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50 Deadly Consequences of Lab Animal Experiments

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  • Artemisd123@hotmail.com
    Please review and save this information. It is important to remember (memorize?) a few of these points so you can use them in discussions with friends and
    Message 1 of 2 , Jul 16, 2001
      Please review and save this information. It is
      important to remember (memorize?) a few of these points
      so you can use them in discussions with friends and
      family members.

      Source: Americans for Medical Advancement
      http://www.curedisease.com/Harms.html

      You can also order this as a pamphlet for $1.00 through the AFMA
      website above.

      Please save this info and reference it in your letters and
      discussions with friends, co-workers and family members. We need to
      get the word out and "chip away at the mountainous lie of animal
      research."

      50 DEADLY CONSEQUENCES OF LAB ANIMAL EXPERIMENTS
      Americans for Medical Advancement
      http://www.curedisease.com/Harms.html

      Smoking was thought non-carcinogenic because smoking-related cancer
      is difficult to reproduce in lab animals. Many continued to smoke and
      to die from cancer.[2]

      Benzene was not withdrawn from use as an industrial chemical despite
      clinical and epidemological evidence that exposure caused leukemia in
      humans, because manufacturer-supported tests failed to reproduce
      leukemia in mice.[1]

      Animal experiments on rats, hamsters, guinea pigs, mice, monkeys, and
      baboons revealed no link between glass fibers and cancer. Not until
      1991, due to human studies, did OSHA label it carcinogenic.[3][4][5]

      Though arsenic was a known human carcinogen for decades, scientists
      still found little evidence in animals to support the conclusion as
      late as 1977.[6] This was the accepted view until it was produced in
      lab animals.[7][8][9]

      Many continued to be exposed to asbestos and die because scientists
      could not reproduce the cancer in lab animals.

      Pacemakers and heart valves were delayed in development because of
      physiological differences between animals they were designed on and
      humans.

      Animal models of heart disease failed to show that a high
      cholesterol/high fat diet increases the risk of coronary artery
      disease. Instead of changing their eating habits to prevent the
      disease, people continued their lifestyles with a false sense of
      security.

      Patients received medications that were harmful and/or ineffective
      due to animal models of stroke.

      Animal studies predicted that beta-blockers would not lower blood
      pressure. This withheld their development.[10][11][12] Even animal
      experimenters admitted the failure of animal models of hypertension
      in this regard, but in the meantime, there were thousands more stroke
      victims.

      Surgeons thought they had perfected radial keratotomy, surgery
      performed to enable better vision without glasses, on rabbits, but
      the procedure blinded the first human patients. The rabbit cornea is
      able to regenerate on the underside, whereas the human cornea can
      only regenerate on the surface. Surgery is now performed only on the
      surface.

      Combined heart lung transplants were also "perfected" on animals, but
      the first 3 patients all died within 23 days.[13] Of 28 patients
      operated on between 1981 and 1985, 8 died peri-operatively, and 10
      developed obliterative bronchiolitis, a lung complication that the
      experimental dogs did not get. Of those 10, 4 died and 3 never
      breathed again without the aid of a respirator. Obliterative
      bronchiolitis turned out to be the most important risk of the
      operation.[14]

      Cyclosporin A inhibits organ rejection, and its development was
      watershed in the success of transplant operations. Had human evidence
      not overwhelmed unpromising evidence from animals, it would never
      have been released.[15]

      Animal experiments failed to predict the kidney toxicity of the
      general anesthetic methoxyflurane. Many people lost all kidney
      function.

      Animal experiments delayed the use of muscle relaxants during general
      anesthesia.

      Research on animals failed to reveal bacteria as a cause of ulcers
      and delayed treating ulcers with antibiotics.

      More than half of the 198 new medications released between 1976 and
      1985 were either withdrawn or relabeled secondary to severe
      unpredicted side effects.[16] These side effects included
      complications like lethal dysrhythmias, heart attacks, kidney
      failure, seizures, respiratory arrest, liver failure, and stroke,
      among others.

      Flosint, an arthritis medication, was tested on rats, monkeys and
      dogs; all tolerated the medication well. In humans, however it caused
      deaths.

