[Extrahepatic manifestations of chronic hepatitis C]
Vnepechenochnye proiavleniia khronicheskogo gepatita C.
AUTHORS: Ignatova TM; Aprosina ZG; Serov VV; Mukhin NA; Krel'PE;Semenkova
EN;PopovaIV; Tanashchuk EL
Ter Arkh 1998;70(11):9-16
PMID: 9949448 UI: 99134607
ABSTRACT: AIM: To study incidence, special features and mechanisms
underlying onset of extrahepatic lesions in HCV-infection.
MATERIALS AND METHODS: Extrahepatic symptoms of chronic hepatitis C and its
outcome--hepatic cirrhosis were studied in 157 patients. HCV-infection was
confirmed by ELISA II and polymerase chain reaction (detection in the serum
of anti-HCV and HCVRNA, respectively).
Morphological studies of the liver were made in 134 patients, of other
organs and tissues--in 20 patients. Immunological tests were made in 124
patients. Thyroid hormones, antibodies to thyroglobuline were
measured with radioimmunoassay in 74 patients.
RESULTS: Extrahepatic manifestations were found in 70(44.6%) patients
with chronic hepatitis C (more frequently in hepatic cirrhosis), for the
most part in women and in long-lasting disease. 54(43.5%) women had
cryoglobulinemia, 27 of them showed it clinically. Patients with
cryoglobulinemia and free of it exhibited varying frequency cutaneous
vasculitis, Raynaud's syndrome, affection of the muscles and joints, nodular
periartheritis, lesions of the lungs, myocarditis, autoimmune thyroiditis,
Sjogren's syndrome, lichen ruber planus, porphyria cutanea tarda, immune
cytopenia, autoimmune hemolytic anemia, hypoplastic anemia, monoclonal
immunoglobulinopathy, B-cell lymphoma. Of high frequency were activity of
rheumatic factor (66.9%), hypocomplementemia (31.8%), antinuclear antibodies
(9.8%) and other immunological disorders.
CONCLUSION: Some extrahepatic lesions in HCV-infection are detailed:
frequent mixed cryoglobulinemia and associated vasculitides of different
sites, malignan lymphoproliferative diseases, more frequent
than in HBV-infection involvement of the thyroid and salivary glands, some
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