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Rapamycin Increases Lifespan of “old” Mice   Message List  
Reply | Forward Message #8038 of 9148 |
RE: [ExtroBritannia] Rapamycin Increases Lifespan of “old” Mice


Would not encapsulation just require a gelatin capsule containing
gastro-resistant enteric-coated pellets with the rapamycin within these? This
would not add any significant cost to the medication as its a standard delivery
mechanism for a variety of current pharma.



mp







To: extrobritannia@yahoogroups.com
From: dirk.bruere@...
Date: Sat, 11 Jul 2009 14:27:24 +0100
Subject: Re: [ExtroBritannia] Rapamycin Increases Lifespan of “old” Mice







The problem being is that it is:
a) a powerful immuno-suppressant
b) is unstable in the stomach unless it goes through a rather complex
encapsulation procedure.

So at best it needs to be modified.
It also seems to operate on the same pathways as resveratrol, unless
I'm reading it wrong.
The best bet still seems to be either taking resveratrol *now* or
waiting for the Sirtis drugs to appear.
Still, another "proof of principle", and an extra decade of healthy
life at 60 is quite substantial

Dirk

2009/7/11 alex.02007 <alex.02007@...>:
>
>
> Rapamycin Increases Lifespan of "old" Mice
>
> This news was published in nature and it is actively being discussed in
> Immortality institute forum
>
> http://www.imminst.org/forum/Rapamycin-Increases-Mice-Longevity-t31286.html
>
> Rapamycin Increases Lifespan of "old" Mice
>
> This drug promises to give 23 years extra for humans.
>
> Alex.02007
>
>

--
Homepage: www.neopax.com








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Sat Jul 11, 2009 5:17 pm

mikepannell...
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Rapamycin Increases Lifespan of "old" Mice This news was published in nature and it is actively being discussed in Immortality institute forum ...
alex.02007
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Jul 11, 2009
9:39 am

The problem being is that it is: a) a powerful immuno-suppressant b) is unstable in the stomach unless it goes through a rather complex encapsulation...
Dirk Bruere
dirk.bruere
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Jul 11, 2009
1:28 pm

... My reading of this is that we need something that inhibits the TOR without suppressing the immune system or being borderline toxic. Neither Rapamycin nor...
ben
bbenzai
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Jul 11, 2009
5:12 pm

Would not encapsulation just require a gelatin capsule containing gastro-resistant enteric-coated pellets with the rapamycin within these? This would not add...
M P
mikepannell...
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Jul 11, 2009
5:17 pm

... True, but that's the least of its problems. I think it is important as a proof of principle. We now know for sure that a drug that extends lifespan is...
Dirk Bruere
dirk.bruere
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Jul 11, 2009
5:28 pm
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