7285Treatment of Acute Hepatitis C with Interferon Alfa-2b
- Oct 1, 2001NATAP - www.natap.org
Treatment of Acute Hepatitis C with Interferon Alfa-2b
(early release from NEJM of article in Oct 1 not yet
At the Spring 2001 DDW Conference, 2 studies of
acute HCV were reported, one of which was this same
German study. Here
link to the report on those studies:
Elmar Jaeckel, M.D., Markus Cornberg, M.D., Heiner
Santantonio, M.D., Julika Mayer, M.D., Myrga Zankel,
Pastore, M.D., Manfred Dietrich, M.D., Christian
Manns, M.D., and the German Acute Hepatitis C Therapy
(Notice: Because of its potential clinical
implications, this article
being published early [on October 1, 2001]. It will
appear in the
issue of the Journal. Click on "PDF of this article"
for the full
Background In people who are infected with the
hepatitis C virus (HCV)
chronic infection often develops and is difficult to
determine whether treatment during the acute phase
could prevent the
development of chronic infection.
Methods- Between 1998 and 2001, we identified 44
who had acute hepatitis C. Patients received 5 million
U of interferon
alfa-2b subcutaneously daily for 4 weeks and then
three times per week
another 20 weeks. Serum HCV RNA levels were measured
before and during
therapy and 24 weeks after the end of therapy.
Results- The mean age of the 44 patients was 36 years;
25 were women.
became infected with HCV through intravenous drug use,
14 through a
needle-stick injury, 7 through medical procedures, and
contact; the mode of infection could not be determined
in 4. The
from infection to the first signs or symptoms of
hepatitis was 54 days,
the average time from infection until the start of
therapy was 89 days.
the end of both therapy and follow-up, 42 of the 43
patients who have
completed follow-up (98 percent) had undetectable
levels of HCV RNA in
and normal serum alanine aminotransferase levels.
Levels of HCV RNA
undetectable after an average of 3.2 weeks of
treatment. Therapy was
tolerated in all but one patient, who stopped therapy
after 12 weeks
of side effects.
Conclusions- Treatment of acute hepatitis C with
Do You Yahoo!?
Listen to your Yahoo! Mail messages from any phone.