      Zelmid, an antidepressant, was tested on rats and dogs without
      incident. It caused severe neurological problems in humans.

      Nomifensine, another antidepressant, was linked to kidney and liver
      failure, anemia, and death in humans. Animal testing had given it a
      clean, side effect-free bill of health.

      Amrinone, a medication used for heart failure, was tested on numerous
      animals and was released without trepidation. Humans developed
      thrombocytopenia, a lack of the type of blood cells that are needed
      for clotting.

      Fialuridine, an antiviral medication, caused liver damage in 7 out of
      15 people. 5 eventually died and 2 more needed liver transplants.[17]
      It worked well in woodchucks.[18][19]

      Clioquinol, an antidiarrheal, passed tests in rats, cats, dogs and
      rabbits. It was pulled off the shelves all over the world in 1982
      after it was found to cause blindness and paralysis in humans.

      Eraldin, a medication for heart disease, caused 23 deaths despite the
      fact that no untoward effects could be shown in animals. When
      introduced, scientists said it noted for the thoroughness of the
      toxicity studies on animals. It caused blindness and deaths in
      humans. Afterwards, scientists were unable to reproduce these results
      in animals.[20]

      Opren, an arthritis medication, killed 61 people. Over 3500 cases of
      severe reactions have been documented. Opren had been tested on
      monkeys and other animals without problems.

      Zomax, another arthritis drug, killed 14 people and caused many more
      to suffer.

      The dose of isoproterenol, a medication used to treat asthma, was
      worked out in animals. Unfortunately, it was much too toxic for
      humans. 3500 asthmatics died in Great Britain alone due to overdose.
      It is still difficult to reproduce these results in animals.[21][22]
      [23][24][25][26]

      Methysergide, a medication used to treat headaches, led to
      retroperitoneal fibrosis, or severe scarring of the heart, kidneys,
      and blood vessels in the abdomen.[27] Scientists have been unable to
      reproduce this in animals.[28]

      Suprofen, an arthritis drug, was withdrawn from the market when
      patients suffered kidney toxicity. Prior to its release researchers
      had this to say about the animal tests:[29][30] "...excellent safety
      profile. No ...cardiac, renal, or CNS [central nervous system]
      effects in any species."

      Surgam, another arthritis drug, was designed to have a stomach
      protection factor that would prevent stomach ulcers, a common side
      effect of many arthritis drugs. Although promising in lab animal
      tests, ulcers occurred in human trials.[31][32]

      Selacryn, a diuretic, was thoroughly tested on animals. It was
      withdrawn in 1979 after 24 people died from drug induced liver
      failure.[33][34]

      Perhexiline, a heart medication, was withdrawn when it produced liver
      failure that had not been predicted by animal studies. Even when they
      knew they were looking for a particular type of liver failure, they
      could not induce it in animals.[35]

      Domperidone, designed as a treatment for nausea and vomiting, made
      human hearts beat irregularly and had to be withdrawn. Scientists
      were unable to reproduce this in dogs even with 70 times the normal
      dose.[36][37]

      Mitoxantrone, a treatment for cancer produced heart failure in
      humans. It was extensively tested on dogs, which did not manifest
      this effect.[38][39]

      Carbenoxalone was supposed to prevent formation of gastric ulcers but
      caused people to retain water to the point of heart failure. After
      scientists knew what it did to humans they tested it on rats, mice,
      monkeys, rabbits, without reproducing this effect. [40][41]

      Clindamycin, an antibiotic, causes a bowel condition called
      pseudomenbraneous colitis. It was tested in rats and dogs every day
      for one year. They tolerate doses 10 times greater than humans.[42]
      [43][44]

      Animal experiments did not support the efficacy of valium-type drugs
      during development or after.[45][46]

      Pharmacia & Upjohn discontinued clinical tests of its Linomide
      (roquinimex) tablets for the treatment of multiple sclerosis after
      several patients suffered heart attacks. Of 1,200 patients, 8
      suffered heart attacks as a result of taking the medication. Animal
      experiments had not predicted this.

      Cylert (pemoline), a medication used to treat Attention Deficit
      Hyperactive Disorder, caused liver failure in 13 children. Eleven
      either died or needed a liver transplant.

