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FW: NATAP: Noninvasive Tools for Fibrosis in Clinical Practice

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  • alleypat
    Hepatology Feb 2006 Use of Noninvasive Tools to Evaluate Liver Disease in Clinical Practice .....A number of non-invasive tests have been commercialized and
    Message 1 of 1 , Feb 3, 2006
      Hepatology
      Feb 2006

      Use of Noninvasive Tools to Evaluate Liver Disease in Clinical Practice


      ".....A number of non-invasive tests have been commercialized and are being
      used more and more in practice. Their use varies widely depending on
      practice setting and the individual physician's management style. For
      example, some physicians would treat all patients with HCV, with the
      possible exception of those with genotype 1 virus and minimal structural
      disease (fibrosis stage 0/1). For these, a non-invasive test that detects
      the absence of fibrosis with acceptable accuracy suffices and, moreover,
      saves the cost and morbidity of liver biopsy. Other physicians (and many
      patients), weighing the toxicity, limited efficacy, and cost of current
      interferon-based regimens, would reserve treatment for significant disease
      (fibrosis stage 2/3) or clear evidence of fibrosis progression.
      Decision-making in this case requires a test that differentiates minimal
      disease (stage 0/1 fibrosis) from intermediate fibrosis (stage 2/3). For
      this purpose, the current generation of non-invasive tests falls short, and
      liver biopsy still is needed for definitive staging. Fewer clinical data are
      available in patients with non-HCV chronic liver disease, and use of
      non-invasive tests is even more variable...."

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