Loading ...
Sorry, an error occurred while loading the content.

Study Shows Highest Sustained Response Rates Ever Reported in Patients Infected with Hepatitis C

Expand Messages
  • claudine intexas
    Hi all, Please note that this is a NEWS report, and as usual with most news reports, they managed to get some facts screwed up! C Study Shows Highest Sustained
    Message 1 of 1 , Mar 2 5:53 PM
    • 0 Attachment
      Hi all,
      Please note that this is a NEWS report, and as usual with most
      news reports, they managed to get some facts screwed up!
      C


      Study Shows Highest Sustained Response Rates Ever Reported in
      Patients Infected with Hepatitis C


      - Combination of Pegasys(R) and Copegus(R) Yields Response in

      Over 60 Percent of Patients -

      LA JOLLA, Calif., March 2 /PRNewswire/ -- A landmark study
      examining the efficacy and safety of the drug combination
      Pegasys(R) (peginterferon alfa-2a), a pegylated interferon, with
      Copegus(R) (ribavirin), an antiviral medication, has found the most
      significant response rates ever achieved in patients infected with
      hepatitis C, according to Paul Pockros, M.D., at Scripps Clinic.
      The combination treatment yielded a 61 percent sustained virologic
      response (SVR), the highest SVR ever reported in a clinical trial
      for a pegylated interferon.

      SVR refers to a patient's continued undetectable serum hepatitis C
      (HCV) RNA levels six months after discontinuation of treatment.
      The results of the study were published in this week's Annals of
      Internal Medicine.

      Hepatitis C is a blood-borne virus that attacks the liver, causing
      cirrhosis (liver scarring) and liver cancer, and is the primary
      reason many patients undergo liver transplants in the U.S. An
      estimated 4 million Americans are infected with hepatitis C, with
      2.7 million chronically infected.

      "The outcome of this study provides critical insights for treating
      the 35,000 people being diagnosed each year with hepatitis C,"
      explained Pockros, a U.S. investigator in the trial and head of the
      division of gastroenterology and hepatology at Scripps Clinic in La
      Jolla, Calif. "Most notably, we can now say that the virus can be
      cured in more than half of the patients treated."

      The study also revealed clinical evidence that, to achieve optimal
      results, treatment duration should be based on hepatitis C virus
      genotype, rather than on the traditional, weight-based methodology.

      Additionally, the study found a 51 percent SVR, the highest ever
      achieved, for patients with genotype 1, the most difficult to treat
      and most prevalent genotype. The study also confirms that these
      patients require a year of treatment (48 weeks) with Pegasys and
      the standard dose of ribavirin (daily 1000mg/1200mg) in order to
      achieve the optimal outcome. The success rate was even higher for
      genotype non-1 patients, with 78 percent achieving an SVR after
      only 24 weeks of therapy and a low daily 800mg dose of ribavirin.

      "This is the first study to confirm that for certain patients, we
      can use a lower dose of therapy and cut the treatment duration by
      half without sacrificing efficacy. Potentially, this can save some
      patients nearly six months of unnecessary treatment," said Pockros.

      In addition to Scripps Clinic, the randomized, multi-center study
      had a total of 99 sites around the world and included 1,284
      patients stratified by genotype into one of four treatment groups:

      * PEGASYS 180 ug qw + ribavirin 800 mg qd for 24 weeks

      * PEGASYS 180 ug qw + ribavirin 1000-1200 mg qd for 24 weeks

      * PEGASYS 180 ug qw + ribavirin 800 mg qd for 48 weeks

      * PEGASYS 180 ug qw + ribavirin 1000-1200 mg qd for 48 weeks

      In this study, the adverse events were similar to previous reported
      trials and included flu-like symptoms, fatigue and depression.

      Founded in 1924, Scripps Clinic is a multi-specialty, outpatient
      care facility caring for patients at multiple locations throughout
      San Diego County. Scripps Clinic and its physicians are
      world-renown for research- driven care and medical specialty
      expertise and is an operating unit of Scripps Health, a
      not-for-profit, community-based health care delivery network that
      includes more than 2,600 affiliated physicians, five acute-care
      hospitals, home health care and associated support services.
      Scripps Health is one of the largest health care organizations in
      San Diego County, drawing from the expertise of more than 10,000
      health care professionals.

      SOURCE Scripps Clinic


      __________________________________
      Do you Yahoo!?
      Yahoo! Search - Find what you�re looking for faster
      http://search.yahoo.com
    Your message has been successfully submitted and would be delivered to recipients shortly.