      Eldepryl (selegiline), a medication used to treat Parkinson's
      disease, was found to induce very high blood pressure. This side
      effect has not been seen in animals, where it is used to treat senile
      dementia and endocrine disorders.

      The diet drug combination of fenfluramine and dexfenfluramine was
      linked to heart valve abnormalities and taken off the market although
      animal studies had never revealed heart abnormalities."[47]

      The diabetes medication troglitazone, better known as Rezulin, was
      tested on animals without significant problems, but caused liver
      damage in humans. The company admitted that at least one patient had
      died and another had to undergo a liver transplant as a result.[48]

      The plant digitalis has been used for centuries to treat heart
      disorders. However, clinical trials of the digitalis-derived drug
      were delayed because it caused high blood pressure in animals. Human
      evidence overrode. As a result, digoxin, an analogue of digitalis,
      has saved countless lives. Many more could it have survived had
      digitalis been released sooner.[49][50][51][52]

      FK 506, now called Tacrolimus, is an anti-rejection agent that was
      almost shelved before proceeding to clinical trials due to severe
      toxicity in animals.[53][54] Animal studies suggested that the
      combination of FK 506 with cyclosporin might prove more useful.[55]
      In fact, just the opposite proved true in humans.[56]

      Animal experiments suggested that corticosteroids would help septic
      shock, a severe bacterial infection of the blood.[57][58]
      Unfortunately, humans reacted differently. This treatment increased
      the death rate in cases of septic shock.[59]

      Despite the ineffectiveness of penicillin in his rabbits, Alexander
      Fleming used the antibiotic on a very sick patient since he had
      nothing else to try. Luckily, Fleming's initial tests were not on
      guinea pigs or hamsters, it kills them. Howard Florey, the Nobel
      Prize winner credited with co-discovering and manufacturing
      penicillin, stated: "How fortunate we didn't have these animal tests
      in the 1940s, for penicillin would probably never been granted a
      license, and possibly the whole field of antibiotics might never have
      been realized."

      Fluoride was withheld as a cavity preventative initially because it
      caused cancer in rats.[60][61][62]

      The notoriously dangerous drugs thalidomide and DES were tested in
      animals and released. Tens of thousands suffered and died as a
      result.

      Animal experiments misinformed researchers about how rapidly HIV
      replicates. Based on this false information, patients did not receive
      prompt therapies and their lives were shortened.

      Animal-based research delayed the development of the polio vaccine,
      according to Dr. Albert Sabin, its inventor. The first rabies and
      polio vaccines worked well on animals but crippled or killed the
      people who tried them.

      Researchers who work with animals have succumbed to illness and death
      due to exposure to diseases that though harmless to the animal host
      (such as Hepatitis B) but kill humans.

      Time, money, and resources devoted to these experiments could have
      gone to human-based research. Clinical studies, in vitro research,
      autopsies, post-marketing drug surveillance, computer modeling,
      epidemiology, and genetic research pose no hazard to humans and
      provide accurate results. Importantly, animal experiments have
      exhausted resources that could have been dedicated to educating the
      public about health hazards and health maintenance, therein
      diminishing the incidence of disease that require treatment.

      ANIMAL EXPERIMENTATION DOES NOT MAKE SENSE

      HUMAN-BASED SCIENCE PREVENTS DISEASE AND CREATES VALID THERAPIES

      REFERENCES:

