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Re: [GIWorld-Hepatitis] Serzone & its generics can damage liver

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  • Tatezi
    My mother takes prozac and has for abou 8 years...she s never mentioned to me that she could no longer get it. Why was zoloft taken off the market... ... From:
    Message 1 of 13 , May 22 8:12 AM
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      My mother takes prozac and has for abou 8 years...she's never mentioned to me that she could no longer get it.

      Why was zoloft taken off the market...

      ----- Original Message -----
      From: AVansi7465@...
      To: GIWorld-Hepatitis@yahoogroups.com
      Sent: Friday, May 21, 2004 3:40 PM
      Subject: Re: [GIWorld-Hepatitis] Serzone & its generics can damage liver


      I thought that Zoloft had been taken off the market along
      with Prozac......



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    • AVansi7465@aol.com
      In a message dated 5/21/2004 5:58:45 PM Eastern Daylight Time, alleypat@comcast.net writes: However, Seratonin Reuptake Inhibitors act the opposite on me.
      Message 2 of 13 , May 22 5:53 PM
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        In a message dated 5/21/2004 5:58:45 PM Eastern Daylight Time,
        alleypat@... writes:
        However, Seratonin Reuptake Inhibitors act the opposite on me. Instead of
        fixing depression they make me depressed. Go figure. I'm like that with a lot of
        meds. Bassackwards oy!
        That's probably why I've always thought Anti d's were not one of our more
        useful pharmalogical accomplishments.


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      • Patricia (Alley)
        Prozac and Zoloft have not been taken off the market. Alley [Non-text portions of this message have been removed]
        Message 3 of 13 , May 22 5:56 PM
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          Prozac and Zoloft have not been taken off the market.

          Alley

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        • AVansi7465@aol.com
          In a message dated 5/22/2004 11:08:57 AM Eastern Daylight Time, tatezi@sbcglobal.net writes: When western medicine comes across something they don t
          Message 4 of 13 , May 23 11:15 AM
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            In a message dated 5/22/2004 11:08:57 AM Eastern Daylight Time,
            tatezi@... writes:
            When western medicine comes across something they don't understand, they
            start prescribing chemicals...it's the western world way.
            Much to my dismay, that statement is, at least, true for some doctors, not
            all. Anne


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          • AVansi7465@aol.com
            In a message dated 5/22/2004 11:46:54 AM Eastern Daylight Time, tatezi@sbcglobal.net writes: My mother takes prozac and has for abou 8 years...she s never
            Message 5 of 13 , May 23 11:22 AM
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              In a message dated 5/22/2004 11:46:54 AM Eastern Daylight Time,
              tatezi@... writes:
              My mother takes prozac and has for abou 8 years...she's never mentioned to me
              that she could no longer get it.

              Why was zoloft taken off the market...
              My goof. Zoloft was taken off for awhile, reworked and brought back with a
              slightly different formula. I thought that prozac went bye bye permanently,
              but my info isn't up to date on anti depressents.


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            • jtwagers7@aol.com
              Hi all. Hope everyone is feeling OK!! This Anti D topic really hits home for me. When a patient is depressed (regardless the etiology) it is sometimes
              Message 6 of 13 , May 26 3:48 PM
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                Hi all. Hope everyone is feeling OK!! This Anti D topic really hits home
                for me.

                When a patient is depressed (regardless the etiology) it is sometimes very
                difficult for the patient / doctor to differentiate between side effects of
                the Anti D's (some unpleasant) and signs of worsening depression. I think
                this holds particularly true for the HCV patient since symptoms of HCV can
                include chronic fatigue, insomnia, and mental status changes.

                All Anti'd's (since all can cause worsening depression in some patients)
                carry the risk of increased suicidal ideation. Some HCV patients don't metabolize
                drugs due to an impaired liver. This can lead to toxicity. Toxicity can
                make the side effects of the drug more pronounced (not to mention it can damage
                the liver).

                Side effects from Anti D's, SSRI-intolerance, risk of toxicity, withdrawal
                syndrome, etc., are frequently (unfortunately) not discussed with the patient
                prior to beginning therapy with antidepressants. Many psychiatrists push one
                antidepressant after the next to treat "symptoms". It's the standard to try,
                try, and try again. I think, overall, that is good practice because it does
                improve -- in my cases -- the patient's quality of life when an antidepressant
                is found to treat the symptoms effectively and safely.

                Frequently, though, only one antidepressant works effectively in a clinically
                depressed patient. Serzone, for example, may be the only antidepressant that
                improves the patient's symptoms, but the use of this antidepressant has been
                linked to liver failure. Even though the HCV patient's depression may improve
                on this drug, the patient is at risk of liver failiure (and death) if they
                continue taking it.

                If someone being treated for depression is not responding favorably or begins
                to feel worse, I think it's healthy to consider alternatives -- one of which
                is to keep trying different AntiD's. Another is to consider stopping them
                (under the care of a psychiatrist) and see if you feel better. My psychiatrist
                was not pleased with my decision to stop attempting Anti D's, but I was
                adamant I wasn't taking another one. Off the AntiD's, I still felt tired, I still
                had insomnia, I still had to take naps everyday, but I wasn't as "zonked out"
                feeling.

