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HCV Infection Rate Seems Low in At-Risk Women

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  • claudine intexas
    HCV Infection Rate Seems Low in At-Risk Women By Megan Rauscher NEW YORK (Reuters Health) Dec 03 - New data from the Women s Interagency HIV Study (WIHS)
    Message 1 of 2 , Dec 10, 2003
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      HCV Infection Rate Seems Low in At-Risk Women

      By Megan Rauscher

      NEW YORK (Reuters Health) Dec 03 - New data from the Women's
      Interagency HIV Study (WIHS) suggest that the incidence of hepatitis
      C virus (HCV) infection is low among women with, or at risk for,
      HIV-1 infection. The data also suggest that HCV is now almost
      exclusively linked to drug use, and often resolves.

      Dr. Michael Augenbraun from the State University of New
      York-Downstate Medical Center in Brooklyn and the multicenter WIHS
      team retrospectively screened 1517 stored serum samples for HCV
      antibody and viremia from a group of initially HIV-infected,
      HCV-uninfected women and from HIV-uninfected, HCV-uninfected women.

      "These women were being followed prospectively as part of a large
      study of the natural history of HIV infection in women," Dr.
      Augenbraun told Reuters Health. "The point was to try to find women
      not infected with HCV who subsequently developed infection."

      Not many of them did, the researcher said. Over a 3- to 4-year
      period, only 22 (1.5%) of 1517 exhibited HCV seroconversion. Of
      these, only 14 truly acquired HCV as determined by enzyme immunoassay
      and new-onset viremia. Dr. Augenbraun admitted that he was "surprised
      that so few women" acquired HCV infection.

      The HCV incidence rate in HIV-infected and HIV-uninfected women was
      2.7 and 3.3 cases per 1000 person-years, respectively. "Not
      surprisingly," Dr. Augenbraun said, "most of the women that acquired
      HCV had a history of drug use."

      He also noted that in several HIV/HCV-coinfected women, "the
      appearance of HCV antibody took many months to years after the
      appearance of virus in the serum."

      Moreover, "a large portion of HCV-infected women (42%) appeared to
      durably clear HCV from their serum, a percentage considerably in
      excess of current estimates," Dr. Augenbraun pointed out.

      Writing in the November 15th issue of Clinical Infectious Diseases,
      the researchers suggest that clinicians "maintain a high index of
      suspicion of HCV infection for individuals at risk and consider
      repeated antibody testing, as well as HCV RNA testing, when such
      individuals have negative results of a single antibody study."

      Clin Infect Dis 2003;37:1357-1364.


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    • AVansi7465@aol.com
      Drug Use !?!?!?!?!?!? What a crock!!!!!!!!!!!!!! [Non-text portions of this message have been removed]
      Message 2 of 2 , Jan 6, 2004
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        "Drug Use"!?!?!?!?!?!? What a crock!!!!!!!!!!!!!!


        [Non-text portions of this message have been removed]
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