      Sax, N. Cancer-causing Chemicals Van Nostrand 1981
      Lancet, June 25, 1977 p1348-9
      The Guardian, July 20, 1991
      Occupational Lung Disorders, Butterworth 1982
      Toxicology & Industrial Health, 1990, vol.6, p293-307
      J Nat Cancer Inst 1969, vol.42, 1045-52
      Br J Cancer, 1947, vol.1, p 192-251
      Advances in Modern Toxicology, vol.2, Wiley, 1977
      J Nat Cancer Inst, 1962, vol.5, p 459
      Fitzgerald, D. The development of new cardiovascular drugs in Recent
      Developments in Cardiovascular Drugs eds. Coltart and Jewitt,
      Churchill Livingstone 1981
      Perspectives in Biology & Medicine, 1980 Part 2, S9-S24
      Pharmacy International Feb. 1986; p33-37
      Lancet, i, p 130-2, 1983
      Lancet, 1, no. 8480 p 517-9, March 8, 1996
      Annals of Internal Medicine 1984, vol.101, 667-682
      GAO/PEMD-90-15 FDA Drug Review: Postapproval Risks 1976-1985
      NEJM 333;1099-1105, 1995
      J NIH Res, 1993, 5, 33-35
      Nature, 1993, July 22, p 275
      Nature, 1982, April 1, p 387-90 and Br Med J, 1983, Jan 15, p 199-202
      and Drug Monitoring, 1977 and Pharmacologist, 1964, vol. 6, p 12-26
      and Pharmacology: Drug Actions and Reac and Advances in Pharm, 1963,
      vol. 2, 1-112 and Nature, 1982, April 1, p 387-390
      Pharmacologist, 1971, vol.18, p 272
      Br J of Pharm 1969Vol. 36; p35-45
      Inman, W. H. Monitoring for Drug Safety, MTP Press, 1980
      Am Rev Resp Diseases, 1972, vol.105, p883-890
      Lancet, 1979, Oct.27, p 896
      Toxicology and Applied Pharmacology 1965, vol. 7; p1-8
      Animal Toxicity Studies: Their Relevance for Man, Quay Pub. 1990
      Br Med J, 1974, May 18, p 365-366
      Drug Withdrawl from Sale PJB Publications, 1988
      Pharmacology, 1983, vol.27(suppl 1), 87-94 and FDA Drug Review:
      Postapproval Risks 1976-1985 (US GAO April 1990
      Gut, 1987, vol.28, 515-518
      Lancet, Jan 10, 1987, 113-114
      Toxicolo Letters, 1991, vol.55, p 287-93
      Drug Withdrawl from Sale, PJB1988
      Reg Tox & Pharm,1990,vol.11,288-307 and Postgraduate Med J, 1973,
      vol.49, April Suppl., 125-129 and 130
      Drugs, 1982, vol.24, p 360-400
      Animal Toxicity Studies Quay, 1990
      Lancet, 1984, July 28, p 219-220
      Matindale: The Extra Pharmacopoeia, 29th edition, Pharmaceutical
      Press, 1989)
      Br Nat Form, no.26, 1993
      Reg Tox & Pharm, 1990, vol.11, p 288-307
      Br Med J, 1983, Jan 15, p 199-202
      Br Nat Form, no.26, 1993
      Tox & Appl Pharm, 1972, vol. 21, p 516-531
      The Benzodiazepines MTP Press1978
      Drugs and Therapeutics Bulletin,1989, vol.27, p 28
      as quoted in Activate For Animals Oct. 1997 The American
      Antivivisection Society
      Parke-Davis letter dated Oct. 31, 1996
      Sneader, W. Drug Discovery: The Evolution of Modern Medicine Wiley,
      1985
      Lewis, T. Clinical Science Shaw & Sons Ltd. 1934
      Federation Proceedings 1967, vol.26, 1125-30
      Toxicology In Vitro 1992, vol.6, 47-52
      JAMA, 1990, April 4, p1766
      Lancet,1989, July 22, p 227
      Lancet, 1989, Oct 28, p1000-1004
      Hepatology,1991, vol.13, 1259-1260
      Drugs and Therapeutics Bulletin, 1990, vol.28, p 74-75
      Anesthesiology: Proceedings of the VI World Congress of
      Anesthesiology, Mexico City 1977
      NEJM, 1987, Sep. 10, p 653-658
      The Causes of Cancer, 1981, Oxford Press
      J NIH Res, 1991, vol.3, p46
      Nature, 1991, Feb 28, p732
    • Artemisd123@hotmail.com
      50 Deadly Consequences of Lab Animal Experiments Please review and save this information. It is important to remember (memorize?) a few of these points so you
      Message 2 of 2 , Nov 10, 2001
        50 Deadly Consequences of Lab Animal Experiments

        Please review and save this information. It is
        important to remember (memorize?) a few of these points
        so you can use them in discussions with friends and
        family members.

        Source: Americans for Medical Advancement
        http://www.curedisease.com/Harms.html

        You can also order this as a pamphlet for $1.00 through the AFMA
        website above.

