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Hepatitis C Virus, B-cell Proliferation and Lymphomas

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    Leukemia and Lymphoma Publisher: Taylor & Francis Health Sciences, part of the Taylor & Francis Group Issue: Volume 43, Number 4/2002 Pages: 747 - 751
    Message 1 of 1 , Aug 31, 2003
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      Leukemia and Lymphoma
      Publisher: Taylor & Francis Health Sciences, part of the Taylor &
      Francis Group
      Issue: Volume 43, Number 4/2002
      Pages: 747 - 751


      Hepatitis C Virus, B-cell Proliferation and Lymphomas

      Daniela Gasparotto, Valli De Re, Mauro Boiocchi

      Division of Experimental Oncology 1, Centro di Riferimento
      Oncologico, via Pedemontana Occidentale 12, 33081 Aviano (PN), Italy


      Abstract:


      Accumulating evidence support a role for hepatitis C virus (HCV) in
      the pathogenesis of human lymphoproliferative disorders. Clonal
      expansions of B lymphocytes have been prevalently detected in the
      bone marrow, in the liver and in the peripheral blood of HCV-infected
      patients. Epidemiologic studies have associated HCV infection with an
      increased risk of B-cell lymphoma development, particularly of those
      with primary localization to organs target of HCV infection.

      The analysis of the B-cell receptor variable region sequences in
      sequential phases of HCV-associated lymphomas provided evidence of an
      ongoing somatic mutation process still present in the neoplastic
      cells. A restricted repertoire of V, D, J genes was used to assemble
      the B-cell receptor, and a frequent occurrence of certain gene
      combinations (V1-69/D3-22/J4 heavy chain with a V3-20 encoded light
      chain; V3-7/D3/J3 heavy chain with V3-15/J1 light chain;
      V3-23/D3-22/J4 or V4-59/D2-15/J2 with a V3-20 light chain) was
      observed, thus suggesting a common antigen-binding specificity for
      these B-cell clones. The high similarity to antibodies with
      rheumatoid factor (RF) activity as well as to anti-HCV E2 antibodies
      suggested that HCV, alone or in complex with IgG, could play a
      pathogenetic role as an exogenous trigger in certain stages of B-cell
      lymphoproliferation and in certain subsets of B-cell non-Hodgkin's
      lymphomas (NHLs). The restricted gene repertoire used to assemble the
      B-cell receptor observed in HCV-associated B-cell NHLs could have
      important implications as an antigenic target in anti-tumor
      immunologic therapies.


      References:

      1.Choo, Q., Weiner, A.J., Overby, L.R., Kuo, G., Houghton, M. and
      Bradley, D.W. (1990) "Hepatitis C virus: the major causative agent of
      viral non-A, non-B hepatitis", Br. Med Bull. 46, 423 - 441

      2.Alter, H.J. (1995) "To C or not to C: these are the questions",
      Blood 85, 1681 - 1695

      3.Ferri, C., La Civita, L., Longobardo, G., Zignego, A.L. and Pasero,
      G. (1998) "Mixed cryoglobulinaemia: a cross-road between autoimmune
      and lymphoproliferative disorders", Lupus 7, 275 - 279

      4.Perl, A., Gorevic, P.D., Ryan, D.H., Condemi, J.J., Ruszkowski,
      R.J. and Abraham, G.N. (1989) "Clonal B cell expansions in patients
      with essential mixed cryoglobulinaemia", Clin. Exp. Immunol. 76, 54 -
      60

      5.Meroni, P.L., Barcellini, W., Sinico, R.A., Fornasieri, A.,
      Sguotti, C., Invernizzi, F., D'Amico, G. and Zanussi, C. (1986) "In
      vitro synthesis of IgM rheumatoid factor by lymphocytes from patients
      with essential mixed cryoglobulinemia", Clin. Exp. Immunol. 65, 303 -
      310

