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Amantadine Shows Promise as Added Therapy for Hepatitis C

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  • claudine intexas
    Amantadine Shows Promise as Added Therapy for Hepatitis C (The full text pdf file for this will be available online tomorrow at both Hep C Vets and Hepatitis
    Message 1 of 1 , Jun 9, 2003
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      Amantadine Shows Promise as Added Therapy for Hepatitis C
      (The full text pdf file for this will be available online tomorrow
      at both Hep C Vets and Hepatitis Central)

      Adding amantadine as a third drug to the standard therapy of
      interferon alfa-2a and ribavirin may help hepatitis C sufferers who
      have never been treated, according to a study reported in the June
      issue of Hepatology.

      The use of amantadine, a drug used to treat Parkinson's disease, in
      patients with chronic hepatitis C is controversial because of its
      side effects, including depression, restlessness, irritability and
      others.

      A team of German researchers compared the triple therapy with the
      standard combination therapy of interferon alfa-2a plus ribavirin.

      The study involved 400 previously untreated patients with chronic
      hepatitis C who received triple therapy with amantadine sulphate or
      a placebo for 48 weeks.

      Sustained viral response was observed in 52 percent of the
      amantadine group and in 43.5 percent of the placebo group. Among
      patients with hepatitis C genotype 1 infection, the sustained viral
      response rates were 39 percent for those taking amantadine and 31
      percent in the placebo group.

      The researchers said their findings suggests that amantadine should
      be considered as a potential anti-hepatitis C drug in future
      studies.
      SOURCE:Hepatology 2003 Jun;37(6):1359-1367

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