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BIOLOGICAL 'FOUNTAIN OF YOUTH' FOUND IN NEW WORLD BAT CAVES
ScienceDaily
July 1, 2009

http://www.sciencedaily.com/releases/2009/06/090630101229.htm

Scientists from Texas are batty over a new discovery which could lead to the
single most important medical breakthrough in human history -- significantly
longer lifespans. The discovery, featured on the cover of the July 2009
print issue of The FASEB Journal, shows that proper protein folding over
time in long-lived bats explains why they live significantly longer than
other mammals of comparable size, such as mice.

"Ultimately we are trying to discover what underlying mechanisms allow for
some animal species to live a very long time with the hope that we might be
able to develop therapies that allow people to age more slowly," said Asish
Chaudhuri, Professor of Biochemistry, VA Medical Center, San Antonio, Texas
and the senior researcher involved in the work.

Asish and colleagues made their discovery by extracting proteins from the
livers of two long-lived bat species (Tadarida brasiliensis and Myotis
velifer) and young adult mice and exposed them to chemicals known to cause
protein misfolding. After examining the proteins, the scientists found that
the bat proteins exhibited less damage than those of the mice, indicating
that bats have a mechanism for maintaining proper structure under extreme
stress.

"Maybe Juan Ponce De León wasn't too far off the mark when he searched
Florida for the Fountain of Youth," said Gerald Weissmann, M.D.,
Editor-in-Chief of The FASEB Journal. "As it turns out, one of these bat
species lives out its long life in Florida. Since bats are rodents with
wings, this chemical clue as to why bats beat out mice in the aging game
should point scientists to the source of this elusive fountain."

............

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Published by David Sunfellow
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