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Vitamin E improves the aminotransferase status of patients suffering from viral hepatitis C

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  • claudine intexas
    Free Radic Res 1997 Dec;27(6):599-605 Vitamin E improves the aminotransferase status of patients suffering from viral hepatitis C: a randomized, double-blind,
    Message 1 of 1 , Aug 3, 2003
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      Free Radic Res 1997 Dec;27(6):599-605


      Vitamin E improves the aminotransferase status of patients suffering
      from viral hepatitis C: a randomized, double-blind,
      placebo-controlled study.

      von Herbay A, Stahl W, Niederau C, Sies H.

      Department of Internal Medicine (GI-Unit), Heinrich-Heine-Universitat
      Dusseldorf, Germany.

      Vitamin E has been shown to protect against liver damage induced by
      oxidative stress in animal experiments. Based on our previous
      findings of diminished vitamin E levels in patients suffering from
      viral hepatitis, we treated 23 hepatitis C patients refractory to
      alpha-interferon therapy with high doses of vitamin E (2 x 400 IU
      RRR-alpha-tocopherol/day) for 12 weeks. Study design: pro-spective
      randomized double-blind crossover design. Clinical parameters
      including alanine aminotransferase (ALT) and aspartate
      aminotransferase (AST) were determined for monitoring the disease
      state, in parallel vitamin E plasma levels and plasma lipids were
      determined. The plasma levels of the alpha-tocopherol were increased
      about 2-fold in all 23 patients. In 11 of 23 patients the clinical
      parameters indicative of liver damage were improved during the phase
      of vitamin E treatment (48% responders). ALT levels in responders
      were lowered by 46% and AST levels were lowered by 35% after 12 weeks
      of vitamin E treatment. Cessation of vitamin E treatment was followed
      by a rapid relapse of ALT and AST elevation, whereas retreatment led
      to a reproducible ALT decrease by 45% and AST decrease of 37% after a
      6 months followup. Since vitamin E is non-toxic even at elevated
      doses ingested over extended periods, we suggest the treatment of
      patients refractory to alpha-interferon therapy suffering from
      hepatitis C with vitamin E as a supportive therapy.

      Publication Types:
      Clinical Trial
      Randomized Controlled Trial

      PMID: 9455695 [PubMed - indexed for MEDLINE]




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