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A pilot study of the effects of d-alpha-tocopherol on hepatic stellate cell activation in chronic hepatitis C

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  • claudine intexas
    A pilot study of the effects of d-alpha-tocopherol on hepatic stellate cell activation in chronic hepatitis C. Author(s): Houglum K Venkataramani A Lyche K
    Message 1 of 1 , Aug 3 10:18 PM
      A pilot study of the effects of d-alpha-tocopherol on hepatic
      stellate cell activation in chronic hepatitis C.

      Author(s): Houglum K Venkataramani A Lyche K Chojkier M

      Journal: Gastroenterology. 1997 Oct; 113(4): 1069-73 1997 0016-5085

      Abstract: BACKGROUND & AIMS: Oxidative stress mediates activation and

      stimulate collagen production of cultured hepatic stellate (Ito)
      cells.
      The aim of this study was to assess whether oxidative stress
      contributes to hepatic fibrogenesis in chronic hepatitis C. METHODS:
      In liver
      biopsy specimens of patients with chronic hepatitis C, the following
      fibrogenesis cascade was analyzed: (1) oxidative stress, determined
      by the
      presence of malondialdehyde protein adducts; (2) activation stellate
      cells as indicated by their expression of alpha-smooth muscle actin;
      (3)
      stimulation of c-myb expression in stellate cells, a critical step in

      the activation of these cells; and (4) induction of collagen gene
      expression as detected by in situ hybridization. RESULTS: Treatment
      with
      d-alpha-tocopherol (1200 IU/day for 8 weeks) in 6 of these patients,
      who
      were refractory to interferon therapy, prevented
      the fibrogenesis cascade observed before antioxidant treatment. In
      addition, d-alpha-tocopherol treatment significantly decreased the
      carbonyl
      modifications of plasma proteins, a sensitive index of oxidative
      stress. However, 8 weeks of d-alpha-tocopherol treatment did not
      significantly affect serum alanine aminotransferase levels, hepatitis
      C virus
      titers, or histological degree of hepatocellular inflammation or
      fibrosis.
      CONCLUSIONS: These data suggest that enhanced oxidative stress
      initiates
      a fibrogenesis cascade in the liver of patients with chronic
      hepatitis
      C.


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