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High Dose Peginterferon for Non-responders, and Naïve & Relapsers

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  • claudine intexas
    NATAP - www.natap.org Jules Levin High Dose Peginterferon for Non-responders, and Naïve & Relapsers To read the three studies mentioned in the following
    Message 1 of 1 , Oct 31, 2003
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      NATAP - www.natap.org

      Jules Levin

      High Dose Peginterferon for Non-responders, and Na�ve & Relapsers
      To read the three studies mentioned in the following article go to:
      http://www.natap.org/2003/AASLD/day5_1.htm

      This article contains a comprehensive review with tables of 3 studies
      resented at AASLD, whicv examine using high dose peginterferon in
      combination with ribavirin for patients who are previous
      non-responders to IFN/RBV. As well, one study examines high dose in
      treatment-naives. I think you'll see from the preliminary study data
      that it appears as if high dose peginterferon can increase viral
      clearance in IFN/RBV nonresponders compared to standard doses of
      PEG/RBV. But the problem may be tolerability. The Pegasys high dose
      study results are early data but show better viral responses with
      high dose Pegasys. The PegIntron data reports week 24, 48, and 72
      week preliminary data and supports better viral clearance, but
      tolerability concerns after week 24. For previous nonresponders to
      IFN/RBV using the higher Peginterferon dose in combination with RBV
      preliminarily appears to be a feasible strategy based on the data we
      have so far that suggests higher dosing might yield to improved viral
      response rates compared to using standard Peginterferon dose if you
      can tolerate the higher doses. Waiting for final study results will
      provide more comprehensive information for making treatment decisions
      for nonresponders.


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