Loading ...
Sorry, an error occurred while loading the content.
 

Age at Infection Influences Outcome of Hepatitis C

Expand Messages
  • claudine intexas
    Age at Infection Influences Outcome of Hepatitis C NEW YORK (Reuters Health) Jul 19 - In patients with transfusion-associated hepatitis C, age at infection
    Message 1 of 1 , Aug 1, 2002
      Age at Infection Influences Outcome of Hepatitis C

      NEW YORK (Reuters Health) Jul 19 - In patients with
      transfusion-associated hepatitis C, age at infection influences the
      likelihood of progression to cirrhosis, according to Italian
      researchers.
      Dr. Dario Conte of Ospidale Maggiore, Milan, and colleagues note that
      during the 1980s, before screening of donors was introduced, about
      10% of patients receiving transfusions in Italy developed hepatitis
      C.

      In order to assess risks factors for progression to cirrhosis, the
      researchers eventually identified 268 patients with hepatitis C who
      recalled a single and precisely dated transfusion event and showed no
      other cause of chronic liver disease. All underwent ultrasound-guided
      liver biopsy.

      As reported in the June 15th issue of Blood, 54 of these patients
      (20.1%) were found to have cirrhosis, at a mean of 18.4 years after
      blood transfusion. Multivariate analysis showed that this was
      independently associated with serum levels of alanine
      aminotransferase and with age at biopsy, duration of followup and age
      at infection.

      The investigators calculate that over a period of 30 years, patients
      aged 21 to 30 years at the time of hepatitis C virus infection are
      4.51 times more likely to develop cirrhosis than those aged 20 years
      or less. In those older than 31 years at infection, the corresponding
      risk ratio is 12.29.

      The researchers recommend that "an aggressive therapeutic approach
      should be adopted in patients infected by hepatitis C virus at an
      older age to prevent progression to end-stage liver disease."

      Blood 2002;99:4588-4591.


      __________________________________________________
      Do You Yahoo!?
      Yahoo! Health - Feel better, live better
      http://health.yahoo.com
    Your message has been successfully submitted and would be delivered to recipients shortly.