Re: New Type of Yeast
- --- In Distillers@yahoogroups.com, "Mr. Brew Diggity Dog"
> Hey all, I haven't been here in a while, but i caught a tinylittle
> article in the latest BusinessWeek about a new strain of yeast and30~40%
> immediately thought of the group. In a nutshell: they genetically
> engineered yeast to process glucose AND xylose. They claim a
> increase in yield. Wow! But we won't get our hands on it anytimeetc.
> soon. It's the property of Purdue University & they're going to
> license the hell out of it.
> If you care about the details: Xylose makes up roughly 30~40% of
> celluloid materials like corn stalks, grass, wood chips, leaves,
> They added just three genes to plain old Saccharomyces yeast sothat
> it can break down both sugars at the same time.seems
> This is something that's been worked on for a looong time & it
> that Nancy Ho (the Purdue scientist who figured all this out) didton
> this in 1993. That means they've been fiddling with that yeast for
> the last ten years.
> They've leased the yeast to a Canadian company http://www.Iogen.ca
> that uses it to produce ethanol suitable for mixing with gas. If
> anyone wants to break the numbers down: they claim 75 Gallons per
> of straw. with roughly 2/3 of the straw being converted. Sorry Iof
> can't give more hard #'s but i didn't have access to the full text
> her paper.seems
> Would this stuff be drinkable w/no funny taste? Something just
> wrong about raking the yard then tossing the leaves into theNancy and Purdue aren't the only players in that lucrative
> fermenter. Still, any
> Canadians wanna slip over to to Ottowa and grab us a sample?
"The race to create new microbes capable of fermenting the full
range of sugars found in biomass has followed several successful
pathways. Dr. Lonnie Ingram at the University of Florida started
with an E. coli bacterium capable of metabolizing multiple sugars
and added the ability to make ethanola feat for which he received
U.S. Patent #5,000,000 in 1990. His work was sponsored by the
Biofuels Program and others.
Taking an approach that complements Dr. Ingram's E. coli, other DOE
researchers started with the bacterium Zymomonas, a naturally
efficient ethanol-producing bacterium, and added the capability for
utilizing multiple sugars. (see "Zymomonas recognized by scientific
DOE also helped support Purdue's Dr. Nancy Ho, who started with
the "industrial workhorse" for ethanol productionthe yeast
Saccharomycesand added the capability for utilizing multiple sugars.
All three organisms are now being tested by industrial partners for
use in bioethanol production."
Full article here...
Other related articles...
Transcriptional profiling of
genetically engineered yeast by
DNA microarray: DNA microarray
technology provides the
simultaneous measurement of
the expression of thousands of
genes (or a whole genome) in a
single analysis. Shown here is
the profile of the genomic
expression of the genetically
yeast during fermentation of
glucose and xylose obtained by
DNA microarrays. This yeast
was developed at Purdue and
is the world's most effective
microorganism for fuel ethanol
production. This analysis will
be able to reveal the specific
genes that need to be modified
to further improve the
effectiveness of our engineered
yeast to coferment glucose,
xylose, and other sugars to
NANCY W. Y. HO
and Miroslav Sedlak