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Biopsies For Mild Liver Disease Need Four-Year Intervals

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  • claudine intexas
    J Hepatol 2003 Mar;38(3):307-14 Related Articles, Links Rate of natural disease progression in patients with chronic hepatitis C. Zarski JP, Mc Hutchison J,
    Message 1 of 1 , Mar 5, 2003
      J Hepatol 2003 Mar;38(3):307-14 Related Articles, Links


      Rate of natural disease progression in patients with chronic
      hepatitis C.

      Zarski JP, Mc Hutchison J, Bronowicki JP, Sturm N, Garcia-Kennedy R,
      Hodaj E, Truta B, Wright T, Gish R.

      Departement d'Hepato-gastroenterologie, CHU de Grenoble, BP 217,
      38043 Cedex 9, Grenoble, France

      BACKGROUND/AIMS: The interval at which liver biopsy should be
      repeated in untreated patients with chronic hepatitis C is not
      defined. We examined fibrosis change by METAVIR scoring in these
      patients in whom two or more liver biopsies were available.METHODS:
      One hundred and eighty patients with histologically proven chronic
      hepatitis C were studied. Mean delay between biopsies was 3.67+/-2.69
      years and 3.08+/-1.43 in the 16 patients having three biopsies.
      Univariate and multivariate analyses were performed to determine
      factors associated with liver fibrosis progression.RESULTS: Median
      rate of fibrosis progression per year was 0.04 (0.00-0.55) to first
      biopsy, 0.00 (-0.84-1.02) between first and second biopsy (NS), and
      0.17 (0.00-1.50) between second and third biopsy (P<0.05). In
      multivariate analysis, only age at first biopsy >40 years (OR=5)
      (2-12) and alcohol consumption of 1-50 g per day (OR=4) (2-12) and
      more than 50 g per day (OR=8) (3-23) were associated with severe
      fibrosis. The number of patients who increased in fibrosis stage was
      significantly higher after 4 years (P<0.02).CONCLUSIONS: An interval
      of at least 4-5 years is needed between liver biopsies to measure
      change in patients with mild liver disease.

      PMID: 12586296 [PubMed - in process]

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