      6.Curry, M.P., Golden-Mason, L., Nolan, N., Parfrey, N.A., Hegarty,
      J.E. and O'Farrelly, C. (2000) "Expansion of peripheral blood CDS+ B
      cells is associated with mild disease in chronic hepatitis C virus
      infection", J. Hepatol. 32, 121 - 125

      7.De Re, V., De Vita, S., Marzotto, A., Gloghini, A., Pivetta, B.,
      Gasparotto, D., Cannizzaro, R., Carbone, A. and Boiocchi, M. (2000)
      "Pre-malignant and malignant lymphoproliferations in an HCV-infected
      type II mixed cryoglobulinemic patient are sequential phases of an
      antigen-driven pathological process", Int. J. Cancer 87, 211 - 216

      8.Franzin, F., Efremov, D.G., Pozzato, G., Tulissi, P., Batista, F.
      and Burrone, O.R. (1995) "Clonal B-cell expansions in peripheral
      blood of HCV-infected patients", Br. J. Haematol. 90, 548 - 552

      9.Santini, G.F., Crovatto, M., Giannini, F., Bortolin, M.T., Mazzaro,
      C. and Invernizzi, F. (1998) "Hepatitis C virus and immunoglobulin
      gene rearrangements: an early step in lymphomagenesis?", Acta
      Haematol. 100, 117 - 122

      10.Mosnier, J.F., Degott, C., Marcellin, P., Henin, D., Erlinger, S.
      and Benhamou, J.P. (1993) "The intraportal lymphoid nodule and its
      environment in chronic hepatitis C: an immunohistochemical study",
      Hepatology 17, 366 - 371

      11.Monteverde, A., Ballar�, M. and Pileri, S. (1997) "Hepatitic
      lymphoid aggregates in chronic hepatitis C and mixed
      cryoglobulinemia", Springer Semin. Immunopathol. 19, 99 - 110

      12.Murakami, J., Shimizu, Y., Kashii, Y., Kato, T., Minemura, M.,
      Okada, K., Nambu, S., Takahara, T., Higuchi, K., Maeda, Y., Kumada,
      T. and Watanabe, A. (1999) "Functional B-cell response in
      intrahepatic lymphoid follicles in chronic hepatitis C", Hepatology
      30, 143 - 150

      13.Sansonno, D., De Vita, S., Iacobelli, A.R., Cornacchiulo, V.,
      Boiocchi, M. and Dammacco, F. (1998) "Clonal analysis of intrahepatic
      B cells from HCV-infected patients with and without mixed
      cryoglobulinemia", J. Immunol. 160, 3594 - 3601

      14.Magalini, A.R., Facchetti, F., Salvi, L., Fontana, L., Puoti, M.
      and Scarpa, A. (1998) "Clonality of B-cells in portal lymphoid
      infiltrates of HCV-infected livers", J. Pathol. 185, 86 - 90

      15.Racanelli, V., Sansonno, D., Piccoli, C., D'Amore, F.P., Tucci,
      F.A. and Dammacco, F. (2001) "Molecular characterization of B cell
      clonal expansions in the liver of chronically hepatitis C
      virus-infected patients", J. Immunol. 167, 21 - 29

      16.Monteverde, A., Sabattini, E., Poggi, S., Ballar�, M.,
      Bertoncelli, M.C., De Vivo, A., Briskomatis, A., Roncador, G.,
      Falini, B. and Pileri, S. (1995) "Bone marrow findings further
      support the hypothesis that essential mixed cryoglobulinemia type II
      is characterized by a monoclonal B-cell proliferation", Leuk. Lymph.
      20, 119 - 124

      17. Rasul, I., Sheperd, F.A., Kamel-Reid, S., Krajden, M., Pantalony,
      D. and Heathcote, E.J. (1999) "Detection of occult low-grade B-cell
      non-Hodgkin's lymphoma in patients with chronic hepatitis C infection
      and mixed cryoglobulinemia", Hepatology 29, 543 - 547