        Please save this info and reference it in your letters and
        discussions with friends, co-workers and family members. We need to
        get the word out and "chip away at the mountainous lie of animal
        research."

        50 DEADLY CONSEQUENCES OF LAB ANIMAL EXPERIMENTS
        Americans for Medical Advancement
        http://www.curedisease.com/Harms.html

        Smoking was thought non-carcinogenic because smoking-related cancer
        is difficult to reproduce in lab animals. Many continued to smoke and
        to die from cancer.[2]

        Benzene was not withdrawn from use as an industrial chemical despite
        clinical and epidemological evidence that exposure caused leukemia in
        humans, because manufacturer-supported tests failed to reproduce
        leukemia in mice.[1]

        Animal experiments on rats, hamsters, guinea pigs, mice, monkeys, and
        baboons revealed no link between glass fibers and cancer. Not until
        1991, due to human studies, did OSHA label it carcinogenic.[3][4][5]

        Though arsenic was a known human carcinogen for decades, scientists
        still found little evidence in animals to support the conclusion as
        late as 1977.[6] This was the accepted view until it was produced in
        lab animals.[7][8][9]

        Many continued to be exposed to asbestos and die because scientists
        could not reproduce the cancer in lab animals.

        Pacemakers and heart valves were delayed in development because of
        physiological differences between animals they were designed on and
        humans.

        Animal models of heart disease failed to show that a high
        cholesterol/high fat diet increases the risk of coronary artery
        disease. Instead of changing their eating habits to prevent the
        disease, people continued their lifestyles with a false sense of
        security.

        Patients received medications that were harmful and/or ineffective
        due to animal models of stroke.

        Animal studies predicted that beta-blockers would not lower blood
        pressure. This withheld their development.[10][11][12] Even animal
        experimenters admitted the failure of animal models of hypertension
        in this regard, but in the meantime, there were thousands more stroke
        victims.

        Surgeons thought they had perfected radial keratotomy, surgery
        performed to enable better vision without glasses, on rabbits, but
        the procedure blinded the first human patients. The rabbit cornea is
        able to regenerate on the underside, whereas the human cornea can
        only regenerate on the surface. Surgery is now performed only on the
        surface.

        Combined heart lung transplants were also "perfected" on animals, but
        the first 3 patients all died within 23 days.[13] Of 28 patients
        operated on between 1981 and 1985, 8 died peri-operatively, and 10
        developed obliterative bronchiolitis, a lung complication that the
        experimental dogs did not get. Of those 10, 4 died and 3 never
        breathed again without the aid of a respirator. Obliterative
        bronchiolitis turned out to be the most important risk of the
        operation.[14]

        Cyclosporin A inhibits organ rejection, and its development was
        watershed in the success of transplant operations. Had human evidence
        not overwhelmed unpromising evidence from animals, it would never
        have been released.[15]

        Animal experiments failed to predict the kidney toxicity of the
        general anesthetic methoxyflurane. Many people lost all kidney
        function.

        Animal experiments delayed the use of muscle relaxants during general
        anesthesia.

        Research on animals failed to reveal bacteria as a cause of ulcers
        and delayed treating ulcers with antibiotics.

        More than half of the 198 new medications released between 1976 and
        1985 were either withdrawn or relabeled secondary to severe
        unpredicted side effects.[16] These side effects included
        complications like lethal dysrhythmias, heart attacks, kidney
        failure, seizures, respiratory arrest, liver failure, and stroke,
        among others.

        Flosint, an arthritis medication, was tested on rats, monkeys and
        dogs; all tolerated the medication well. In humans, however it caused
        deaths.

        Zelmid, an antidepressant, was tested on rats and dogs without
        incident. It caused severe neurological problems in humans.

        Nomifensine, another antidepressant, was linked to kidney and liver
        failure, anemia, and death in humans. Animal testing had given it a
        clean, side effect-free bill of health.

        Amrinone, a medication used for heart failure, was tested on numerous
        animals and was released without trepidation. Humans developed
        thrombocytopenia, a lack of the type of blood cells that are needed
        for clotting.

