Loading ...
Sorry, an error occurred while loading the content.

Thyrotoxicosis induced by alpha-interferon therapy in chronic viral hepatitis

Expand Messages
  • claudine intexas
    Abstract Clinical Endocrinology Volume 56 Issue 6 Page 793 - June 2002 Thyrotoxicosis induced by alpha-interferon therapy in chronic viral hepatitis Vincent
    Message 1 of 1 , Jun 26, 2002
    • 0 Attachment
      Abstract

      Clinical Endocrinology
      Volume 56 Issue 6 Page 793 - June 2002

      Thyrotoxicosis induced by alpha-interferon therapy in chronic viral
      hepatitis
      Vincent Wong*, Angela Xi-Li Fu*, Jacob George and N. Wah Cheung*

      Summary

      background and objectiveIt has been well documented that treatment of
      chronic hepatitis B and C infection with interferon alpha (IFN-) can
      lead to the induction of thyroid autoantibodies and hypothyroidism.
      Thyrotoxicosis, however, is less frequently observed and less well
      characterized.

      patients and methodsWe reviewed the medical records of patients who
      developed thyrotoxicosis while receiving IFN- for either chronic
      hepatitis B or C infection at Westmead Hospital between 1996 and
      March 2001.

      resultsTen patients (four males and six females) were found to have
      biochemical thyrotoxicosis. The patients could be divided into two
      groups with different characteristics. The first group consisted of
      six patients who had clinical manifestations consistent with Graves
      disease, with either diffuse uptake in thyroid scintigraphy and/or
      positive thyroid-stimulating antibodies. They all required prolonged
      treatment with antithyroid medications. The second group included
      three patients who had transient thyrotoxicosis, with progression to
      hypothyroidism after resolution of thyrotoxicosis.

      conclusionOur study suggests that IFN therapy may provoke two
      different forms of thyrotoxicosis: a Graves disease picture or a
      biphasic thyroiditis pattern. The two entities should be
      differentiated, as they have different implications for treatment.


      QuickSearch in:

      PubMed (MEDLINE)Synergyfor
      Authors:
      Vincent Wong
      Angela Xi-Li Fu
      Jacob George
      N. Wah Cheung

      Affiliations
      *Department of Diabetes and Endocrinology, Westmead Hospital and
      Storr Liver Unit, Westmead Millennium Institute, University of
      Sydney, Westmead Hospital, NSW, Australia

      Correspondence to
      Correspondence: Dr Vincent Wong, Department of Diabetes and
      Endocrinology, Westmead Hospital, Hawkesbury Road, Westmead, NSW
      2145, Australia. Fax: (612) 9635 5691; E-mail: swavwong@...


      __________________________________________________
      Do You Yahoo!?
      Yahoo! - Official partner of 2002 FIFA World Cup
      http://fifaworldcup.yahoo.com
    Your message has been successfully submitted and would be delivered to recipients shortly.