      18. De Vita, S., De Re, V., Gasparotto, D., Ballar�, M., Pivetta, B.,
      Ferraccioli, G., Pileri, S., Boiocchi, M. and Monteverde, A. (2000)
      "Oligoclonal non-neoplastic B-cell expansion is the key feature of
      type II mixed cryoglobulinemia", Arthritis Rheum. 43, 94 - 102

      19.Silvestri, F. and Baccarani, M. (1997) "Hepatitis C virus-related
      lymphomas", Br. J. Haematol. 99, 475 - 480

      20.Luppi, M., Ferrari, M.G., Bonaccorsi, G., Longo, G., Narni, F.,
      Barozzi, P., Marasca, R., Mussini, C. and Torelli, G. (1996)
      "Hepatitis C virus infection in subsets of neoplastic
      lymphoproliferations not associated with cryoglobulinemia", Leukemia
      10, 351 - 355

      21.Silvestri, F., Pipan, C., Barillari, G., Zaja, F., Fanin, R.,
      Infanti, L., Russo, D., Falasca, E., Botta, G.A. and Baccarani, M.
      (1996) "Prevalence of hepatitis C virus infection in patients with
      lymphoproliferative disorders", Blood 87, 4296 - 4301

      22. Di Stasi, M., Sbolli, G., Fornari, F., Cavanna, L., Rossi, S.,
      Buscarini, E., Civerdi, G., Vallisa, D., Berte, R. and Buscarini, L.
      (1994) "Extrahepatic primary malignant neoplasms associated with
      hepatocellular carcinoma: high occurrence of B cell tumors", Oncology
      51, 459 - 464

      23.Lombardo, L., Rota Scalabrini, D., Vineis, P. and De la Pierre, M.
      (1993) "Malignant lymphoproliferative disorders in liver cirrhosis",
      Ann. Oncol. 4, 245 - 250

      24.De Vita, S., Sacco, C., Sansonno, D., Gloghini, A., Dammacco, F.,
      Crovatto, M., Santini, G., Dolcetti, R., Boiocchi, M., Carbone, A.
      and Zagonel, V. (1997) "Characterisation of overt B-cell lymphomas in
      patients with hepatitis C virus infection", Blood 90, 776 - 782


      25. De Vita, S., Zagonel, V., Russo, A., Rupolo, M., Cannizzario, R.,
      Chiara, G., Boiocchi, M., Carbone, A. and Franceschi, S. (1998)
      "Hepatitis C virus, non-Hodgkin's lymphomas and hepatocellular
      carcinoma", Br. J. Cancer 77, 2032 - 2035

      26.De Vita, S., Sansonno, D., Dolcetti, R., Ferraccioli, G., Carbone,
      A., Cornacchiulo, V., Santini, G., Crovatto, M., Gloghini, A.,
      Dammacco, F. and Boiocchi, M. (1995) "Hepatitis C virus within a
      malignant lymphoma lesion in the course of type II mixed
      cryoglobulinemia", Blood 86, 1887 - 1892

      27.Sansonno, D., De Vita, S., Cornacchiulo, V., Carbone, A.,
      Boiocchi, M. and Dammacco, F. (1996) "Detection and distribution of
      hepatitis C-related proteins in lymph nodes of patients with type II
      mixed cryoglobulinemia and neoplastic or non-neoplastic
      lymphoproliferation", Blood 88, 4638 - 4645

      28.De Vita, S., De Re, V., Sansonno, D., Sorrentino, D., La Corte,
      R., Pivetta, B., Gasparotto, D., Racanelli, V., Marzotto, A.,
      Labombarda, A., Gloghini, A., Ferraccioli, G., Monteverde, A.,
      Carbone, A., Dammacco, F. and Boiocchi, M. (2000) "Gastric mucosa as
      an additional extrahepatic localization of hepatitis C virus: viral
      detection in gastric low-grade lymphoma associated with autoimmune
      disease and in chronic gastritis", Hepatology 31, 182 - 189

      29.Agnello, V. (1995) "The aetiology of mixed cryoglobulinaemia
      associated with hepatitis C virus infection", Scand. J. Immunol. 42,
      179 - 184

