatic factor (66.9%), hypocomplementemia (31.8%), antinuclear antibodies
      (9.8%) and other immunological disorders.

      CONCLUSION: Some extrahepatic lesions in HCV-infection are detailed:
      frequent mixed cryoglobulinemia and associated vasculitides of different
      sites, malignan lymphoproliferative diseases, more frequent
      than in HBV-infection involvement of the thyroid and salivary glands, some
      skin lesions.

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