                When I was diagnosed HCV, I had been off all AntiD's for about a year. My GI
                doc strongly recommended that I get back on an AntiD, and he recommended the
                new "liver friendly" SSRI called Lexapro, termed "liver friendly" by the
                manufacturer (and therefore frequently prescribed by GI docs to newly diagnosed
                HCV patients). I agreed to give it a try. During the first few days, my
                energy was much increased (I felt like I was doing speed, which was OK because at
                least I had some energy). I was very pleased (even enthusiastic) that this
                new AntiD seemed to be working. My enthusiasm was short-lived, though.
                During the second week on this SSRI, I began to feel like I couldn't raise my
                head. I did nothing but lay on the couch when I wasn't in the bed, and whether in
                bed or on the couch, I had vivid nightmares (I could not escape the
                nightmares). I was horizontal 14 to 16 hours out of the day -- everyday. I felt
                worse than tranquilized and thought I had hepatic encephalopathy. Both my
                shrink and GI doc reassured me I did not have hepatic encephalopathy, and they
                advised cutting the dose from 10 mg per day to 5 mg per day. I saw no reason
                whatsoever to continue this drug Anti D -- even at a reduced dose -- and I stopped
                it altogether. That was a huge no-no on my part. Even though I felt better
                almost immediately (began to have some energy back) I began to have strange
                sensations all over my body, as if someone was shocking me. "Brain buzzes"
                is what this sensation is affectionately termed (SSRI withdrawal is the
                syndrome it's been named). I knew nothing about SSRI withdrawal syndrome. This
                syndrome came about because reports to the drug manufacturer that some patient's
                on SSRIs were complaining of having strange electric shock sensations. I had
                complained of this sensation in June 2000, and sure enough -- it was found
                noted in my chart "patient believes she has multiple sclerosis". (The reason I
                thought I had MS was because I was so depressed for so long, I had dramatic
                mental status changes going on, I wasn't getting any better on any antiD, and I
                had begun to note strange sensations shooting through my body -- especially
                my face). I kept telling my shrink "something is seriously wrong with me -- I
                have something more than depression". I did. I had HCV, undiagnosed, the
                entire time while being treated for depression. My CBCs, LFTs, and enzymes
                were always within normal limits, and liver disease was therefore not suspected
                -- even though it was well documented that I had Hep NonA NonB in the 70's
                from IV drug abuse.

                I get pretty angry today when I look back from 1998 to 2002 and recall how
                much I was complaining to the docs "something is seriously wrong with me" and
                how the docs acted like I was hysterical or a hypochondriac (not much
                difference in the two). Even I began to believe I was a hypochondriac and hysterical.
                I had all the signs of being a hysterical, perhaps premenopausal female -
                LOL! Strange rashes, hives, itching, sweating, insomnia, and "buzzy"
                sensations.

                Anyhow... after the experience with Lexapro, I was deemed SSRI intolerant. I
                was no doubt SSRI intolerant the entire time while being treated for chronic
                depression with SSRI's for many years. It was agreed last year by my shrink
                and GI doc that since I had never responded favorably to Anti D's, I would
                probably never respond favorably to them. SSRIs are now considered
                contraindicated in me.

                Many people cannot tolerate SSRIs. If you're ever placed on one and react
                badly, advise you doctor. If you're ever told you cannot tolerate SSRI's, do
                not ever take them again because you will only respond the same way (or worse)
                to another one. Don't EVER stop an SSRI suddenly.

                I've been off Anti D's for over a year now, and I feel 100% improved (no more
                fatigue, no more insomnia, no more exhaustion, no more night sweats, no more
                withdrawal syndrome). If I didn't know I had HCV, I wouldn't know it.

                If I feel better not taking antiD's, then maybe someone else who's got HCV
                and has felt awful while on antidepressants may begin to feel better if they
                stop taking them, too. Chronic depression is an awful thing to live with.

                I hope everyone out there who is suffering from depression (regardless the
                etiology) finds something that works for them. BUT ( BIG BUT ) please
                don't take Serzone to treat your depression. If you've to HCV, you should be
                very concerned about how antiD's might affect your liver. While it's important
                to combat depression and fatigue, it's not always possible to do so when one is
                symptomatic with HCV. If you've got HCV, it's more important and more
                healthy to avoid hepatotoxic substances and learn to live with the fatigue.

                If your doctor (specialist, GP, shrink, GI doc, neuro doc) acts like they
                don't want to hear you out or attempt something else or attempt something you
                think might help you feel better, put your foot down and take some control back
                into your own hands. It's your life. Depression and chronic fatigue are
                awful things to live with, but you CAN live with it. Serzone is an
                antidepressant that could kill you. Other antidepressants can also cause liver damage.
                There is not always a cure through medicine. Be careful.

                Julie



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