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Postpartum acute exacerbation of chronic hepatitis C with complete response to interferon-

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    Journal of Gastroenterology ISSN: 0944-1174 (printed version) ISSN: 1435-5922 (electronic version) Table of Contents Abstract Volume 37 Issue 8 (2002) pp
    Message 1 of 1 , Sep 18, 2002
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      Journal of Gastroenterology
      ISSN: 0944-1174 (printed version)
      ISSN: 1435-5922 (electronic version)

      Table of Contents

      Abstract Volume 37 Issue 8 (2002) pp 658-662
      DOI 10.1007/s005350200105

      case report: Postpartum acute exacerbation of chronic hepatitis C
      with complete response to interferon-<alpha>

      Makoto Oketani, Toshihiko Shibatou, Katsuhisa Yamashita, Takushi
      Arima, Terukatsu Arima


      The Second Department of Internal Medicine, Faculty of Medicine,
      Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima 890-8520, Japan


      Received: December 21, 2000 / Accepted: April 27, 2001

      We describe a patient with chronic hepatitis C who had severe
      postpartum acute exacerbation of the disease, with marked
      aminotransferase elevations and jaundice. The viral genotype was 2a,
      and the patient had a low viral load. Neither superinfection with
      another hepatotropic virus nor autoantibodies were evident. Markedly
      increased serum concentrations of T-helper (Th) 1-type cytokines and
      cytokine receptors, including interleukin (IL)-8, tumor necrosis
      factor (TNF)-<alpha>, soluble TNF receptor (sTNFR)-p55, sTNFR-p75,
      and soluble Fas antigen (sFas), as well as that of the Th 2-type
      cytokine, IL-10, were present. Complete biochemical and virologic
      response was achieved with interferon (IFN)-<alpha> treatment, which
      decreased cytokine elevations while favoring Th 1 dominance. Acute
      exacerbation of hepatitis C may occur when cellular immune responses
      are activated, as in late pregnancy and in the postpartum period.
      Treating such acute exacerbations immediately with IFN may be highly
      efficacious.


      Key words: hepatitis C virus � acute exacerbation � interferon �
      cytokines � cytokine receptors � postpartum period

      Article in PDF format (60 KB)


      --------------------------------------------------------------------------------

      Online publication: August 29, 2002
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      � Springer-Verlag Tokyo 2002


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