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Oxidative stress in chronic hepatitis C: not just a feature of late

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  • claudine intexas
    Journal of Hepatology, Vol. 36 (6) (2002) pp. 805-811 © 2002 European Association for the Study of the Liver. Published by Elsevier Science B.V. All rights
    Message 1 of 1 , Aug 3, 2003
      Journal of Hepatology, Vol. 36 (6) (2002) pp. 805-811

      � 2002 European Association for the Study of the Liver. Published by
      Elsevier Science B.V. All rights reserved.
      PII: S0168-8278(02)00060-0

      Oxidative stress in chronic hepatitis C: not just a feature of late
      stage disease

      Sanjiv K. Jain 1, Philip W. Pemberton 1, Alexander Smith 1, Raymond
      F.T. McMahon 2, Peter C. Burrows 1, Ali Aboutwerat 1 and Thomas W.
      Warnes 1 * twwarnes@...
      1 The Liver Unit, Manchester Royal Infirmary, Manchester, UK
      2 Department of Pathological Sciences, University of Manchester,
      Manchester, UK
      Received 17 October 2001; received in revised form 11 February 2002;
      accepted 19 February 2002

      Abstract
      Background/Aims: Chronic hepatitis C infection is a major world-wide
      problem, frequently progressing to cirrhosis, liver failure or
      hepatoma. The pathological mechanisms of disease progression are
      unclear but oxidant stress may play a role.

      Methods: Markers of lipid peroxidation, antioxidant status, hepatic
      fibrogenesis and liver function were measured in blood or urine from
      42 chronic hepatitis C patients. Fibrosis was graded histologically
      in a subgroup of 33 patients.

      Results: The lipid peroxidation marker 8-isoprostane and the ratio of
      oxidized to reduced glutathione were significantly elevated (P<0.001,
      P=0.006). The antioxidants glutathione, selenium and vitamins A, C
      and E were significantly decreased (all P<0.001) compared to age and
      sex matched controls. Abnormal values were more marked in cirrhotics,
      but significant changes were also observed in the non-cirrhotic
      group. The fibrosis score correlated positively with urinary
      8-isoprostane and type III procollagen peptide and negatively with
      vitamin A.

      Conclusions: Oxidant stress, as reflected in blood and urine by a
      wide range of pro- and antioxidant markers, is a significant feature
      of hepatitis C infection. Although more severe in the cirrhotic
      group, there was clear evidence of oxidant stress in non-cirrhotic
      patients. Antioxidant therapy may therefore have a role in slowing
      disease progression to cirrhosis.

      Keywords: Oxidant stress; 8-Isoprostane; Hepatitis C; Antioxidant;
      Cirrhosis
      *Corresponding author. Department of Gastroenterology, Manchester
      Royal Infirmary, Oxford Road, Manchester, M13 9WL, UK. Tel.:
      +44-161-276-4316; fax: +44-161-276-8779

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