        Fialuridine, an antiviral medication, caused liver damage in 7 out of
        15 people. 5 eventually died and 2 more needed liver transplants.[17]
        It worked well in woodchucks.[18][19]

        Clioquinol, an antidiarrheal, passed tests in rats, cats, dogs and
        rabbits. It was pulled off the shelves all over the world in 1982
        after it was found to cause blindness and paralysis in humans.

        Eraldin, a medication for heart disease, caused 23 deaths despite the
        fact that no untoward effects could be shown in animals. When
        introduced, scientists said it noted for the thoroughness of the
        toxicity studies on animals. It caused blindness and deaths in
        humans. Afterwards, scientists were unable to reproduce these results
        in animals.[20]

        Opren, an arthritis medication, killed 61 people. Over 3500 cases of
        severe reactions have been documented. Opren had been tested on
        monkeys and other animals without problems.

        Zomax, another arthritis drug, killed 14 people and caused many more
        to suffer.

        The dose of isoproterenol, a medication used to treat asthma, was
        worked out in animals. Unfortunately, it was much too toxic for
        humans. 3500 asthmatics died in Great Britain alone due to overdose.
        It is still difficult to reproduce these results in animals.[21][22]
        [23][24][25][26]

        Methysergide, a medication used to treat headaches, led to
        retroperitoneal fibrosis, or severe scarring of the heart, kidneys,
        and blood vessels in the abdomen.[27] Scientists have been unable to
        reproduce this in animals.[28]

        Suprofen, an arthritis drug, was withdrawn from the market when
        patients suffered kidney toxicity. Prior to its release researchers
        had this to say about the animal tests:[29][30] "...excellent safety
        profile. No ...cardiac, renal, or CNS [central nervous system]
        effects in any species."

        Surgam, another arthritis drug, was designed to have a stomach
        protection factor that would prevent stomach ulcers, a common side
        effect of many arthritis drugs. Although promising in lab animal
        tests, ulcers occurred in human trials.[31][32]

        Selacryn, a diuretic, was thoroughly tested on animals. It was
        withdrawn in 1979 after 24 people died from drug induced liver
        failure.[33][34]

        Perhexiline, a heart medication, was withdrawn when it produced liver
        failure that had not been predicted by animal studies. Even when they
        knew they were looking for a particular type of liver failure, they
        could not induce it in animals.[35]

        Domperidone, designed as a treatment for nausea and vomiting, made
        human hearts beat irregularly and had to be withdrawn. Scientists
        were unable to reproduce this in dogs even with 70 times the normal
        dose.[36][37]

        Mitoxantrone, a treatment for cancer produced heart failure in
        humans. It was extensively tested on dogs, which did not manifest
        this effect.[38][39]

        Carbenoxalone was supposed to prevent formation of gastric ulcers but
        caused people to retain water to the point of heart failure. After
        scientists knew what it did to humans they tested it on rats, mice,
        monkeys, rabbits, without reproducing this effect. [40][41]

        Clindamycin, an antibiotic, causes a bowel condition called
        pseudomenbraneous colitis. It was tested in rats and dogs every day
        for one year. They tolerate doses 10 times greater than humans.[42]
        [43][44]

        Animal experiments did not support the efficacy of valium-type drugs
        during development or after.[45][46]

        Pharmacia & Upjohn discontinued clinical tests of its Linomide
        (roquinimex) tablets for the treatment of multiple sclerosis after
        several patients suffered heart attacks. Of 1,200 patients, 8
        suffered heart attacks as a result of taking the medication. Animal
        experiments had not predicted this.

        Cylert (pemoline), a medication used to treat Attention Deficit
        Hyperactive Disorder, caused liver failure in 13 children. Eleven
        either died or needed a liver transplant.

        Eldepryl (selegiline), a medication used to treat Parkinson's
        disease, was found to induce very high blood pressure. This side
        effect has not been seen in animals, where it is used to treat senile
        dementia and endocrine disorders.

