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SAMe and possible drug interaction

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  • claudine intexas
    5-HTP (5-Hydroxytryptophan), SAMe (S-Adenosylmethionine) Possible Harmful Interaction The body uses the natural substance 5-hydroxytryptophan (5-HTP) to
    Message 1 of 1 , Sep 1, 2002
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      5-HTP (5-Hydroxytryptophan), SAMe (S-Adenosylmethionine)
      Possible Harmful Interaction

      The body uses the natural substance 5-hydroxytryptophan (5-HTP) to
      manufacture serotonin, and supplemental forms have been used for
      treating depression and migraine headaches.

      S-adenosylmethionine (SAMe) is a naturally occurring compound derived
      from the amino acid methionine and the energy molecule adenosine
      triphosphate (ATP). SAMe is widely used as a supplement for treating
      osteoarthritis and depression.

      Based on one case report and current thinking about how they work,
      SAMe and 5-HTP should not be taken with SSRIs, as they might increase
      the risk of serotonin syndrome.

      This syndrome is a toxic reaction brought on by too much serotonin
      activity. The condition requires immediate medical attention, with
      symptoms including anxiety, restlessness, confusion, weakness,
      tremor, muscle twitching or spasm, high fever, profuse sweating, and
      rapid heartbeat.

      The report describes a case of apparent serotonin syndrome in an
      individual taking SAMe with clomipramine, a tricyclic antidepressant
      that increases serotonin activity.1

      Although SAMe is not currently known to affect serotonin, it does
      appear to have antidepressant effects and may in some way increase
      serotonin activity.

      Because SSRIs increase serotonin activity even more than
      clomipramine, a similar problem might occur if you combine SAMe with
      an SSRI.

      The supplement 5-HTP is used by the body to manufacture serotonin, so
      it could also increase the risk of serotonin syndrome when combined
      with an SSRI.


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