inf/riba after malignant hematoncology
- (now my curiousity is aroused and I'm looking for instances of using riba after malignant cancers and which ones etc. I'll share what I find. tho I may not understand what I find lol. .. Alley)
Interferon plus ribavirin may benefit pediatric cancer survivors with
5th October, 2000
Pediatrics 2000;106:e53 -
WESTPORT, CT (Reuters Health) - Results of a pilot study suggest that, like
adults infected with hepatitis C virus (HCV), children with chronic HCV
infection after cure of malignancy may benefit from combination therapy with
recombinant interferon-alpha (IFN-alpha) and ribavirin. Dr. Herwig Lackner
and a team from Karl-Franzens-University, Graz, Austria, report the finding
in the October Pediatrics electronic pages.
Dr. Lackner and colleagues treated 12 such children with recombinant
IFN-alpha and ribavirin for 12 months, using a regimen similar to that often
used in adults. The children had ranged in age from 0.1 to 14.7 years at the
time of diagnosis of the underlying disease.
The investigators report that half of the patients achieved a sustained
response, defined as undetectable HCV RNA levels for more than 1 year after
completion of combination therapy. "This response rate is of note," the
authors write, "because all patients were survivors of previous malignant
hematooncologic diseases and all patients had HCV genotype 1, factors
usually predicting a poor response to IFN treatment."
Treatment-related side effects were "moderate and reversible," according to
the authors. All patients experienced a decrease in blood counts and all
developed flu-like symptoms. In three of the 12 patients the interferon dose
had to be lowered by 10%.
Dr. Lackner and colleagues say that the results are "encouraging" and should
prompt further study. But it is noteworthy, they point out, that 50% of
patients did not respond to combination IFN-alpha/ ribavirin therapy.
"Whether these patients will respond to higher doses or longer courses of
treatment or new antiviral drug combinations needs to be investigated."
Sheree Martin mailto:martins@...
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Hep B Archives: http://dispatch.mail-list.com/archives/hbv_research/
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