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Drugs That May Cause Liver Dysfunction or Damage

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  • claudine intexas
    Drugs That May Cause Liver Dysfunction or Damage The liver is the principal organ that is capable of converting drugs into forms that can be readily eliminated
    Message 1 of 1 , Jan 30, 2003
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      Drugs That May Cause Liver Dysfunction or Damage

      The liver is the principal organ that is capable of converting drugs
      into
      forms that can be readily eliminated from the body. Given the
      diversity
      in
      use today and the complex burden they impose upon the liver, it is
      not
      surprising that a broad spectrum of adverse drugs effects on liver
      functions
      and structures has been documented. The reactions range from mild and

      transient changes in the results of liver function tests to complete
      liver
      failure with death of the host. Many drugs may affect the liver
      adversely in
      more than one way, as cited below in several listings. The use of the

      following drugs requires careful monitoring of their effects on the
      liver
      during the entire course of treatment.


      Drugs that may cause ACUTE DOSE-DEPENDENT LIVER DAMAGE (resembling
      acute
      viral hepatitis)

      acetaminophen salicylates (doses over 2 grams daily)

      Drugs that may cause ACUTE DOSE-INDEPENDENT LIVER DAMAGE (resembling
      acute
      viral hepatitis)

      acebutolol indomethacin
      phenylbutazone
      allopurinol isoniazid
      phenytoin
      atenolol ketoconazole
      piroxicam
      carbamazepine labetalol probenecid
      cimetidine maprotiline
      pyrazinamide
      dantrolene metoprolol
      quinidine
      diclofenac mianserin quinine
      diltiazem naproxen
      ranitidine
      enflurane para-aminosalicylic acid
      sulfonamides
      ethambutol penicillins
      sulindac
      ethionamide phenelzine tricyclic
      antidepressants
      halothane phenindione valproic
      acid
      ibuprofen phenobarbital verapamil

      Drugs that may cause ACUTE FATTY INFILTRATION OF THE LIVER

      adrenocortical steroids phenothiazines
      sulfonamides
      antithyroid drugs phenytoin
      tetracyclines
      isoniazid salicylates


      valproic acid
      methotrexate

      Drugs that may cause CHOLESTATIC JAUNDICE

      actinomycin D chlorpropamide
      erythromycin
      amoxicillin/clavulanate cloxacillin
      flecainide
      azathioprine cyclophosphamide
      flurazepam
      captopril cyclosporine

      flutamide
      carbamazepine danazol
      glyburide
      carbimazole diazepam
      gold
      cephalosporins disopyramide
      griseofulvin
      chlordiazepoxide enalapril
      haloperidol
      ketoconazole norethandrolone
      sulfonamides
      mercaptopurine oral contraceptives
      tamoxifen
      methyltestosterone oxacillin
      thiabendazole
      nifedipine penicillamine
      tolbutamide
      nitrofurantoin phenothiazines
      tricyclic
      antidepressants
      nonsteroidal phenytoin
      troleandomycin
      anti-inflammatory drugs propoxyphene verapamil

      Drugs that may cause LIVER GRANULOMAS (chronic inflammatory nodules)

      allopurinol gold phenytoin
      aspirin hydralazine procainamide
      carbamazepine isoniazid quinidine
      chlorpromazine nitrofurantoin sulfonamides
      diltiazem penicillin tolbutamide
      disopyramide phenylbutazone



      Drugs that may cause active chronic hepatitis

      acetaminophen (chronic use, large doses)
      dantrolene methyldopa
      isoniazid nitrofurantoin

      Drugs that may cause liver cirrhosis or fibrosis (scarring)

      methotrexate nicotinic acid

      Drugs that may cause chronic cholestasis (resembling primary biliary
      cirrhosis)

      chlorpromazine/valproic acid (combination
      imipramine thiabendazole
      phenothiazines tolbutamide
      chlorpropamide/erythro-mycin (combination)
      phenytoin

      Drugs that may cause LIVER TUMORS (benign and malignant)

      anabolic steroids oral contraceptives thorotrast
      danazol testosterone

      Drugs that may cause DAMAGE TO LIVER BLOOD VESSELS

      adriamycin dacarbazine thioquanine
      anabolic steroids mercaptopurine vincristine
      azathioprine methotrexate vitamin A
      (excessive doses)
      carmustine mitomycin
      cyclophosphamide/cyclo-sporine (combination)
      oral contraceptives


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