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Zinc plays an important role in the maintenance of immune function

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  • claudine intexas
    http://www.lef.org/protocols/abstracts/4 Reinhold D.; Ansorge S.; Grungreiff K. Dr. K. Grungreiff, Heydeckstr. 9, D-39104 Magdeburg Germany Journal of Trace
    Message 1 of 1 , Aug 3, 2003
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      http://www.lef.org/protocols/abstracts/4

      Reinhold D.; Ansorge S.; Grungreiff K.
      Dr. K. Grungreiff, Heydeckstr. 9, D-39104 Magdeburg Germany
      Journal of Trace Elements in Experimental Medicine (USA), 1997, 10/1
      (19-27)

      Zinc (zinc ions and/or chelated zinc) plays an important role in the
      maintenance of immune function. Patients with chronic liver disease,
      particularly liver cirrhosis, frequently have endotoxemia, increased
      serum concentrations of cytokines, e.g., interleukin-6 (IL-6), and
      reduced serum zinc levels. The aim of the present study was to
      investigate the effects of zinc (ZnCl2, ZnO, ZnSO4) on DNA synthesis
      and cytokine production (IL-2, IL-6, IL-10) in pokeweed mitogen
      (PWM)-stimulated peripheral blood mononuclear cells (PBMC). In
      addition, we examined the effect of long-term zinc supplementation
      (zinc-hydrogen-aspartate; UNIZINK 50; 3 x 1 = 29.76 mg/day) on IL-6
      and IL-10 serum levels in patients with chronic liver disease (n =
      16), all with reduced serum zinc levels. It could be shown that zinc
      concentrations up to 0.1 mM stimulate DNA synthesis and cytokine
      production by PWM-stimulated PBMC, whereas higher concentrations
      (0.2-0.4 mM) have a strongly inhibitory effect. Zinc concentrations
      exceeding 0.5 mM were found to have a toxic effect on these immune
      cells. Interestingly, in most patients with chronic liver disease (n
      = 10), zinc supplementation decreased IL-6, and to a lesser extent,
      IL-10 serum levels, and normalized the serum zinc concentrations. We
      conclude that zinc plays a regulatory role in DNA synthesis and
      cytokine production by PBMC. The critical zinc concentration for
      immune cells lies in the range of 0.5 mM, which is equivalent to a
      daily dose of similar45 mg zinc salt. Furthermore, zinc
      supplementation in chronic liver disease with reduced serum zinc
      levels appears to normalize IL-6 and IL-10 production.


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