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Fwd: Risk of Diabetes in South Asians

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  • mohammad imran
    Message 1 of 1 , Mar 31, 2005
      Begin forwarded message:

      > From: Mayraj Fahim <fmayraj@...>
      > Date: March 31, 2005 1:28:42 PM EST
      > To: imran@...
      > Subject: Risk of Diabetes in South Asians
      > Asian Indian
      > Ancestry Raises
      > Risk Of Diabetes
      > PEOPLE OF ASIAN INDIAN ancestry are at increased risk for type 2
      > diabetes, even when they are thin, according to articles in the
      > December 2003 and June  2004 issues of the Journal of Clinical
      > Endocrinology and  Metabolism. The researchers found that people of
      > Indian, Pakistani, or Bangladeshi ancestry-all considered "Asian
      > Indian" for these studies-are metabolically and genetically different
      > from those of European descent. (Traditionally, anthropologists have
      > classified Asian Indians as "Caucasians" In these studies, however,
      > those descended from Europeans are referred to as "Caucasians")
      > Scientists already knew that insulin resistance and type 2 diabetes
      > are common in India. The new research studied people living in the
      > United States.
      > In the December 2003 study, the research team looked at whether two
      > genes suspected to cause insulin resistance occur more often among
      > people of Asian Indian ancestry than among Caucasians. They also
      > investigated whether people who had these genes were more insulin
      > resistant than those who didn't.
      > There were 738 subjects of European ancestry and 638 subjects of Asian
      > Indian ancestry; some of the Asian Indians were recent immigrants, and
      > others had been born in the United States. Genetic tests found that
      > one of the two suspect genes, called PC-1 121 Q, occurred
      > significantly more often in the Asian Indians. Blood tests also showed
      > that Asian Indians with this gene were less insulin sensitive than
      > Asian Indians without it. Among Caucasians, the gene did not affect
      > insulin sensitivity in this study.
      > The researchers concluded that the PC-1 121Q gene is strongly
      > associated with insulin resistance among Asian Indians in the United
      > States. Because insulin resistance raises the risk of type 2 diabetes,
      > people with this gene are likely more prone to diabetes. In the June
      > 2004 study, the researchers compared insulin-resistant Asian Indian
      > men with less-insulin-resistant Caucasian men. They sought to find out
      > whether the men's fat cells released similar amounts of leptin,
      > adiponectin, and none sterified fatty acids (NEFA). (Obese people
      > produce high levels of leptin and NEFA and low levels of adiponectin;
      > these abnormalities may help cause the insulin resistance that often
      > accompanies obesity.) The subjects were 79 Asian Indian men and 61
      > Caucasian men; most of the Asian Indian men were recent immigrants to
      > the United States. The Caucasians were significantly heavier than the
      > Asian Indian men and had more total body fat but less trunk fat (which
      > is linked to insulin resistance). However, the percentage of total
      > body weight that could be attributed to fat was similar in the two
      > groups. In other words, even though the Asian Indian men were much
      > thinner than the Caucasian men, they had a similar proportion of fat
      > and more of it was in the unhealthy trunk area.
      > The researchers found that although fasting plasma glucose levels were
      > similar in the two groups, the Asian Indian men had significantly
      > higher fasting plasma insulin levels. In addition, the Asian Indians
      > had higher NEFA and leptin levels and lower adiponectin levels than
      > the Caucasian men did.
      > The Asian Indians' higher levels of NEFA and leptin and lower levels
      > of adiponectin suggest that the bodies of thin Asian Indians are
      > metabolically similar in some ways to those of overweight Caucasians.
      > The researchers concluded that Asian Indians may have a fat cell
      > defect that makes them produce the wrong quantities of these three
      > substances and so leads to insulin resistance, even when a person
      > isn't overweight. Insulin resistance, in turn, presumably leads to a
      > higher risk of type 2 diabetes.
      > Together, these studies suggest that people of Asian Indian ancestry
      > are genetically more prone to type 2 diabetes. Thus, it is extra
      > important for people with such ancestry to stay as thin as possible,
      > to exercise regularly, and to be aware of the symptoms of diabetes.
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