      30.Agnello, V. (1997) "Hepatitis C virus infection and type II
      cryoglobulinemia: an immunological perspective", Hepatology 26, 1375
      - 1379

      31.Martin, T., Duffy, S.F., Carson, D.A. and Kipps, T.J. (1992)
      "Evidence for somatic selection of natural autoantibodies", J. Exp.
      Med. 175, 983 - 991

      32.Martin, T., Crouzier, R., Weber, J.-C., Kipps, T.J. and Pasquali,
      J.L. (1994) "Structure-function studies on a polyreactive (Natural)
      autoantibody. Polyreactivity is dependent on somatically generated
      sequences in the third complementarity-determining region of the
      antibody heavy chain", J. Immunol. 152, 5988 - 5996

      33.De Re, V., De Vita, S., Marzotto, A., Rupolo, M., Gloghini, A.,
      Pivetta, B., Gasparotto, D., Carbone, A. and Boiocchi, M. (2000)
      "Sequence analysis of the immunoglobulin antigen receptor of
      hepatitis C virus-associated non-Hodgkin lymphomas suggests that the
      malignant cells are derived from the rheumatoid factor-producing
      cells that occur mainly in type II cyoglobulinemia", Blood 96, 3578 -
      3584

      34.Ivanovski, M., Silvestri, F., Pozzato, G., Anand, S., Mazzaro, C.,
      Burrone, O.R. and Efremov, D.G. (1998) "Somatic hypermutation, clonal
      diversity, and preferential expression of the VH 51pl/VL kv325
      immunoglobulin gene combination in hepatitis C virus-associated
      immunocytomas", Blood 91, 2433 - 2442

      35.Marasca, R., Vaccari, P., Luppi, M., Zucchini, P., Castelli, I.,
      Barozzi, P., Cuoghi, A. and Torelli, G. (2001) "Immunoglobulin gene
      mutations and frequent use of VH1-69 and VH4-34 segments in hepatitis
      C virus-positive and hepatitis C virus-negative nodal marginal zone
      B-cell lymphoma", Am. J. Pathol. 159, 253 - 261

      36.Gorevic, P.D. and Frangione, B. (1991) "Mixed cryoglobulinemia
      cross-reactive idiotypes: implications for the relationship of MC to
      rheumatic and lymphoproliferative diseases", Semin. Hematol. 28, 79 -
      94

      37. Knight, G.B., Agnello, V., Bonagura, V., Barnes, J.L., Panka,
      D.J. and Zhang, Q.X. (1993) "Human rheumatoid factor cross-idiotypes.
      IV. Studies on WA XId-positive IgM without rheumatoid factor activity
      provide evidence that the WA XId is not unique to rheumatoid factors
      and is distinct from the 17.109 and G6 XIds", J. Exp. Med. 178, 1903
      - 1911

      38.B�rretzen, M., Randen, I., �d�rsk�, E., F�rre, �., Natvig, J.B.
      and Thompson, K.M. (1994) "Control of autoantibody affinity by
      selection against amino acid replacements in the
      complementarity-determining regions", Proc. Natl Acad. Sci. USA 91,
      12917 - 12921

      39.Hubert Chan, C., Handlock, K.G., Foung, S.K. and Levy, S. (2001)
      "VH1-69 gene is preferentially used by hepatitis C virus-associated B
      cell lymphomas and by normal B cells responding to the E2 viral
      antigen", Blood 97, 1023 - 1026

      40.Sutton, B.J., Corper, A.L., Sohi, M.K., Jefferis, R., Beale, D.
      and Taussig, M.J. (1998) "The structure of a human rheumatoid factor
      bound to IgG Fc", Adv. Exp. Med. Biol. 435, 41 - 50

      41.Treon, S.P., Raje, N. and Anderson, K.C. (2000) "Immunotherapeutic
      strategies for the treatment of plasma cell malignancies", Semin.
      Oncol. 27, 598 - 613



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