Loading ...
Sorry, an error occurred while loading the content.

A Multicentre Study of the Usefulness of Liver Biopsy in Hepatitis C

Expand Messages
  • claudine intexas
    NOTE: To view the article with Web enhancements, go to: http://www.medscape.com/viewarticle/482406 ... A Multicentre Study of the Usefulness of Liver Biopsy in
    Message 1 of 1 , Aug 21 2:21 PM
    • 0 Attachment
      NOTE: To view the article with Web enhancements, go to:
      http://www.medscape.com/viewarticle/482406



      ---------------------------------

      A Multicentre Study of the Usefulness of Liver Biopsy in Hepatitis C

      V.G. Bain; M. Bonacini; S. Govindarajan; M. Ma; M. Sherman; A. Gibas; S.J. Cotler; M. Deschenes; K. Kaita; G.S. Jhangri
      J Viral Hepat 11(4):375-382, 2004. � 2004 Blackwell Publishing

      Posted 08/09/2004
      Summary
      The role of liver biopsy in the assessment of chronic hepatitis C is generally accepted yet there is no prospective data available to quantify its contribution. A previous single centre pilot study suggested that the clinician could predict the amount of fibrosis and to a lesser extent, inflammation with moderate accuracy. The 2002 National Institute of Health Hepatitis C Consensus Conference recommended further study of the role of liver biopsy. Our objective was to compare a prediction of biopsy findings by expert clinicians using usually available clinical and laboratory data to actual biopsy results in order to determine whether biopsy is required routinely. This was a prospective observational study conducted at seven university centres in which the accuracy of clinician's predictions of the degree of inflammation and fibrosis were compared with the actual liver biopsy using an adaptation of a standard histological scoring system. We studied 81 adults with previously untreated
      chronic hepatitis C, raised serum transaminases and positive HCV-RNA in serum. Clinicians predicted the inflammatory grade in 44 of 80 cases (55%) and the fibrosis stage in 46 of 81 cases (57%). Nine of 17 cirrhotic cases were predicted (sensitivity 53%, specificity 56%). No unexpected additional diagnoses were made on the biopsies. Thus despite knowledge of the clinical and laboratory investigations of patients with hepatitis C, clinicians are unable to accurately predict the hepatic inflammatory grade and fibrotic stage. Liver biopsy is an essential investigation to accurately evaluate the grade and stage of liver disease patients with hepatitis C.




      [Non-text portions of this message have been removed]
    Your message has been successfully submitted and would be delivered to recipients shortly.