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Re: [Ashkenazi-Q] Re: Ashkenazi Jewish Paper: Signatures of founder effects, admixture, and selection in the Ashkenazi Jewish population

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  • K E EPHRAIM
    Thanks for the reader digest version. I have found that reading many of the articles to be tedious and labor intensive. With 2 small children around it is
    Message 1 of 16 , Sep 10, 2010
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      Thanks for the reader digest version.  I have found that reading many of the articles to be tedious and labor intensive.  With 2 small children around it is hard to concentrate.  I will pass this version on to my dad who is the Q1b.
      ----- Original Message -----
      Sent: Saturday, August 28, 2010 12:28 AM
      Subject: Re: [Ashkenazi-Q] Re: Ashkenazi Jewish Paper: Signatures of founder effects, admixture, and selection in the Ashkenazi Jewish population

       

      Sorry to bust the victimization bubble, but our migration into Rome and the Italian Peninsuala dates to the Hasmonean Period.  Emmisaries were sent to Rome to gain assistance against the Greeks.  (A familiar theme in our history!)  Merchants, craftsmen, etc. soon followed.
       
      Mike Jaron

      On Fri, Aug 27, 2010 at 11:40 PM, Dave <dshoward@...> wrote:
       

      Hi Rebekah and Others,

      I did read the paper and the supplemental materials. I dear say that I
      found it very difficult to read albeit very interesting. Here is a
      Readers Digest version - filtered through the brain of a tax lawyer.

      The focus was on genetically linked health issues among the descendants
      of Ashkenazi Jews in Northern Europe. This group is referred to as AJ
      throughout the paper. Comparisons were made between the other Europeans
      (Euro) and European American (EA) Groups.

      Here are some interesting discoveries.

      AJ apparently came from the Middle East a pretty diverse group
      genetically and pretty closely related to other groups in the same area.
      AJ are more genetically diverse than their Euro and EA neighbors. But it
      is old time diversity from long ago. The AJ intermarried a bit with
      southern Europeans (mostly Italians) and then later intermarried a bit
      with northern Europeans. At the end of the day the AJ have their own
      genetic signature and are closely related to their former middle eastern
      neighbors but slightly more closely related to their Euro and EA
      neighbors.

      This would be consistent with the notion that Jews in Israel were taken
      as slaves to Rome about 70 AD and later migrated north to be the core
      founders of the AJ.

      The researchers looked into 20 diseases found more often among the AJ
      and did find higher than expected inbreeding among the AJ.

      They tried to find some physical quality linked to high IQ and found
      that this quality may have been selected for independently from any
      other quality. Any linkage to any of six diseases is by chance and not
      selection.

      They found the AJ to be 60% to 80% lactose intolerant. This is not
      common at all among their Euro or EA neighbors. The researchers felt
      that there was a sweep adaptation through Europe about 2,000 years ago
      when cows were introduced to the area. The AJ migrated into the area
      after this adaptation.

      They did confirm that AJ men had a genetically linked ability to
      metabolize alcohol and accordingly less drunkenness and alcohol abuse by
      a factor of 2.5x better than their European neighbors. They found that
      this ability may also be linked to a very good immune response to
      bacterial and viral infections. There is a theory that this improved
      alcohol tolerance and immune response developed while the Jewish people
      were in captivity in Babylon.

      The group that did the research and published the paper were focused on
      health issues among the AJ.

      There is nothing unique to yDNA Haplogroup Q but very interesting to
      anyone with Ashkenazi Jewish ancestors.

      A big thank you to Rebekah for sharing this interesting article with us.

      Dave Howard


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