        The diet drug combination of fenfluramine and dexfenfluramine was
        linked to heart valve abnormalities and taken off the market although
        animal studies had never revealed heart abnormalities."[47]

        The diabetes medication troglitazone, better known as Rezulin, was
        tested on animals without significant problems, but caused liver
        damage in humans. The company admitted that at least one patient had
        died and another had to undergo a liver transplant as a result.[48]

        The plant digitalis has been used for centuries to treat heart
        disorders. However, clinical trials of the digitalis-derived drug
        were delayed because it caused high blood pressure in animals. Human
        evidence overrode. As a result, digoxin, an analogue of digitalis,
        has saved countless lives. Many more could it have survived had
        digitalis been released sooner.[49][50][51][52]

        FK 506, now called Tacrolimus, is an anti-rejection agent that was
        almost shelved before proceeding to clinical trials due to severe
        toxicity in animals.[53][54] Animal studies suggested that the
        combination of FK 506 with cyclosporin might prove more useful.[55]
        In fact, just the opposite proved true in humans.[56]

        Animal experiments suggested that corticosteroids would help septic
        shock, a severe bacterial infection of the blood.[57][58]
        Unfortunately, humans reacted differently. This treatment increased
        the death rate in cases of septic shock.[59]

        Despite the ineffectiveness of penicillin in his rabbits, Alexander
        Fleming used the antibiotic on a very sick patient since he had
        nothing else to try. Luckily, Fleming's initial tests were not on
        guinea pigs or hamsters, it kills them. Howard Florey, the Nobel
        Prize winner credited with co-discovering and manufacturing
        penicillin, stated: "How fortunate we didn't have these animal tests
        in the 1940s, for penicillin would probably never been granted a
        license, and possibly the whole field of antibiotics might never have
        been realized."

        Fluoride was withheld as a cavity preventative initially because it
        caused cancer in rats.[60][61][62]

        The notoriously dangerous drugs thalidomide and DES were tested in
        animals and released. Tens of thousands suffered and died as a
        result.

        Animal experiments misinformed researchers about how rapidly HIV
        replicates. Based on this false information, patients did not receive
        prompt therapies and their lives were shortened.

        Animal-based research delayed the development of the polio vaccine,
        according to Dr. Albert Sabin, its inventor. The first rabies and
        polio vaccines worked well on animals but crippled or killed the
        people who tried them.

        Researchers who work with animals have succumbed to illness and death
        due to exposure to diseases that though harmless to the animal host
        (such as Hepatitis B) but kill humans.

        Time, money, and resources devoted to these experiments could have
        gone to human-based research. Clinical studies, in vitro research,
        autopsies, post-marketing drug surveillance, computer modeling,
        epidemiology, and genetic research pose no hazard to humans and
        provide accurate results. Importantly, animal experiments have
        exhausted resources that could have been dedicated to educating the
        public about health hazards and health maintenance, therein
        diminishing the incidence of disease that require treatment.

        ANIMAL EXPERIMENTATION DOES NOT MAKE SENSE

        HUMAN-BASED SCIENCE PREVENTS DISEASE AND CREATES VALID THERAPIES

        REFERENCES:

        Sax, N. Cancer-causing Chemicals Van Nostrand 1981
        Lancet, June 25, 1977 p1348-9
        The Guardian, July 20, 1991
        Occupational Lung Disorders, Butterworth 1982
        Toxicology & Industrial Health, 1990, vol.6, p293-307
        J Nat Cancer Inst 1969, vol.42, 1045-52
        Br J Cancer, 1947, vol.1, p 192-251
        Advances in Modern Toxicology, vol.2, Wiley, 1977
        J Nat Cancer Inst, 1962, vol.5, p 459
        Fitzgerald, D. The development of new cardiovascular drugs in Recent
        Developments in Cardiovascular Drugs eds. Coltart and Jewitt,
        Churchill Livingstone 1981
        Perspectives in Biology & Medicine, 1980 Part 2, S9-S24
        Pharmacy International Feb. 1986; p33-37
        Lancet, i, p 130-2, 1983
        Lancet, 1, no. 8480 p 517-9, March 8, 1996
        Annals of Internal Medicine 1984, vol.101, 667-682
        GAO/PEMD-90-15 FDA Drug Review: Postapproval Risks 1976-1985
        NEJM 333;1099-1105, 1995
        J NIH Res, 1993, 5, 33-35
        Nature, 1993, July 22, p 275
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