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16169Fw: NATAP (correction): Fatty Liver (steatosis) & NRTIs

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  • Alley Pat
    Jul 2, 2006
      NATAP http://natap.org/
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      Hepatic Steatosis Is Associated with Fibrosis, Nucleoside Analogue Use, and Hepatitis C Virus Genotype 3 Infection in HIV-Seropositive Patients: Steatosis was present in 69% of patients - (06/29/06)
      "....Steatosis was present in 69% of patients....Factors associated with steatosis included use of dideoxynucleoside analogues, such as didanosine and stavudine...presence of steatosis was associated with fibrosis..steatosis is multifactorial in nature and may play a contributory role in the progression of liver disease in HIV-infected patients..."

      Dideoxynucleoside Analogues Should Be Used Cautiously in Patients with Hepatic Steatosis - (06/29/06) EDITORIAL
      "....In patients with HCV genotype 1 infection, host factors, such as excessive alcohol intake, age, central obesity, and hyperlipidemia, are predominant causes of hepatic steatosis.... a component of the metabolic syndrome, a condition generally associated with insulin resistance...Hepatic steatosis, defined as abnormal lipid accumulation in hepatocytes, is found in almost one-third of the United States population. As a result of increases in the prevalences of obesity, insulin resistance, and hyperlipidemia, the number of people with hepatic steatosis continues to expand....the presence of steatosis can accelerate disease progression.."


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