To all interested scientists:
The Grand Challenges in Global Health initiative has selected 14 scientific
and technological challenges, the solution of which could lead to important
advances against diseases of the developing world. These challenges are
The Foundation for the National Institutes of Health now seeks innovative
solutions to these 14 critical research problems. Any scientist intrigued by
these challenges and interested in obtaining funding to solve them is
encouraged to apply. The Bill & Melinda Gates Foundation has awarded $200
million to the Foundation for NIH to administer this initiative with
guidance from a distinguished international Scientific Board.
Grants will be awarded for up to $20 million each, for a maximum five-year
period. Applications are invited from every part of the world, from single
or multiple institutions, both non-profit and for profit. Collaborative
approaches are encouraged. To apply for a research grant, investigators must
first submit a letter of intent (LOI). LOIs that propose the most promising
and innovative research approach will be given an invitation to submit a
formal grant proposal.
For detailed descriptions of the grand challenges, how they were selected,
and instructions on submitting letters of intent, please visit
www.grandchallegesgh.org. All letters of intent MUST comply with the
instructions on the Web site.
LOIs are due January 9, 2004.
Please distribute this e-mail to colleagues who may be interested in
obtaining funding to work on these important scientific problems.
Elke Jordan, Ph.D.
Grand Challenges in Global Health
Foundation for the National Institutes of Health
Goals and Grand Challenges
To improve childhood vaccines:
GC 1. Create effective single-dose vaccines that can be
used soon after birth;
GC 2 Prepare vaccines that do not require refrigeration;
GC 3 Develop needle-free delivery systems for vaccines.
To create new vaccines:
GC 4 Devise reliable tests in model systems to evaluate live
GC 5 Solve how to design antigens for effective, protective immunity;
GC 6 Learn which immunological responses provide protective immunity.
To control insects that transmit agents of disease:
GC 7 Develop a genetic strategy to deplete or incapacitate a disease-
transmitting insect population;
GC 8 Develop a chemical strategy to deplete or incapacitate a disease-
transmitting insect population.
To improve nutrition to promote health:
GC 9 Create a full range of optimal, bioavailable
nutrients in a single staple plant species.
To improve drug treatment of infectious diseases:
GC 10 Discover drugs and delivery systems that minimize the likelihood
of drug resistant micro-organisms.
To cure latent and chronic infections:
GC 11 Create therapies that can cure latent infections;
GC 12 Create immunological methods that can cure chronic
To measure disease and health status accurately and economically in
GC 13 Develop technologies that permit quantitative assessment of
population health status;
GC 14 Develop technologies that allow assessment of individuals for
multiple conditions or pathogens at point-of-care.